Gamma Irradiator Training Agenda

1. Radiation Safety Luz Cheng
  1.1 Review of basic radiation safety  
  1.2 Specifics of radiation safety with enclosed sources (GNL and Shope Lab irradiators  
  1.3 TDSHS Requirements for Security of Radioactive Materials of Concern  
2. Introduction to radiation biology Joan Nichols
  2.1 Use of irradiation to inactivate biological materials  
  2.2 Mechanism of ioizing raditation invactivation  
    2.2.1 Effect of target size on dosage required  
    2.2.2 Effect of target matrix on effect of radiation  
    2.2.3 Why kill curves are necessary  
3. Biological Safety in using gamma irradiation Dee Zimmermann
  3.1 Precautions to ensure biological safety in packaging  
  3.2 Transport and storage of material to irraditor  
  3.3 Ensuring inactivation (generation of kill curves) Tom Ksiazek
  3.4 SOP — kill curve  
  3.5 Example — machine output  
  3.6 Publication — Lassa / Ebola / Marburg examples of kill curves  
  3.7 Calculating expposure times or use of provided tables  
  3.8 Documenting inactivation  
4. Break  
5. Security Dee Zimmermann
  5.1 Select Agent Security  
    5.1.1 Precautions to insure security of removal from high containment labs  
    5.1.2 Precautions required in transfer of materials from Lab to irradiator or storage area  
    5.1.3 Documenting removal and inactivation of the material for security purposes  
6. Practical familiarization with the Devices Colette Pietzsch (Keng) and Terry Juelich
  6.1 Introduction to the mechanical aspects  
  6.2 Practical Demonstration of operation  
    6.2.1 Placing materials  
    6.2.2 Setting the Timing Mechanism on the Devices  
    6.2.3 Interruption of the exposure cycle for refreshing coolant  
    6.2.4 Termination of Run and Labeling of materials