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Anti-Chromatin Antibody (8000100936)
Test Mnemonic:
Specimen Requirements:

Serum separator tube (SST)


Serum separator tube (SST)

Minimum Volume:

1mL of serum


Refrigerate (2-8°C) up to 7 days; Samples should be frozen (<-20°C)

Specimen Preparation:

Within 2 hours of collection, centrifuge


Refrigerate (2-8°C) up to 7 days; Samples should be frozen (<-20°C)

Causes for Rejection:

Improper collection, gross hemolysis.  Specimen container unlabeled or labeled incorrectly. No date and time of collection on requisition form.

Reference Range:

Positive - Antibody detected. 

Negative - No antibody detected

Turnaround Time:

Test is performed daily,  Sunday through Friday


 Multiplexing bead immunoassay


Clinical Microbiology


Chromatin Antibody; ENA Antibodies

Clinical Indication:

Autoimmune disease screening

Patient Preparation :

 Routine venipuncture

CPT 4 Code:



The presence of anti-chromatin antibodies may be useful in the diagnosis of systemic lupus erythematous (SLE) or drug-induced lupus (DIL) and have been reported to be predictive of lupus nephritis.  

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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