J.Sowers James Sowers
Year in Program: GY4
Undergrad University: Johns Hopkins University
Mentor: Ping Wu, MD, PhD
Graduate Program: Neuroscience

James Sowers

  • Developing mass spectrometry-based assays to follow epigenetic reprogramming in glioblastoma stem cells and human neural stem cells (hNSC) and to measure metabolic changes resulting from tissue damage and inflammation.
  • To better understand the pathophysiology of neurodegeneration due to disease or trauma and ultimately to develop better strategies for treating patients with neurodegenerative disorders.
  • Graduated with University Honors, Johns Hopkins University (2013)
  • Graduated with Departmental Honors in Chemistry, Johns Hopkins University (2013)
  • Dean's List (2009-2013)
  • Golden Key Society
  • Sowers JL, Mirfattah B, Xu P, Tang H, Park IY, Walker C, Wu P, Laezza F, Sowers LC, Zhang K. (2015) Quantification of Histone Modifications by Parallel-Reaction Monitoring: A Method Validation. Anal Chem. 87(19): 10006-14
  • Sowers JL, Johnson K. M., Conrad C., Patterson J. T., Sowers, L.C. (2014) “The Role of Inflammation in Brain Cancer” in Inflammation and Cancer, Aggarwal B. B., Sung B., Gupta S. C. , Eds. Springer Basel AG. Adv Exp Med Biol. 816:75-105
  • Darwanto, A., Theruvathu, J. A., Sowers, J. L., Rogstad, D. K., Pascal, T., Goddard, WA III, and Sowers, L. C. (2009) Mechanism of base selection by single-stranded selective monofunctional uracil-DNA glycosylase. J. Biol. Chem. 284, 15835-46.
  • Sowers JL, Hawkins BE, Dewitt DS, Prough DS, Wu P, Zhang K. Changes in Brain Protein Levels Following Traumatic Brain Injury: A Longitudinal Proteomic Study. National Neurotrauma Society Meeting 2017
  • Sowers JL, Hawkins BE, Dewitt DS, Prough DS, Wu P, Zhang K. Changes in Brain Protein Levels Following Traumatic Brain Injury: A Longitudinal Proteomic Study, Focus on Epigenetic Changes. Society of Chinese Bioscientists in America 2017
  • Sowers JL, Hawkins BE, Dewitt DS, Prough DS, Wu P, Zhang K. Changes in Brain Protein Levels Following Traumatic Brain Injury: A Longitudinal Proteomic Study, Focus on Epigenetic Changes. American Physician Scientist Associates South Regional Meeting 2017
  • Sowers JL, Wu Ping, Sowers LC Epigenetic monitoring of human neural stem cells by mass spectrometry using heavy isotope labeling. MD/ PhD Retreat UT Austin 2013