Department of Neuroscience, Cell Biology, & Anatomy
10.104 Medical Research Building (MRB)Route
: 1043 | Tel:
Department of Biochemistry & Molecular Biology,
Sealy Center for Cancer Cell Biology,
Department of Internal Medicine
Education and Training
PhD in Reproductive Biology, All India Institute of Medical Sciences, Delhi, India
Post-Doctoral in Endocrinology, Medical College of Georgia, Augusta, Georgia
MS in Zoology, Delhi University, Delhi, India
BS in Zoology, Delhi University, Delhi, India
Basic Science Research: Dr Pomila Singh, received
her PhD degree in Endocrinology and Biochemistry, and trained as a
Postdoctoral Fellow in neuroendocrinology. She was recruited as an
Assistant Professor by UTMB in 1983, and concurrently served as the
Director of Hormone receptor laboratory, till 1990. Within 7 years of
Joining UTMB, she was promoted and tenured to the level of Full
Professor. For the past 33 years, Dr Singh has remained continuously
funded as the PI of several RO1 grants from the NCI. Her laboratory has
published more than 137 peer-reviewed papers and invited articles/book
chapters. She has expertise in the areas of cell and molecular biology
of solid tumors, cancer stem cells, colon carcinogenesis and
chemoprevention. She has trained many graduate students and
post-graduate trainees. Her laboratory is credited with several new
discoveries and paradigm-shifting concepts. She has so far received 5
patents for cancer treatment and diagnosis. Three additional patents
have been filed, and one of her technologies was licensed in 2012.
The goals of her currently funded grant
are to delineate mechanisms mediating inhibitory effects of chemo
preventive dietary agents against cancer stem cells in colon cancers.
Mechanisms by which DCLK1, a cancer stem cell marker, exerts
tumorogenic/metastatic effects on colon cancer and pancreatic cancer
cells is being examined. Her laboratory is also developing
diagnostic/prognostic markers for cancer, and developing strategies for
targeting cancer cells.
Medical and Graduate Education:
Besides her research contributions, Dr Singh is also serving as the
Program Director of Cell Biology Graduate Program, and she is heavily
involved in didactic teaching for both the medical and graduate
schools. She has served on several study sections for the NIH and the
VA, and has received research, teaching and service awards. She was
named the Edna Seisenheimer Professor of Cancer Studies, and has
received a teaching professorship. She is an active member of the
American Gastroenterological Association (AGA) and American Association
of Cancer Research (AACR), since 1983. The AGA Institute named her a
Senior AGA Fellow, in 2007.
Singh, P., Muldoon, T.G. Specific
estrogen-sensitive alterations in anterior pituitary cytoplasmic and
nuclear estrogen receptors activated by LHRH. Neuroendocrinology
Singh, P., Owlia, A., Varro, A., Dai, B.,
Rajaraman, S., Wood, T. Gastrin gene expression is required for the
proliferation and tumorigenicity of human colon cancer cells. Cancer
Res. 56(18):4111-4115, 1996.
Singh, P., Velasco, M., Given, R., Varro, A.,
Wang, T. Progastrin Expression Predisposes Mice to Development of Colon
Carcinomas and Andenomas in Respose to AOM. Gastroenterology
Wu, H., Rao, G.N., Dai, B., Singh, P. Autocrine
Gastrins in Colon Cancer Cells Up-regulate Cytochrome c Oxidase Vb
(Cox Vb) and Down-regulate Efflux of Cytochrome c (cyt c) and
Activation of Caspase 3. J. Biol. Chem. 275(42):32491-32498, 2000.
Shen, Q., Singh, P. Identification of a novel
SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and
AP-1 in regulating promoter activity in CaCo2 cells. Oncogene
Singh, P., Wu, H.,
Clark, C. and Owlia, A. Annexin II binds progastrin and gastrin
like peptides, and mediates growth factor effects of
autocrine and exogenous gastrins on colon cancer and
intestinal epithelial cells. Oncogene 26(3):425-440, 2007.
Umar, S., Sarkar, S., Wang, Y., Singh, P. Functional
cross-talk between beta-catenin and NFkappaB signaling pathways in
colonic crypts of mice in response to progastrin. J. Biol. Chem.
Sarkar, S., Swiercz, R.,
Kantara, C., Hajjar, K.A. and Singh, P. Annexin A2 mediates
up-regulation of NFkB, beta-catenin, and stem cell in response
to progastrin in mice and HEK-293 cells. Gastroenterology
Kantara, C., O'Connell, M., Sarkar, S., Moya, S., Ullrich, R., Singh, P.
Curcumin promotes autophagic survival of a subset of colon cancer stem
cells, which are ablated by DCLK1-siRNA. Cancer Res. 74(9):2487-98,
O'Connell, M.R., Sarkar, S., Luthra, G.K., Okugawa, Y., Toiyama, Y., Gajjar, A.H., Qiu, S., Goel, A., Singh, P.
Epigenetic changes and alternate promoter usage by human colon cancers
for expressing DCLK1-isoforms: Clinical Implications. Sci. Rep.
Link to PubMed Publications