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Rh Immune Globulin (10006354)
Test Mnemonic:


Specimen Requirements:
Test Included:

A Type and Screen must be completed before releasing RHIG for administration.  In post-partum patients, FMH and/or FHS testing is also required to determine the appropriate dosage.   Cord Blood testing of the infant is necessary to determine if a post-partum patient is a candidate for RHIG.


RHIG is refrigerated while in the blood bank;  it should be kept at ambient temperature when it is dispensed to the floor for the patient.  It should be administered as soon as patient identity is confirmed after it is dispensed.

Causes for Rejection:

Rh positive patients, patients who have already formed immune anti-D, or Rh negative maternity patients who give birth to Rh negative infants are not candidates for RHIG

Reference Range:
Turnaround Time:

RHIG can be ordered and picked up 24 hours per day from the Blood Bank lab, 4.404 Clinical Services Wing (CSW).


Rh Immunoglobulin;  RhoGAMTM; Rho(D) Immune Globulin, Human

Clinical Indication:

Used to reduce the probability of sensitization and formation of immune anti-D antibodies within 72 hours of exposure to Rh positive red blood cells or platelets in an Rh negative patient.  Rh Immune Globulin (RHIG) is administered routinely in the US to female Rh negative patients after the birth of an Rh positive infant, miscarriage, abortion, amniocentesis and other invasive procedures, and antenatal administration at approximately 28 weeks gestation. 

 RHIG may also be administered to any Rh negative  patient, regardless of gender or age, following transfusion of Rh positive platelets or red cells. The Blood Bank physicians can provide consultation regarding appropriate dosage and administration guidelines for patients who have been transfused with Rh positive cellular components.

WinRho is a similar human Rh Immune Globulin product available from the pharmacy and typically used in the treatment of idiopathic thrombocytopenia (ITP).  It may at times be used as a substitute for RHIG when more than a single dose is required or when intravenous administration is desired.  WinRho from the pharmacy should not be routinely substituted for RHIG in maternity patients because of the unnecessary additional cost and dosage.

CPT 4 Code:



FMH and/or FHS testing will be used to determine appropriate RHIG dosage in postpartum patients.  The blood bank physicians are available to provide telephone consultation regarding dosage for Rh negative patients who have been transfused with Rh positive cellular blood products.

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Components of the organ or disease panels may be ordered individually. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent.
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