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doctors examining something

The discovery of new understanding of pathological conditions and treatment is essential to advancement in human health. As such, it is the expectation that each fellow will design or participate in a scholarly activity during the training period. Clinical research is of several varieties, each important to this advancement.

Clinical research is divided into:

  1. Pathophysiological investigation-understanding the mechanisms of disease or therapies in cohorts of patients with the same condition.
  2. Outcomes or data mining research-using clinical data bases (local, regional, or national) to address observational associations that can lead to future mechanistic research.
  3. Non-parametric or behavioral research (including educational research).
  4. Translational research-collaborative investigation with basic scientists to extend basic science understanding to human disease states.
  5. Drug-company sponsored clinical trials.

The Division of Nephrology and Hypertension has been, or is, active in each of these arenas.

  1. Determination of the renin to BNP ratio as a marker of volume expansion from CHF in patients with ESRD-S. Bhayana and R. Beach.
  2. Regulation of renin secretion by AP-1 transactivating factor in humans-R. Beach
  3. Outcomes on cardiovascular disease with treatment of hyperuricemia with xanthineoxidase inhibitors-C. Takkar and R. Beach
  4. Regulation of calcitropic hormones in African-Americans with hypertension-R. Beach. Poster presentation at NKF meeting.
  1. Case report on renal recovery in a young patient with multiple myeloma-H. Salameh, A. Ahmad, T. Kochar. Poster presentation at NKF meeting.
  2. Utilization of the HOMA test with simultaneous kidney and pancreas transplantation-G. Osuchukwu, T. Kochar, H. Adrogue. Oral presentation at AST meeting.
  3. Use of urinary pO2 to determine risk of AKI in critically ill patients-N. Mastouri and R. Beach
  4. Incidence and relationship to urine flow rates of acquired cystic disease of the kidneys in patients on peritoneal dialysis, home hemodialysis, and in-center hemodialysis-C. Takkar, T. Kochar, and R. Beach.
  5. Comparison of effectiveness of natriuresis with combination diuretics in refractory ascites in cirrhosis-S. Mittal and R. Beach.
  6. A Multi-Center, Randomized, Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type I with Lucassin (Terlipressin)- K. Crudo and H. Duchini.
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