Nephrology 

John Sealy

ResearchNephrology


The discovery of new understanding of pathological conditions and treatment is essential to advancement in human health. As such, it is the expectation that each fellow will design or participate in a scholarly activity during the training period. Clinical research is of several varieties, each important to this advancement.

Clinical research is divided into:

  1. Pathophysiological investigation-understanding the mechanisms of disease or therapies in cohorts of patients with the same condition.
  2. Outcomes or data mining research-using clinical data bases (local, regional, or national) to address observational associations that can lead to future mechanistic research.
  3. Non-parametric or behavioral research (including educational research).
  4. Translational research-collaborative investigation with basic scientists to extend basic science understanding to human disease states.
  5. Drug-company sponsored clinical trials.

The Division of Nephrology and Hypertension has been, or is, active in each of these arenas.    

Abstracts presented at national meetings over the past 3 years:

  1. Lal Y, Beach R, Recurrent Paraganlioma: Atypical presentation of a rare disorder. Accepted for Poster Presentation at the National Kidney Foundation Spring Clinical Meetings 2018; Austin, TX.
  2. Gamilla-Crudo A, Lal Y, Chaudhary V, Ramirez, R and Mujtaba, M. Preemptive Plasmapheresis for Prevention of Post-transplant FSGS Recurrence: UTMB Experience. Accepted for Poster Presentation at the National Kidney Foundation Spring Clinical Meetings 2018; Austin, TX.
  3. Chaudhary V, Lal Y, Chapman Y, Gamilla-Crudo A, Gugliuzza K, Hussain S and Mujtaba M. Do Organ Refusal Codes Really Matter? Accepted for Poster Presentation at the National Kidney Foundation Spring Clinical Meetings 2018; Austin, TX.
  4. Mujtaba M, Gamilla-Crudo A, Gugliuzza K, Aleter O, Shah S, Chapman Y, Reese J, Masood S, Taber T. Impact of Type 2 Surgical Injuries in Postmortem Donor Kidneys on the Post-Transplant Outcomes When Compared to Mate Non-Injured Kidney from the same donor. American Journal of Transplantation. 2017, Apr;17(S3): page663(411-485).
  5. Aleter O, Afrouzian M, Badalamenti J, Kassem H. Natural history of proliferative glomerulonephritis with monoclonal IgG deposits: a unique case with 3 renal biopsies obtained over 46 years of follow up. Poster presentation ASN Kidney Week, November 2017, New Orleans, LA.
  6. Noriega R, Kochar T, Kassem H, Ward A, Afrouzian M. Cryoglobulinemic glomerulonephritis in a patient with Sjogren Syndrome. Poster presentation ASN Kidney Week, November 2017, New Orleans, LA.
  7. Schreiber B, Espinoza F, Aleter O, Kassem H. Knowledge, attitude and practice of evaluation and management of mineral bone disease in chronic kidney disease amongst primary care physicians and nephrologists. Poster presentation ASN Kidney Week, November 2017, New Orleans, LA
  8. Mutnuri S, Kassem H, Afrouzian M. Lymphoma-associated monoclonal cryoglobulinemic GN in a patient with hepatitis C. Poster presentation ASN Kidney Week, November 2015, San Diego, CA
  9. Watts, III, B.A., T. George, E.R. Sherwood, and D.W. Good.  Monophosphoryl lipid A prevents sepsis-induced inhibition of HCO3- absorption in medullary thick ascending limb.  J. Am. Soc. Nephrol. 27: 367A, 2017.
  10. Shah S, Gamilla-Crudo A, Schreiber B, Espinoza F, Patankar R, Aleter O, Mujtaba M. Inter-correlations between Psychosocial Pre-transplant assessment as a determinant of Post-transplant kidney allograft function. Poster presented at the American Society of Nephrology Kidney Week 2017; New Orleans, LA, USA.
  11. Treatment of Post-Transplant De Novo HLA Donor Specific Antibodies in Kidney Transplant Recipient in the absence of rejection. Poster presented at 43rd Annual Meeting of the American Society for Histocompatibility and Immunogenetics, September 2017, San Francisco, CA, USA
  12. Schreiber B, Noriega R, Gamilla-Crudo A, Mujtaba M. Correlation of Pre-Kidney Transplant Psychosocial Factors with Post-Transplant Kidney Graft Survival. TH-PO979. JASN 2017: 28
  13. , Patankar R, Chaudhary V, Shah S, Mujtaba M. Comparison between delayed graft function and slow graft function in predicting outcomes amongst kidney transplant recipients. TH-PO920. JASN 2017: 28.
  14. Espinoza F, Patankar R, Noriega R, Chaudhary V, Mujtaba M. Waist to Hip Ratio as a predictor of increased length of stay post kidney transplant. TH-PO997, JASN 2017: 28
  15. Schreiber B, Mujtaba M. Cytomegalovirus infection and hemophagocytic lymphohistiocytosis in a renal transplant patient. PUB745, JASN 2017; 28.
  16. Schreiber B, Mujtaba M. Atypical case of calciphylaxis in a renal transplant recipient. PUB590. JASN 2017: 28.
  17. Patankar R, Gamilla-Crudo A, Gugliuzza K, Salim O, Ikram F, and Mujtaba M. Early Outcomes of Kidney Transplantation When Comparing Waist-to-Hip Ratio vs. Body Mass Index. Am J Transplant. 2017; 17 (suppl 3).

