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ResearchNephrology


The discovery of new understanding of pathological conditions and treatment is essential to advancement in human health. As such, it is the expectation that each fellow will design or participate in a scholarly activity during the training period. Clinical research is of several varieties, each important to this advancement.

Clinical research is divided into:

  1. Pathophysiological investigation-understanding the mechanisms of disease or therapies in cohorts of patients with the same condition.
  2. Outcomes or data mining research-using clinical data bases (local, regional, or national) to address observational associations that can lead to future mechanistic research.
  3. Non-parametric or behavioral research (including educational research).
  4. Translational research-collaborative investigation with basic scientists to extend basic science understanding to human disease states.
  5. Drug-company sponsored clinical trials.

The Division of Nephrology and Hypertension has been, or is, active in each of these arenas.    

Abstracts presented at national meetings over the past 3 years:

  1. Gamilla-Crudo, A, Hussain, S, Rizvi, A, Ramirez, R, Kueht, M, Stevenson-Lerner, H, Fair, J, Mujtaba, MA. Three Year Post Co-Stimulation Blocking Agent (Belatacept) Switch Outcomes of Kidney Transplant Patients Diagnosed with Post-Transplant Thrombotic Microangiopathy. Peer-reviewed accepted abstract for oral and poster presentation at American Transplant Congress (ATC) meeting, May 2020, Philadelphia, PA.
  2. Mujtaba, MA, Kueht, M, Hussain, SA, Rizvi, A, Shah, S, Kulkarni, R, Merwat, SN, Gamilla-Crudo, A. Outcomes of Kidney Transplant Patients Evaluated, Listed, and Managed Using A Distant Transplant Outreach Care Model (DTrOM). Peer-reviewed accepted abstract and poster presentation at American Transplant Congress (ATC) virtual meeting, May 2020, Philadelphia, PA.
  3. Rizvi, A, Al-Hosainat, N, Elharrif, K, Badalamenti, J, Kassem, H. Triad of Legionella Pneumonia, Rhabdomyolysis, and Acute Kidney Injury – A Case Report. Peer-reviewed accepted abstract and poster presentation at National Kidney Foundation (NKF) virtual meeting, March 2020, New Orleans, LA.
  4. Hussein, H, Shancy, J, Kochar, T. A case of minimal change disease associated with acute tubular necrosis and interstitial nephritis. Peer-reviewed accepted abstract and poster presentation at National Kidney Foundation (NKF) virtual meeting, March 2020, New Orleans, LA.
  5. Rizvi, A, Al-Hosainat, N, Hussain, SA, Keuht, M, Stevenson, H, Gamilla-Crudo, A, Mujtaba, MA. Non-invasive Post-kidney Transplant Monitoring Tools versus Invasive Molecular Microscope Diagnostic System (MMDx) and Conventional Biopsy for Antibody-mediated Rejection – Case Reports. Peer-reviewed accepted abstract and poster presentation at National Kidney Foundation (NKF) virtual meeting, March 2020, New Orleans, LA.
  6. Rizvi, A, Gamilla-Crudo, A, Hussain, SA, Al-Hosainat, N, Keuht, M, Stevenson, H, Mujtaba, MA. Non-invasive Post-kidney Transplant Monitoring Tools versus Invasive C4d Negative Conventional Biopsy for Antibody-mediated Rejection – Case Reports. Peer-reviewed accepted abstract and poster presentation at National Kidney Foundation (NKF) virtual meeting, March 2020, New Orleans, LA.
  7. Mitchell, A, Kassem, H, Aleter, O, Badalamenti, J, Hayes, KM. Patient Activation and ESRD: Impact of Patient Activation on Dialysis Modality Choice. Peer-reviewed accepted abstract and poster presentation at National Kidney Foundation virtual meeting, March 2020, New Orleans, LA.
  8. Abifaraj, F, Aleter, O, Hsu, E, Badalamenti, J, Kassem, H.  Effect of switching dialysis modalities on metabolic and nutritional parameters: Analysis from USRDS. Peer-reviewed accepted abstract and poster presentation at the American Society of Nephrology Kidney Week November 2019, Washington, DC.
