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CREATININE CLEARANCE, urine (087-0037)
Test Mnemonic:


Specimen Requirements:


Blood: Routine venipuncture. Collect 7mL of blood in SST (gel barrier) or red topped vacutainer tube. (Min: 3mL of blood) and 20mL aliquot of timed urine collection. (Min.: 3mL of urine).    

24-hour Urine Specimen: Discard the first early morning specimen. Start timing from this point. Collect all urine voided during the next 24 hours in a urine container that is free of preservatives. Note the time that the last specimen is collected during this 24-hour period. This is the finish time that should be recorded on the lab request slip.



Urine: Refrigerated until delivered to Sample Management.  Blood: Room temperature if delivered to Sample Management within 2 hours of collection.

Specimen Preparation:

Urine: All samples should be stored refrigerated during collection and until delivered to the laboratory.   Blood: Allow specimen to clot completely at room temperature. Centrifuge to separate serum from cells within 2 hours of collection. Transfer serum from collection tube to labeled plastic transport tube. 


Blood: Room temperature for ≤3 days, Refrigerated   for ≤5 days, Frozen for indefinite.  

Causes for Rejection:

Urine: Specimen collected in container with preservative, incomplete and/or incorrect sample identification, improper storage/transport            Blood:  Incomplete and/or incorrect sample identification, improper storage/transport, and gross hemolysis or lipemia.                                                    

Reference Range:

By report (reports may vary based on instrumentation, patient age and sex)

Turnaround Time:

Routine: 8 hours; ASAP: 4 hours; STAT: 1 hour.


Spectrophotometric Two-point Rate Reaction


Clinical Chemistry  

CPT 4 Code:



Indicate total volume of urine and time of collection on requisition. Serum specimen required within 24 hours of the urine collection.

If applicable, state clinical information that is required to be provided with specimen.

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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