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Epstein Barr Virus (EBV) Viral Capsid Antibody, IgG (8000100242)
Test Mnemonic:
Specimen Requirements:

Serum separator tube (SST)


Serum separator tube (SST)

Minimum Volume:

1 mL of serum


Refrigerate (2-8°C) up to 7 days; Samples should be frozen (<-20°C)

Specimen Preparation:

Within 2 hours of collection, centrifuge


Refrigerate (2-8°C) up to 7 days; Samples should be frozen (<-20°C)

Causes for Rejection:

Gross hemolysis, lipemia, bacterial contamination, improper collection of sample. Specimen container unlabeled or labeled incorrectly. No date and time of collection or no collector information on order.

Reference Range:


Positive - Indicates current or past infection with Epstein Barr virus. 
Negative - Indicates no serologic evidence of EBV infection. Cannot exclude acute EBV infection. 


Turnaround Time:

The test is performed daily, Sunday through Friday


Multiplex Bead Immunoassay

EBV-NA, EBV-EA and EBV VCA can be tested simultaneously with the multiplex assay.  If results are equivocal, a second sample should be collected and tested.


Clinical Microbiology


Epstein Barr Virus Antibody, IgG; EBV antibody, IgG; EBV IgG antibody; EBV Viral Capsid Antibody, IgG; EBVG

Clinical Indication:

IgG antibodies to VCA are normally present during acute and convalescent EBV disease. Antibody levels tend to rise and peak after 3-4 weeks, then decline and usually persist for life.  Order in conjunction with VCA IgM antibodies and anti-EBNA antibodies to differentiate acute, recent, and past EBV infection.

Patient Preparation :

Routine venipuncture

CPT 4 Code:



Infection by EBV results in the production of antibodies to four different and distinct antigenic complexes: EBV induced Nuclear Antigen (NA), Early Antigen (EA), Viral Capsid Antigen (VCA), and Membrane Antigen. Because of the complex relationship that exists between the EBV/host reaction and clinical manifestation, tracking of EBV antibody patterns may assist in diagnosis of EBV infection. Antibody response profiles for the different EBV antigens demonstrate a characteristic pattern for silent primary or persistent latent EBV infection.

Previously positive patients do not require repeat testing.


When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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