  9. Peer-reviewed accepted abstract and poster presentation at the American Society of Nephrology Kidney Week November 2019, Washington, DC.
  10. Alhosainat, N, Gamilla-Crudo, A, Hussain, SA, Mujtaba, MA, Antibody- Mediated Rejection Detection: A Noninvasive perspective. Peer-reviewed accepted abstract and poster presentation at the American Society of Nephrology Kidney Week November 2019, Washington, DC.
  11. Elharrif, K, Gamilla-Crudo, A, Hussain, SA, Ramirez, RL, Abifaraj, F, Mujtaba, MA. Outcomes of Kidney Allograft Function in Patient with Thrombotic Microangiopathy Switched to Co-Stimulation Blocking Agent (Belatacept). Peer-reviewed accepted abstract and poster presentation at the American Society of Nephrology Kidney Week November 2019, Washington, DC.
  12. Watts, BA III, Tamayo, E, Sherwood, ER, Good, DW. Induction of the intracellular immunomodulator Toll-interacting protein mediates monophosphoryl lipid A-induced protection against lipopolysaccharide in medullary thick ascending limb. J Am Soc Nephrol. 2019;30:841.
  13. Eltaweel, O, Elharrif, K, Kassem, H, Diffuse Alveolar Hemorrhage Treated with Plasma Exchange in a Systemic Lupus Erythematosus Patient. Poster presentation at American College of Physicians meeting June 2019, Houston, TX.
  14. Gamilla-Crudo, A, Abifaraj, F, Hussain, SA, Mujtaba, MA. A Rare Presentation of Calciphylaxis in Kidney Transplant. Abstract Poster presented at the National Kidney Foundation Spring Clinical meetings 2019, Boston, MA
  15. Omitogun, T, Jacob, S, Beach, R, Elharrif, K.  A Case of Thin Basement Membrane Nephropathy with Focal Segmental Glomerulosclerosis and Heavy Proteinuria. Poster presentation at NKF meeting 2019, Washington, DC.
  16. Elharrif, K, Lal, Y, Amin, A, Alhosainat, N, Gamilla-Crudo, A, Hussain, SA, Gugliuzza, K, Mujtaba, MA. Transplant Kidney Outcomes in Patients with Thrombotic Microangiopathy, Switched to Co-Stimulation Blocking Agent (Belatacept). Poster presentation at NKF meeting 2019, Washington, DC.
  17. Alhosainat, N, Lal, Y, Amin, A, Elharrif, K, Gamilla-Crudo, A, Hussain, SA, Gugliuzza , K, Mujtaba, MA. Deceased Donor Kidney Transplant from A2/A2B to B Recipients; Navigating through IgM challenge. Poster presentation at NKF meeting 2019, Washington, DC.
  18. Mujtaba, MA, Hussain, SA, Amin, A, Al-Hosainat, N, Lal, Y, Elharrif, K, Gamilla-Crudo, A. Impact of Kidney Disease in Liver Transplant Rejection. Poster presentation at NKF meeting 2019, Washington, DC.
  19. Lal, Y, Williams, K, Afrouzian, M, Amin, A, Kassem, H. Membranous glomerulopathy with monoclonal deposits, a case report with extended period of follow up. Poster presentation at NKF meeting 2019, Washington, DC.
  20. Schreiber, B, Aleter, O, Chaudhary, V, Fischer, W, Lal, Y, Kassem, H. Is it Time to Switch? Comparing transplant outcomes among dialysis modalities: Analysis from the United States Renal Data System (USRDS). Poster presentation at the American Society of Nephrology Kidney Week October 2018, San Diego, CA.
  21. Abifaraj F, Lal, Y, Fischer, W, Badalamenti, J, Kassem, H. Switching Dialysis Modalities for a Better Outcome: Analysis from the United States Renal Data System (USRDS). Poster presentation at the American Society of Nephrology Kidney Week October 2018, San Diego, CA.
  22. Lal, Y, Kassem, H, Ukudeyeva, A, Charles, D, Etienne, S, Fischer, W, Afrouzian, M. Collapsing Glomerulopathy in Hepatitis C Virus Positive Patients: A Retrospective Autopsy Study of 95 Cases. Poster presentation at the American Society of Nephrology Kidney Week October 2018, San Diego, CA.
