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Tapas Hazra, PhD
Professor, Division of Pulmonary Critical Care & Sleep Medicine

Tapas Hazra, PhD

Tapas Hazra, PhD
Professor, Department of Internal Medicine and
Scientist, Sealy Center for Molecular Medicine
Division of Pulmonary Critical Care & Sleep Medicine

University of Texas Medical Branch
301 University Blvd.
Galveston, TX 77555-1079
Phone: 409.772.6308
Fax: 409.747.8608


Degree/Training Completed Year Name & Location
B.Sc Chemistry 1982 Calcutta University, India
M.Sc Biochemistry 1985 Calcutta University, India
Ph.D Biochemistry 1992 Jadavpur University, India

Research Interests

  • Oxidative damage repair in mammalian genomes
  • Enzyme kinetics, biochemical and cellular characterization of protein-protein and protein-DNA interactions
  • Post-translational modification of DNA repair proteins, SNP analysis, mutation analysis, transcription-coupled repair of oxidized bases, DNA repair and inflammation: linkage to disease susceptibility.

Selected Publications

  1. Hazra, TK; Izumi, T.; Boldogh, I.; Imhoff, B.; Kow, Y. W.; Jaruga, P., Dizdaroglu, M. and Mitra S.  Identification and characterization of a human DNA glycosylase for repair in modified bases in oxidatively damaged DNA.  Proc. Natl. Acad. Sci. 99:3523-3528, 2002. PMID: 11904416. PMCID: PMC122556 

  2. Dou, H., Mitra, S., and Hazra,TK.  Repair of oxidized bases from DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. J. Biol. Chem. 278:49679-49684, 2003. PMID: 14522990

  3. Wiederhold, L., Leppard JB., Kedar P.,Karimi-Busheri F., Rasouli-Nia, A., Weinfeld, M., Tomkinson, AE., Izumi, T., Prasad R., Wilson, SH., Mitra S., Hazra TK. AP Endonuclease-independent DNA base excision repair in human cells. Mol Cell, 15:209-220, 2004. PMID: 15260972

  4. Banerjee D, Mandal SM, Das A, Hegde ML, Das S, Bhakat KK, Boldogh I, Sarkar PS, Mitra S, Hazra TK. Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. J Biol Chem. 2011 286: 6006-16 PMID: 21169365 PMCID:PMC3057786

  5. Mandal SM, Hegde ML, Chatterjee A, Hegde PM, Szczesny B, Banerjee D, Boldogh I, Gao R, Falkenberg M, Gustafsson M, Sarkar PS, Hazra TK. 2012. The role of human DNA glycosylase NEIL2 and the single-strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of the mitochondrial genome. J Biol Chem. 287:2819-29. PMID: 22130663 PMCID: PMC3268439

Clinical Interests

Lung Diseases

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