ITC Facility Brochure 051916pdf
ITC Facility Brochure 051916pdf
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  1. Inhalation Toxicology Core FacilityAirway/Lung Physiology LaboratoriesThe airway/lung physiology laboratories are com-prised of a main lung function laboratory (284 ft2) and a large multi-functional laboratory (788 ft2), with an adjoining cell culture laboratory (291 ft2), complete with 4 cell culture hoods.Equipment:Whole-body plethysmography (Buxco, Inc.)Lung pressure-flow system (Buxco,Inc)Forced oscillation pressure-flow-volume system(FlexiVent/Sci-REQ)Sinus congestion/volume apparatusNO/CO/CO2 micro-analyzerNose-only inhalation apparatus (CH Technologies)Low-deadspace whole-body exposure chambersPressurized lung tissue fixation apparatusFume hood for volatiles/inhaled anestheticsHEPA-filter hood for allergen inhalationBiological Safety Cabinets and Cell Culture HoodsMeasurements/Techniques:In vivo unanesthetized plethysmography (n=12)In situ lung resistance/complianceLung dynamic compliance/elastance/resistanceForced-oscillation Flow-volume loopsExhaled NO and COBronchoalveolar lavage (BAL) fluid and cell countSinus congestion/inflammationWhole lung homogenates and histologyBAL/cell/tissue cytokines/chemokinesInhalation/Exposure Laboratories800 ft2, 3-room suiteFour 0.8 m3stainless steel Hinnar-type ex-posure chambersAnimal housing roomA remote lab for in-vitro cells culture expo-sureExposure protocols includeGas phase chemicals including organic chemical vapors such as 1,3-butadienePollutants such as ozone, nitrogen diox-ide, SO2, and CO Gas concentrations are controlled using mass flow controllersConcentrations are monitored by gas chro-matographyConcentrations of ozone, nitrogen dioxide, SO2, and CO are monitored by gas-specific meters. Cigarette Smoking/InhalationThe Jaeger-Baumgartner Cigarette Smoking Machine (with Human Puff Profile Pump ca-pability), is a fully automatic stand alone cig-arettesmokingdevicecomprisedofthreemain subassemblies, from top to bottom: the smoking machine, the electrical cabinet and a trolley with casters. Also included is the auto-loader with refillable 400+ cigarette capacity, power supply, rolling case and industrial computer unit with in-tegrated display panel (Siemens). The table-top platen groups all mechanical components that are necessary to automatically smoke cigarettes in restricted smoking condition according to ISO 3308 standard.Three tiered polycar-bonate smoke expo-sure chamber. This chamber is designed to hold 30 to 60 ani-mals per exposure.
  2. Inhalation Toxicology Core FacilityContact InformationDirector:Bill Ameredes, Ph.D.Phone:409-772-8104Email: btamered@utmb.eduManager: Lance Hallberg, Ph.D.Phone:409-772-3797Email:lmhallbe@utmb.eduWebsite: http://www.utmb.edu/itcfMission and OverviewThe Inhalation Toxicology Core Facility is designed to provide state-of-the-art capabilities for conducting exposures of experi-mental animals and in vitromodels to smoke, gas and vapor phase en-vironmental toxicants .The facili-ty operates under the auspices of the UTMB Sealy Center for Envi-ronmental Health and Medicine and is funded, in part, by UTMB institutional commitments.It serves as an institutional service core that provides support to all UTMB investigators and stu-dents.In addition, the facility pro-vides a foundation for inter-institution collaborative investiga-tions.The costs to investigators for performing exposures are based on offsetting expenses for facility personnel, equipment maintenance and replacement, ani-mal husbandry, supplies, etc.All exposure protocols must be ap-proved by the UTMB Chemical Safety Committee.If animals are involved, protocols must also re-ceive prior Inter/Intra Institutional IACUC approval.
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