UTMB Home UTMB MD-PhD Program Current Students Student Profiles Kyle Wilson Kyle D. WilsonYear in Program: MY3Undergrad University: Southern Nazarene University Mentor: Robin Stephens, PhDGraduate Program: Microbiology and Immunology Kyle Wilson Research Interests My dissertation research focused on the host-immune response to Plasmodium chabaudi, a rodent malaria parasite that manifests many of the same parasite-specific and immune-specific properties seen in human Plasmodium falciparum infection. My project aimed to describe the major behavioral phenotype and immunocellular events regulating the severity of disease in IL-10-deficient mice, who succumb to this normally mild infection. My studies defined a very severe, hyper-inflammatory phenotype in IL-10-deficient mice that was consistent with other murine models of experimental cerebral malaria, and was characterized by an increase in innate immune cell populations within the vasculature of the brain, as well as wide-spread intravascular coagulation and glial cell activation, suggestive of widespread neuropathology. I intend to use the skills learned during my PhD to further research geared towards improving patient-centered outcomes in the clinical setting. Honors and Awards President's Scholarship, Southern Nazarene University (2007-2011) Freshman Chemistry Student of the Year, Southern Nazarene University (2008) University Marshal, Southern Nazarene University (2009-2010) 2nd Place at 2010 South-Central Regional BBB Conference (Poster), Southern Nazarene University (2010) Gene Coburn Memorial Scholarship, Southern Nazarene University (2010) T32 Trainee in Emerging and Tropical Infectious Diseases, UTMB (2014) James W. McLaughlin Pre-doctoral Fellow, UTMB (2015) James W. McLaughlin Travel Awardee for Best Poster, UTMB (2015, 2016) Best Poster Award, 20th Annual Wood’s Hole Immunoparasitology Meeting (WHIP 2016), Marine Biological Laboratory, Wood’s Hole, MA, USA Jeane B. Kempner Predoctoral Scholar Award, UTMB (2016) Robert Shope PhD Endowed Scholarship, UTMB (2016) Who's Who Among Students In American Universities & Colleges (2017) George Sealy Research Award in Neurology (2018) Publications Van der Wel H, Johnson JM, Xu Y, Karunaratne CV, Wilson KD, Vohra Y, Boons GJ, Taylor CM, Bendiak B, West CM. (2011) Requirements for Skp1 Processing by Cytosolic Prolyl 4(trans)-Hydroxylase and α-N-Acetylglucosaminyltransferase Enzymes Involved in O2 Signaling in Dictyostelium. Biochemistry. 50, 1700-1713. Wilson KD, Stutz SJ, Ochoa LF, Valbuena GA, Cravens PD, Dineley KT, Vargas G, Stephens R. (2016) Behavioral and Neurological Symptoms accompanied by Cellular Neuroinflammation in IL-10-deficient Mice infected with Plasmodium chabaudi. Malaria Journal. 15(1):428. Opata MM, Ibitokou SA, Carpio VH, Marshall KM, Dillon BE, Carl JC, Wilson KD, Arcari CM, Stephens R. (2018) Protection by and maintenance of CD4 effector memory and effector T cell subsets in persistent malaria infection. PLoS Pathog. In Press. Wilson KD, Ochoa LF, Solomon OD, Pal R, Cardona SM, Carpio VH, Keiser PH, Cardona AE, Vargas G, Stephens R. (2018) Elimination of Intravascular Thrombi Prevents Early Mortality and Reduces Gliosis in Hyper-inflammatory Experimental Cerebral Malaria. Journal of Neuroinflammation. Under Review. Presentations Wilson, K.D. (2009), Site-directed Mutagenesis of Cysteines in Skp1 to Elucidate its Role in Prolyl 4-Hydroxylase-Dependent O2-Signaling in Dictyostelium. University of Oklahoma Health Sciences Center. Presented at OUHSC, SNU Research Symposium and 2010 BBB Regional Conference. Wilson, K.D. (2010), Neodymium Conjugation of HLA B*0702 for Use in Serum Antibody Identification and Quantitation. University of Oklahoma Health Sciences Center. Presented at OUHSC and 2011 BBB Regional Conference. Wilson, K.D. (2015), Decreased Animal Behavior and Altered Cellular Profile in Brains of IL-10-Deficient Mice Infected with Plasmodium chabaudi chabaudi (AS). Gordon Research Conference on Tropical Infectious Diseases and the 2015 IHII/McLaughlin Colloquium, University of Texas Medical Branch, Galveston, TX. Wilson, K.D. (2016), Behavioral and Neurological Symptoms accompanied by Cellular Neuroinflammation in IL-10-deficient Mice infected with Plasmodium chabaudi. 20th Annual Wood’s Hole Immunoparasitology meeting (WHIP 2016), Marine Biological Laboratory, Wood’s Hole, MA, USA. Wilson, K.D. (2017), TNF Mediates Fibrinogen-associated Astrocyte Activation in IL-10-deficient Mice Infected with Plasmodium chabaudi. 2017 IHII/McLaughlin Colloquium, University of Texas Medical Branch, Galveston, TX.