Translational Addiction Sciences Center

Welcome to the P50 TASC Team Website.  If you need access to P50 resource materials including meeting agendas, meeting notes, presentations, and publications please click on the link below.

P50 Resource Materials

TASC 2.0

KathrynACunninghamCore A: (Cunningham; Administrative Core) will centralize, coordinate and facilitate all activities of the Center to assure oversight of TASC organization, logistical and integrative processes and reduce barriers to success

Project 2 (Cunningham; Functional 5-HT2AR:5-HT2CR Imbalance in Impulsivity and Cue Reactivity) will employ rodent models to illuminate the 5-HT2AR:5-HT2CR functional signaling imbalances that drive impulsivity and cue reactivity and provide the experimental platform for rebalancing 5-HT2AR:5-HT2CR function

NoelleAnastasioCore B (Anastasio; Cellular Biology and Pharmacology Core) will engender synergy by coordinating genetic screening in humans (Project 1), cellular assays in vitro for new ligands (Project 1 and 3), signaling and localization ex vivo (Projects 2 and 3), and studies of receptor homo - and heteromers (Projects 2 and 3)

Dr. Moeller_Hi-DefProject 1 (Moeller; Serotonergic Regulation of Corticostriatal Connectivity in Cocaine Dependence) will utilize pharmaco-fMRI, dynamic causal modeling, and human laboratory tasks to reveal role of 5-HT2R genotypes driving connectivity within prefrontal-striatal-thalamic circuitry in impulsivity and cue reactivity

srgilbe2Project 3 (Gilbertson; Novel Chemical Probes to Study 5-HT2R Balance and Function) will design and synthesize bifunctional molecules with targeted actions at 5-HT2R to establish proof-of-concept efficacy against relapse in animal models and to study the unique biology of receptor homo- and heteromers

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