  23. Espinoza, F, Afrouzian, M, Omitogun, T, Kassem, H. Hepatitis B and C dual infection and collapsing glomerulopathy: Report of a rare association. Poster presentation at the American Society of Nephrology Kidney Week October 2018, San Diego, CA.
  24. Lal, Y, Beach, R, Recurrent Paraganlioma: Atypical presentation of a rare disorder. Poster Presentation at the National Kidney Foundation Spring Clinical Meetings 2018, Austin, TX.
  25. Gamilla-Crudo, A, Lal, Y, Chaudhary, V, Ramirez, R and Mujtaba, MA. Preemptive Plasmapheresis for Prevention of Post-transplant FSGS Recurrence: UTMB Experience. Poster Presentation at the National Kidney Foundation Spring Clinical Meetings 2018, Austin, TX.
  26. Chaudhary, V, Lal, Y, Chapman, Y, Gamilla-Crudo, A, Gugliuzza, K, Hussain, S and Mujtaba, MA. Do Organ Refusal Codes Really Matter? Poster Presentation at the National Kidney Foundation Spring Clinical Meetings 2018, Austin, TX.
  27. Mujtaba, MA, Gamilla-Crudo, A, Gugliuzza, K, Aleter, O, Shah, S, Chapman, Y, Reese, J, Masood, S, Taber T. Impact of Type 2 Surgical Injuries in Postmortem Donor Kidneys on the Post-Transplant Outcomes When Compared to Mate Non-Injured Kidney from the same donor. American Journal of Transplantation. 2017, Apr;17(S3): page663(411-485).
  28. Aleter, O, Afrouzian, M, Badalamenti, J, Kassem, H. Natural history of proliferative glomerulonephritis with monoclonal IgG deposits: a unique case with three renal biopsies obtained over 46 years of follow up. Poster presentation ASN Kidney Week, November 2017, New Orleans, LA.
  29. Noriega, R, Kochar, T, Kassem, H, Ward, A, Afrouzian, M. Cryoglobulinemic glomerulonephritis in a patient with Sjogren Syndrome. Poster presentation ASN Kidney Week, November 2017, New Orleans, LA.
  30. Schreiber, B, Espinoza, F, Aleter, O, Kassem, H. Knowledge, attitude and practice of evaluation and management of mineral bone disease in chronic kidney disease amongst primary care physicians and nephrologists. Poster presentation ASN Kidney Week, November 2017, New Orleans, LA
  31. Mutnuri, S, Kassem, H, Afrouzian, M. Lymphoma-associated monoclonal cryoglobulinemic GN in a patient with hepatitis C. Poster presentation ASN Kidney Week, November 2015, San Diego, CA
  32. Watts, III, B.A., George, T, Sherwood, E.R. and Good, D.W.  Monophosphoryl lipid A prevents sepsis-induced inhibition of HCO3- absorption in medullary thick ascending limb.  J. Am. Soc. Nephrol. 27: 367A, 2017.
  33. Shah, S, Gamilla-Crudo, A, Schreiber, B, Espinoza, F, Patankar, R, Aleter, O, Mujtaba, M. Inter-correlations between Psychosocial Pre-transplant assessment as a determinant of Post-transplant kidney allograft function. Poster presented at the American Society of Nephrology Kidney Week 2017, New Orleans, LA, USA.

Manuscripts recently published in peer-reviewed journals:

  1. Kassem, H, Chatila, K, Curr Opin Nephrol Hypertens. Mineralocorticoid receptor antagonists in heart failure patients with chronic kidney disease: why, when, and how? 2020 March;29(2):258-263.
  2. Nassar, GM, Beathard, G, Nguyen, DT, Graviss, EA. The effect of angioplasty of single arteriovenous fistula-associated stenosis on arteriovenous fistula blood flow rate. J Vasc Access 2020:1129729819901223.
  3. Beathard, GA, Litchfield, T, Jennings, WC. Two-year cumulative patency of endovascular arteriovenous fistula. J Vasc Access 2020; 21:350.
