Department of Neuroscience, Cell Biology, & Anatomy
4.212B Research Building 17Route
: 0620 |
409-772-9858 | Fax
: (409) 747-2200 | firstname.lastname@example.org
Affiliations The Mitchell Center for Neurodegenerative DiseasesMoody Center for Traumatic Brain & Spinal Cord Injury ResearchCenter for Addiction Research
Education and Training
PhD in Neuroendocrinology, UTMB, Galveston, TX
Post-Doctoral in Molecular Neuroscience & Gene
Transfer, University of Florida College of Medicine, Gainsville, FLBM (equivalent to MD), Peking University, Bejing, China
My laboratory has been interested in both basic science
research and translational research in the field of neuroscience.
Particularly we focus on understanding the molecular mechanisms of
plasticity, multipotential and trophic factor secretion of neural stem
cells (NSCs); as well as applications of NSCs to model and treat
To learn the biology of human and rodent NSCs, we focus
on cellular and molecular mechanisms underlying fate specification of
NSCs, and develop novel strategies to guide them to generate specific
types of neurons, oligodendrocytes and astrocytes.To model neural diseases, we are interested in applying
both human and rodent NSCs and their differentiated neural cells to
mimic traumatic brain or spinal cord injury, alcohol and cocaine abuse,
neural infection (such as Zika virus, henipavirus, and HIV), and
neurodegenerative diseases such ALS. Specific efforts are also devoted
to learn the interaction between NSCs and other types of cells in a
To treat neural diseases, we use NSCs to screen
potential drugs to protect human neurons. We also develop novel
strategies to transplant exogenous NSC-differentiated neuronal cells
into traumatically injured or degenerated brains and spinal cords, as
well as to mobilize endogenous NSCs to replace lost neurons in a cell
The outcome of our studies will provide insights towards
development of stem cell-related therapy to treat neurological
diseases like ALS, traumatic brain and spinal cord injury,
neuroinfection and addiction.
Wu, P. (corresponding author), Tarasenko, Y.I.,
Gu, Y., Huang, L.-Y., Coggeshall, R. and Yu, Y. Region-specific
generation of cholinergic neurons from fetal human neural stem cells
grafted in adult rat. Nat. Neurosci. 5(12):1271-1278, 2002.
Xu, Y., Gu, Y., Xu, G.Y., Wu, P., Li, G.-W. and
Huang L,-Y. Adeno-associated viral transfer of opioid receptor gene to
primary sensory neurons- a novel strategy to increase opioid
antinociception. Proc. Nat. Acad. Sci. USA 100:6204-6209, 2003.
Gao, J., Coggeshall, R., Tarasenko, Y.I. and Wu, P.
Human neural stem cell-derived cholinergic neurons innervate muscle in
motoneuron deficient adult rats. Neurosc. 131:257-262 (Rapid Report),
Gao, J., Prough, D.S., McAdoo, D.J., Grady, J.J., Parsley, M.O., Ma, L., Tarasenko, Y.I. and Wu, P.
Transplantation of primed human fetal neural stem cells improves
cognitive function in rats after traumatic brain injury. Exp. Neurol.
201:281-92 (featured on the cover), 2006.
Tarasenko, Y.I., Nie, L., McAdoo, D.J., Johnson, K.M., Hulsebosch, C.E., Grady, J.J. and Wu, P.
Human fetal neural stem cells grafted into contusion-injured rat
spinal cord improve behavior. J. Neurosc. Res. 85:47-57, 2007.
Thonhoff, J.R., Lou, D.I., Jordan, P.M., Zhao, X. and Wu, P. Compatibility of human fetal neural stem cells with bioengineering hydrogels in vitro. Brain Res. 1187:42-51, 2008.
L., Gao, J., Hooten, K.G., Wang, E., Thonhoff, J.R., Gao, T. and Wu, P. Critical role of PI3K/Akt/GSK3beta in
motoneuron specification from human neural stem cells in
response to FGF2 and EGF. PLoS ONE 6:e23414, 2011.
E., Gao, J., Denner, L., Dunn, T., Parles, M., Zhang, L. and Wu, P. Molecular mechanisms underlying protective effects of
neural stem cells against traumatic axonal injury. J. Neurotrauma 29:295-312, 2012.
Li, B., Shi, Y., Shu, J., Gao, J., Wu, P. and
Tang, S.-J. Wingless-type mammary tumor virus integration site family,
member 5A (Wnt5a) regulates human immunodeficiency virus type 1
(HIV-1) envelope glycoprotein 120 (gp120)-induced expression of
pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein
kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways.
J. Biol. Chem. 288:13610-13619, 2013.
Yun, T., Park, A., Yun, T.E., Hill, T.E., Pernet, O.,
Beaty, S.M., Juelich, T.L., Smith, J.K., Zhang, L., Wang, Y.E., Vigant,
F., Gao, J., Wu, P., Lee, B. and Freiberg, A.N. Efficient
reverse genetics reveals genetic determinants of budding and fusogenic
differences between Nipah and Hendra virus and enables real-time
monitoring of viral spread in small animal models of henipavirus
infection. J. Virol. 89:1242-53, 2015.
Link to PubMed Publications