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HSV 1/2, VZV NAAT (8000100463)
Test Mnemonic:
Specimen Requirements:

Swab of lesion or ocular swab.  Place swab in viral transport medium or univeral transport medium.

Test Included:

Herpes simplex virus type 1, Herpes simplex virus type 2, and Varicella zoster virus detection.


Collect lesions by swabbing the lesion base. Collect ocular samples by asceptic manner. The swab is put into VTM/UTM which is stable for up to 48 hours at room temperature (up to 30C). See Storage/Transport requirements.


Viral Transport Medium (VTM) or Universal Transport Medium (UTM)

Minimum Volume:

Adequate cellular material for the assay.


Specimen should be delivered to the lab ASAP. Storage for up to 48 hours at room temperature. Transport specimen refrigerated when possible.

Specimen Preparation:

Transfer swab to a VTM (Viral Transport Medium)  or UTM (Universal Transport Medium) tube.


The swab specimen is stable for up to 48 hours at room temperature (up to 30C) or up to 7 days prior to processing when stored at 2-8C or -20C. 

Causes for Rejection:

Improper collection, use of wooden swabs, unlabeled or mislabeled samples, no date and time of colelction or no collector information in order.

Reference Range:


Turnaround Time:

Test is performed once daily.


Helicase-dependent amplification


Clinical Microbiology


HSV, HSV1, HSV2, HSV-1, HSV-2, Herpes, Varicella, Zoster, Varicella Zoster, VZV, Chickenpox, Shingles

Clinical Indication:

 Suspected infection with Herpes simplex viruses or Varicella zoster virus from cutaneous or mucocutaneous lesions. Suspected infection with HSV or VZV from ocular specimens.

CPT 4 Code:

87529, 87798



All three assays are performed on each sample, the order must include all three viruses in it.


When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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