Manuscripts published in peer-reviewed journals over the past 3 years:

  1. Moinuddin, I., Yaqub, M. S., Taber, T., Mujtaba, M. and Sharfuddin, A.  Kidney Allograft Survival Outcomes in Combined Intestinal-Kidney Transplant: An Analysis of the UNOS/OPTN Database 2000-2014. Clin Transplant 2018 Jan 27. DOI 10.1111/ctr.13213.
  2. Watts, III, B.A., T. George, E.R. Sherwood, and D.W.Good.  Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway.  Am J Physiol Renal Physiol. 313:F103-F115, 2017. doi: 10.1152/ajprenal.00064.2017.
  3. Foshat, M, Ruff M, Fischer W, Beach R, Fowler M, Ju H, Aronson J, Afrouzian M. Bile cast nephropathy in cirrhotic patients: effects of chronic hyperbilirubinemia. Am J Clin Pathol (2017) 147 (5): 525-535.
  4. Beach R. E.  My Approach to Patient with Hematuria.  ePrimary Care, May 2017.
  5. Loupy A, Haas M, Solez K, Racusen L, Glotz D, Seron D, Nankivell BJ, Colvin RB, Afrouzian M, Akalin E, Alachkar N, Bagnasco S, Becker JU, Cornell L, Drachenberg C, Dragun D, de Kort H, Gibson IW, Kraus ES, Lefaucheur C, Legendre C, Liapis H, Muthukumar T, Nickeleit V, Orandi B, Park W, Rabant M, Randhawa P, Reed EF, Roufosse C, Seshan SV, Sis B, Singh HK, Schinstock C, Tambur A, Zeevi A, Mengel M. The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology. Am J Transplant. 2017 Jan;17(1):28-41.
  6. Liu YW, Mutnuri S, Siddiqui SB, Weikle GF, Oladipo O, Ganti N, Beach RE, and Afrouzian M..Levamisole-Adulterated Cocaine Nephrotoxicity: Ultrastructural Features. Am J Clin Pathol, May 2016;145:720-726.
  7. Deceased donor organ procurement injuries in the United States. Taber TE, Neidlinger NA, Mujtaba MA, Eidbo EE, Cauwels RL, Hannan EM, Miller JR, Paramesh AS. World J Transplant.2016 Jun 24;6(2):423-8. doi: 10.5500/wjt. v6.i2.423.
  8. Outcomes of Hepatitis C-Positive Kidney Transplant Recipients Compared with Hepatitis C-Negative Recipients in Today's Era of Immunosuppression: A UNOS Database Analysis with Long-Term Follow-Up. Khalil A, Mujtaba MA, Aljanabi OT, Ghabril MS, Taber TE, Yaqub MS, Sharfuddin A. Exp Clin Transplant. 2016 Jun 15. doi: 10.6002/ect.2015.0296.
  9. Re-transplants compared to Primary Kidney Transplants Recipients: A Mate Kidney Paired analysis of the OPTN/UNOS database. Khalil AK, Mujtaba MA, Yaqub MS, Mishler DP, Taber TE, Sharfuddin AA. Clin Transplant. 2016 Feb 23. doi: 10.1111/ctr.12722.
  10. Effect of Treatment with Tabalumab, a B Cell-Activating Factor Inhibitor, on Highly Sensitized Patients with End-Stage Renal Disease Awaiting Transplantation. Mujtaba MA, Komocsar WJ, Nantz E, Samaniego MD, Henson SL, Hague JA, Lobashevsky AL, Higgins NG, Czader M, Book BK, Anderson MD, Pescovitz MD, Taber TE.Am J Transplant. 2016 Jan 18. doi: 10.1111/ajt.13557.
