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Anti-Ribonucleoprotein (RNP) Antibody (8000100338)
Test Mnemonic:
Specimen Requirements:
Collection:

SST ( serum separator tube) - yellow top

Container:

SST

Minimum Volume:

1 mL of serum

Storage/Transport:

Room temperature. Refrigerate 2-8'C if delay in transport

Specimen Preparation:

Within 2 hours of collection, centrifuge

Stability:

7 days refrigerated; indefinitely frozen

Causes for Rejection:

Improper collection, gross hemolysis.  Specimen container unlabeled or labeled incorrectly. No date and time of collection on requisition form.

Reference Range:

RNP antibody is seen in 95-100% of mixed connective tissue disease and is considered specific for this syndrome if other antibodies are negative; RNP is also present in 20-30% of systemic lupus erythematosus and 15-25% of progressive systemic sclerosis. RNP antigens also contain epitopes that are immunologically indentical to free Smith antigens, therefore, the Smith antibody response must be considered when interpreting RNP results.

Turnaround Time:

Test is performed daily, Monday through Friday

Methodology:

Multiplexing bead immunoassay

Performed:

Clinical Microbiology

Synonyms:

RNP, Ribonucleoprotein Antibody; ENA Antibodies

Clinical Indication:

Autoimmune disease testing

CPT 4 Code:

86235

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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