  4. Nassar, GM, Beathard, G. Exploring correlations between anatomic characteristics of dialysis arteriovenous fistula stenosis and arteriovenous fistula blood flow rate (Qa). J Vasc Access 2020; 21:60.
  5. Rizvi, A, Seyedsaadat, SM, Alzuabi, M, Murad, MH, Kadiirvel, R, Brinjikji, W, and Kallmes, DF. Long-Term Rupture Risk in Patients with Unruptured Intracranial Aneurysms Treated with Endovascular Therapy: A Systematic Review and Meta-Analysis. Am J Neuroradiol. 2020.
  6. Rizvi, A, Marcus, RP, Guo, Y, Carter, R, Mark, IT, Foley, TA, Weber, NM, Sheedy, EN, Leng, S and Williamson, EE. Dynamic computed tomographic assessment of the mitral annulus in patients with and without mitral prolapse. J Cardiovasc Comput Tomogr. 2020.
  7. Seyedsaadat, SM, Yolcu, YU, Neuhaus, A, Rizvi, A, Alzuabi, M, Murad, MH, Brinjikji, W, Bydon, M and Kallmes, DF. Submaximal angioplasty in the treatment of patients with symptomatic ICAD: a systematic review and meta-analysis. J Neurointerv Surg. 2020; 12:380-385.
  8. Van Rosendael, AR, Narula, J, Lin, FY, van den Hoogen, IJ, Gianni, U, Al Hussein, Alawamlh, O, Dunham, PC, Pena, JM, Lee, SE, Andreini, D, Cademartiri, F, Chinnaiyan, K, Chow, BJW, Conte, E, Cury, RC, Feuchtner, G, Hadamitzky, M, Kim, YJ, Leipsic, J, Maffei, E, Marques, H, de Araujo Goncalves, P, Plank ,F, Ponton,e G, Raff, GL, Villines, TC, Weirich, HG, Al'Aref, SJ, Baskaran, L, Cho, I, Danad, I, Han, D, Heo, R, Lee, JH, Rivzi, A, Stuijfzand, WJ, Gransa,r H, Lu, Y, Sung, JM, Park, HB, Samady, H, Stone, PH, Virmani, R, Budoff, MJ, Berman, DS, Chang, HJ, Bax, JJ, Min, JK, Shaw, LJ. Association of High-Density Calcified 1K Plaque With Risk of Acute Coronary Syndrome. JAMA Cardiol. 2020.
  9. Mutnuri, S, Kassem, H, Badalamenti, J, Qian, YW, Marquez, C, Afrouzian, M. Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship With Hepatitis C Virus Infection: A Case Report. Case Rep Nephrol. 2019 Aug 18, 2019:7940291. doi: 10.1155/2019/7940291.
  10. Watts, BA III, Tamayo, E, Sherwood, ER, Good, DW. Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through induction of Tollip and negative regulation of IRAK-1. Am J Physiol Renal Physiol. 2019; 317(3):F705‐F719. doi:10.1152/ajprenal.00170.2019
  11. Beathard, GA, Litchfield, T, Jennings, WC. Two-year cumulative patency of endovascular arteriovenous fistula [published online ahead of print, 2019 Sep 28]. J Vasc Access. 2019
  12. Mallios, A, Beathard, GA, Jennings, WC. Early cannulation of percutaneously created arteriovenous hemodialysis fistulae [published online ahead of print, 2019 Dec 19]. J Vasc Access. 2019
  13. Beathard, GA, Jennings, WC, Wasse, H, et al. ASDIN white paper: Assessment and management of hemodialysis access-induced distal ischemia by interventional nephrologists. J Vasc Access 2019:1129729819894774.
  14. Rizvi, A, Seyedsaadat, SM, Alzuabi, M, Dugani, SB, Murad, MH, Huston, J 3rd, Saba, L and Brinjikji, W. Correlation of MRI-detected vulnerable carotid plaques with clinical presentation: a systematic review and meta-analysis. J Neurosurg Sci. 2019.
