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HLA Typing - Disease Association (8000101634, LAB002285)
Test Mnemonic:


Specimen Requirements:
Test Included:

Molecular HLA Typing of specific HLA locus or loci to confirm the presence or absence of specific HLA Antigen(s) or Allele(s)




(1)10mL Pale Yellow tube tube with Acid Cirate Dextrose (ACD) additive OR

(1) 7mL or 5mL Lavender (EDTA) tube

Minimum Volume:



Room temperature. Do not refrigerate.

Specimen Preparation:

Routine venipuncture


Deliver immediately to Tissue Antigen Laboratory or Laboratory Services Specimen Management.

Causes for Rejection:

Incorrect tube, incorrect label, insufficient volume.

Reference Range:


Turnaround Time:

5 days


Molecular HLA Typing


Identification of specified HLA antigen(s) or allele(s.) 

Please indicate which HLA antigen(s) to be identified.


Tissue Antigen Laboratory


HLA X, X-Renal, B5701, B27, B*57:01, B5801, B*58:01, drug hypersensitivity

Clinical Indication:

Need to confirm the presence or absence of HLA antigen(s) or allele(s) associated with a particular disease or drug-induced adverse reaction.

CPT 4 Code:

81381: One HLA Allele or allele group.

81374: One HLA Antigen equivalent.

81370: HLA Class I and Class II typing.

81372: HLA Class I typing.

81375: HLA Class II typing


Indicate which HLA Antigen(s) / Allele(s) to be tested among the listed options or in order comments.

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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