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RPR (Quantitative) (8000100063)
Test Mnemonic:
Specimen Requirements:

Serum separator tube (SST)

Red top serum tube with no additive


Serum separator tube (SST)

Red top serum tube with no additive

Minimum Volume:

1 ml 


Refrigerate (2-8°C) up to 5 days; Samples can be frozen (<-20°C)

Specimen Preparation:

Within 2 hours collection, centrifuge. Serum collected in a red top tube should be removed from the red cells if testing will be delayed.


Refrigerate (2-8°C) up to 5 days; Samples can be frozen (<-20°C)

Causes for Rejection:

Insufficient quantity, gross hemolysis, lipemia. Specimen container unlabeled or labeled incorrectly. No date and time of collection or collector completed.

Reference Range:


Turnaround Time:

Testing is performed daily, Sunday-Friday.

L&D/Newborn specimens are tested 7 days a week.




Clinical Microbiology


RPR (Quant), RPRQN

Clinical Indication:

A qualitative and semiquantitative nontreponemal flocculation test for the detection of reagin antibodies in serum.

CPT 4 Code:



Specimens with positive Syphilis Total results are automatically tested for RPR titer and a confirmatory treponemal test (Treponema pallidum partical agglutination test).

For patients diagnosed with syphilis (i.e., positive Total and confirmatory test), the CDC recommends that response to therapy be assessed by RPR test (a 4-fold decline in titer, or undetectable RPR titer) after 6 months. 

VDRL test is performed on CSF samples as a Sendout test for patients with positive serum test results, only.

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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