  15. Lee, JH, Rizvi, A, Hartaigh, BO, Han, D, Park, MW, Roudsari, HM, Stuijfzand, WJ, Gransar, H, Lu, Y, Callister, TQ, Berman, DS, DeLago, A, Hadamitzky, M, Hausleiter, J, Al-Mallah, MH, Budoff, MJ, Kaufmann, PA, Raff, GL, Chinnaiyan, K, Cademartiri, F, Maffei, E, Villines, TC, Kim, YJ, Leipsic, J, Feuchtner, G, Pontone, G, Andreini, D, Marques, H, de Araujo, Goncalves, P, Rubinshtein, R, Achenbach, S, Shaw, LJ, Chow, BJW, Cury, RC, Bax, JJ, Chang, HJ, Jones, EC, Lin, FY, Min, JK and Pena JM. The Predictive Value of Coronary Artery Calcium Scoring for Major Adverse Cardiac Events According to Renal Function (from the Coronary Computed Tomography Angiography Evaluation for Clinical Outcomes: An International Multicenter [CONFIRM] Registry). Am J Cardiol. 2019;123:1435-1442.
  16. Moinuddin, I, Yaqub, M S, Taber, T, Mujtaba, MA. and Sharfuddin, A.  Kidney Allograft Survival Outcomes in Combined Intestinal-Kidney Transplant: An Analysis of the UNOS/OPTN Database 2000-2014. Clin Transplant 2018 Jan 27. DOI 10.1111/ctr.13213.
  17. Watts, III, B.A., George, T, Sherwood, E.R., and Good, D.W.  Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway.  Am J Physiol Renal Physiol. 313:F103-F115, 2017. doi: 10.1152/ajprenal.00064.2017.
  18. Foshat, M, Ruff, M, Fischer, W, Beach, R, Fowler, M, Ju, H, Aronson, J, Afrouzian, M. Bile cast nephropathy in cirrhotic patients: effects of chronic hyperbilirubinemia. Am J Clin Pathol (2017) 147 (5): 525-535.
  19. Beach, R. E.  My Approach to Patient with Hematuria.  ePrimary Care, May 2017.
  20. Loupy, A, Haas, M, Solez, K, Racusen, L, Glotz, D, Seron, D, Nankivell, BJ, Colvin, RB, Afrouzian, M, Akalin, E, Alachka,r N, Bagnasco, S, Becker, JU, Cornell, L, Drachenberg, C, Dragun, D, de Kort, H, Gibson, IW, Kraus, ES, Lefaucheur, C, Legendre, C, Liapis, H, Muthukumar, T, Nickeleit, V, Orandi, B, Park, W, Rabant, M, Randhawa, P, Reed, EF, Roufosse, C, Seshan, SV, Sis, B, Singh, HK, Schinstock, C, Tambur, A, Zeevi, A, Mengel, M. The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology. Am J Transplant. 2017 Jan;17(1):28-41. ,
  21. Liu, YW, Mutnuri, S, Siddiqui, SB, Weikle, GF, Oladipo O, Ganti, N, Beach, RE, and Afrouzian M. Levamisole-Adulterated Cocaine Nephrotoxicity: Ultrastructural Features. Am J Clin Pathol, May 2016, 145:720-726.
  22. Taber, TE, Neidlinger, NA, Mujtaba, MA, Eidbo, EE, Cauwels, RL, Hannan, EM, Miller, JR, Paramesh AS. Deceased donor organ procurement injuries in the United States. World J Transplant. 2016 Jun 24; 6(2):423-8. doi: 10.5500/wjt. v6.i2.423.
  23. Khalil, A, Mujtaba, MA, Aljanabi, OT, Ghabril, MS, Taber, TE, Yaqub, MS, Sharfuddin, A. Outcomes of Hepatitis C-Positive Kidney Transplant Recipients Compared with Hepatitis C-Negative Recipients in Today's Era of Immunosuppression: A UNOS Database Analysis with Long-Term Follow-Up. Exp Clin Transplant. 2016 Jun 15. doi: 10.6002/ect.2015.0296.
