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Breast Biopsy (98305)
Test Mnemonic:
Specimen Requirements:

Per ASCO/CAP guidelines breast tissue must be fixed in formalin for a minimum of 6 hours to a maximum of 48 hours before undergoing HER2 testing. 

The time must be documented on the specimen container and in the clinical history in Epic Beaker.  


Pre-filled containers with 10% neutral buffered formalin.


Submit biopsy in 10% neutral buffered formalin in a container labeled with the patient's first and last names, unit history number and specimen identification.

Causes for Rejection:

Electronic order must be submitted in Beaker and must contain the specimen source, time of the biopsy and the time submitted in formalin, clinical history and diagnosis this can be cause for rejection or delay in processing of the specimen.  Along with contaminated containers.

Reference Range:
Turnaround Time:

Routine: 24 hours.


Breast biopsy, core needle biopsy.

CPT 4 Code:


When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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