Determine biomarkers for impulsivity in adolescents (Temple, Van den Berg).
As teen dating violence and disordered weight
control behaviors have been linked to impulsive tendencies, two of our
MTT projects study both behaviors in adolescents. Both projects collect
longitudinal data from adolescents from regional schools. Both Drs.
Temple and Van den Berg collect impulsivity data (Barratt Impulsiveness
Scale; BIS 11, and modified BIS) from human subjects, and will begin to
collect saliva samples to look for biomarkers.
Link epigenetic status of serotonin 2 receptor
(5-HT2R) genes to impulsivity and addiction phenotypes (Cunningham,
Moeller, Anastasio, Sowers)
Methylation of the 5-HT2AR gene promoter has been
implicated as a contributor to schizophrenia and mood disorders, and
previous studies revealed that levels of impulsivity positively
correlated with 5-HT2AR protein levels. This project looks at the
methylation of key residues of 5-HT2AR in cocaine-user human subjects
Develop pipeline to enhance medications development for impulsivity disorders (Cunningham, Gilbertson, Hommel, Zhou)
Current projects include the study and development
of small molecule compounds to treat impulsivity disorders including
cocaine addiction and relapse and obesity.
Establish best practices in translational research
The goal is to leverage the successes of our various
MTT projects to develop new collaborations and projects. MTT members
utilize monthly meetings and a web-based collaboration platform to
suggest and brainstorm potential collaborations, grant proposals, and