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Hemoglobinopathy Evaluation (LAB002057)
Test Mnemonic:

HGB EVAL
Specimen Requirements:
Collection:

 Routine Venipuncture.  EDTA (Lavender-top tube)
Container:

EDTA (Lavender-top tube)
Minimum Volume:

Minimum volume to be drawn is +/- 10% of manufacturer's stated capacity.
Storage/Transport:

Specimens should be stored refrigerated at 2 - 8°C.
Stability:

Specimen stable for 7 days if stored between 2-8°C. Prepare peripheral blood smear from specimen within 24 hours of collection.
Causes for Rejection:

Collected in wrong tube, clotted, mislabeled specimens, greater than 7 days old samples, no peripheral blood smear prepared within 24 hours, improperly stored samples.
Reference Range:
Age Sex Hb A Hb A2 Hb F Hb S Hb C Hb Other
0 up to 2 months Any 7.6 - 54.8 % 0.0 - 1.4 % 45.8 - 91.7 % 0% 0% 0%
2 months up to 3 months Any 14.7 - 70.1 % 0.0 - 2.0 % 32.7 - 85.2 % 0% 0% 0%
3 months up to 4 months Any 26.6 - 81.8 % 0.1 - 2.6 % 14.5 - 73.7 % 0% 0% 0%
4 months up to 5 months Any 43.0 - 89.5 % 0.8 - 3.0 % 4.2 - 56.9 % 0% 0% 0%
5 months up to 6 months Any 60.8 - 94.0 % 1.5 - 3.3 % 1.0 - 38.1 % 0% 0% 0%
6 months up to 9 months Any 78.2 - 96.6 % 1.8 - 3.5 % 0.9 - 19.4 % 0% 0% 0%
9 months up to 13 months Any 86.1 - 97.2 % 1.9 - 3.5 % 0.6 - 11.6 % 0% 0% 0%
13 months up to 24 months Any 85.1 - 97.7 % 1.9 - 3.5 % 0.0 - 8.5 % 0% 0% 0%
2 years up to 150 years Any 95.0 - 97.9 % 2.0 - 3.5% 0.0 - 2.1 % 0% 0% 0%

 
Turnaround Time:

Routine testing is batched on Tuesdays and Thursdays.  Maximum 7 day turnaround time (TAT).  STAT testing is available ONLY if needed prior to or post RBC transfusion.  STAT turnaround time is 4 hours, Monday-Friday if received BEFORE 1 pm.  STAT testing is not available on weekends or holidays.
Methodology:

Test panel includes, CBC and Differential, Tube Solubility (Sickle Screen), and Capillary Electrophoresis (CE).  PCR Alpha-Thalassemia 7 deletion and/or Alpha-Thalassemia deletion/duplication may reflexted.

  
Performed:

Hematology Division at the Department of Pathology
Synonyms:

HEMOGLOBIN ELECTROPHORESIS, HEMOGLOBINOPATHY, SICKLE CELL, THALASSEMIA, HEMOGLOBIN FRACTIONATION,  HEMOGLOBIN VARIANT
Clinical Indication:

Aids in diagnosis of patients presenting with certain hematological abnormalities (i.e. anemia, abnormal RBC morphology) or when hemoglobinopathy/thalassemia is suspected. 
CPT 4 Code:

83020, 83021, 85025, 85660

 
Note:

If applicable, state clinical information that is required to be provided with specimen.
When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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