  11. Watts, III, B.A., T. George, A. Badalamenti, and D.W. Good.  High mobility group box 1 inhibits HCO3- absorption in medullary thick ascending limb through RAGE-Rho-ROCK-mediated inhibition of basolateral Na+/H+ exchange.  Am. J. Physiol. Renal Physiol. 311: F600-F613, 2016.
  12. Good, D.W., T. George, and B.A. Watts, III.  High mobility group box 1 inhibits HCO3- absorption in medullary thick ascending limb through a basolateral receptor for advanced glycation end products pathway.  Am. J. Physiol. Renal Physiol. 309: F720-F730, 2015.
  13. Beach R. E. My Approach to Chronic Kidney Disease. ePrimary Care, November 2015.
  14. Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease. Jhawar S, Singh P, Torres D, Ramirez-Valle F, Kassem H, Banerjee T, Dolgalev I, Heguy A, Zavadil J, Lowenstein J. PLoS One. 2015 Mar 26;10(3).
  15. Trends and Outcomes in Right versus Left Living Donor Nephrectomy: An Analysis of the OPTN/UNOS Database of Donor and Recipient Outcomes. Should we be doing more Right Sided Nephrectomies? Khalil A, Mujtaba MA, Taber TE, Yaqub MS, Goggins W, Powelson J, Sundaram C, Sharfuddin AA. Clin Transplant. 2015 Nov 21. doi: 10.1111/ctr.12668.
  16. Re-exposure to beta cell autoantigens in pancreatic allograft recipients with preexisting beta cell autoantibodies. Mujtaba MA, Fridell J, Book B, Faiz S, Sharfuddin A, Wiebke E, Rigby M, Taber T. Clin Transplant. 2015 Nov;29(11):991-6. doi: 10.1111/ctr.12619.
  17. Early Fatal Cutaneous Lower Extremity Angiosarcoma Associated with Deep Venous Thrombosis in a Renal Transplant Recipient. Sher SJ, Mujtaba MA, Yaqub MS, Taber TE, Mishler DP, Sharfuddin AA. Exp Clin Transplant. 2015 Jul 2. doi:  0.6002/ect.2014.0289.
  18. Long Term Outcomes of Transplant Recipients Referred for Angiography for Suspected Transplant Renal Artery Stenosis. Ali A, Mishler D, Taber T, Agarwal D, Yaqub M, Mujtaba M, Goggins W, Sharfuddin A. Clin Transplant. 2015 Jun 5. doi: 0.1111/ctr.12574.
  19. Pre-transplant angiotensin receptor II type 1 antibodies and risk of post-transplant focal segmental glomerulosclerosis recurrence. Mujtaba MA, Sharfuddin AA, Book BL, Goggins WC, Khalil AA, Mishler DP, Fridell JA, Yaqub MS, Taber TE. Clin Transplant. 2015 May 12. doi: 10.1111/ctr.12562.
  20. Impact of duration of diabetes on outcome following pancreas transplantation. Ekser B, Mangus RS, Powelson JA, Goble ML, Mujtaba MA, Taber TE, Fridell JA. Int J Surg. 2015 Apr 11; 18:21-27. doi: 10.1016/j.ijsu.2015.04.031.
  21. Fridell JA, Mangus RS, Chen JM, Goble ML, Mujtaba MA, Taber TE, Powelson JA. Late pancreas retransplantation. Clin Transplant. 2015 Jan; 29(1):1-8. doi: 10.1111/ctr.12468.