  24. Khalil AK, Mujtaba MA, Yaqub MS, Mishler DP, Taber TE, Sharfuddin AA. Re-transplants compared to Primary Kidney Transplants Recipients: A Mate Kidney Paired analysis of the OPTN/UNOS database. Clin Transplant. 2016 Feb 23. doi: 10.1111/ctr.12722.
  25. Mujtaba, MA, Komocsar, WJ, Nantz, E, Samaniego, MD, Henson, SL, Hague, JA, Lobashevsky, AL, Higgins, NG, Czader, M, Book, BK, Anderson, MD, Pescovitz, MD, Taber, TE. Effect of Treatment with Tabalumab, a B Cell-Activating Factor Inhibitor, on Highly Sensitized Patients with End-Stage Renal Disease Awaiting Transplantation. Am J Transplant. 2016 Jan 18. doi: 10.1111/ajt.13557.
  26. Watts, III, B.A., T, George, A, Badalamenti, J, Good, DW.  High mobility group box 1 inhibits HCO3- absorption in medullary thick ascending limb through RAGE-Rho-ROCK-mediated inhibition of basolateral Na+/H+ exchange.  Am. J. Physiol. Renal Physiol. 311: F600-F613, 2016.
  27. Good, DW, George, T, and Watts, III BA. High mobility group box 1 inhibits HCO3- absorption in medullary thick ascending limb through a basolateral receptor for advanced glycation end products pathway.  Am. J. Physiol. Renal Physiol. 309: F720-F730, 2015.
  28. Beach, R. E. My Approach to Chronic Kidney Disease. ePrimary Care, November 2015.
  29. Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal diseasePLoS One. 2015 Mar 26;10(3).
  30. Khalil, A, Mujtaba, MA, Taber, TE, Yaqub, MS, Goggins, W, Powelson, J, Sundaram, C, Sharfuddin AA. Trends and Outcomes in Right versus Left Living Donor Nephrectomy: An Analysis of the OPTN/UNOS Database of Donor and Recipient Outcomes. Should we be doing more Right Sided Nephrectomies? Clin Transplant. 2015 Nov 21. doi: 10.1111/ctr.12668.
  31. Mujtaba, MA, Fridell, J, Book, B, Faiz, S, Sharfuddin, A, Wiebke, E, Rigby, M, Taber, T.  Re-exposure to beta cell autoantigens in pancreatic allograft recipients with preexisting beta cell autoantibodies. Clin Transplant. 2015 Nov, 29(11):991-6. doi: 10.1111/ctr.12619.
  32. Sher, SJ, Mujtaba, MA, Yaqub, MS, Taber, TE, Mishler, DP, Sharfuddin, AA. Early Fatal Cutaneous Lower Extremity Angiosarcoma Associated with Deep Venous Thrombosis in a Renal Transplant Recipient. Exp Clin Transplant. 2015 Jul 2. doi:  0.6002/ect.2014.0289.
  33. Ali, A, Mishler, D, Taber, T, Agarwal, D, Yaqub, M, Mujtaba, M, Goggins, W, Sharfuddin, A. Long Term Outcomes of Transplant Recipients Referred for Angiography for Suspected Transplant Renal Artery Stenosis. Clin Transplant. 2015 Jun 5. doi: 0.1111/ctr.12574.
  34. Mujtaba, MA, Sharfuddin, AA, Book, BL, Goggins, WC, Khalil, AA, Mishler, DP, Fridell, JA, Yaqub, MS, Taber, TE. Pre-transplant angiotensin receptor II type 1 antibodies and risk of post-transplant focal segmental glomerulosclerosis recurrence. Clin Transplant. 2015 May 12. doi: 10.1111/ctr.12562.
  35. Ekser, B, Mangus, RS, Powelson, JA, Goble, ML, Mujtaba, MA, Taber, TE, Fridell, JA. Int J Surg. Impact of duration of diabetes on outcome following pancreas transplantation. 2015 Apr 11; 18:21-27. doi: 10.1016/j.ijsu.2015.04.031.
  36. Fridell, JA, Mangus, RS, Chen, JM, Goble, ML, Mujtaba, MA, Taber, TE, Powelson, JA. Late pancreas retransplantation. Clin Transplant. 2015 Jan 29(1):1-8. doi: 10.1111/ctr.12468.