Rinat O. Esenaliev, PhD Professor

Rinat O. Esenaliev, PhD Department of Neuroscience, Cell Biology, & Anatomy
Director, Laboratory for Optical Sensing and Monitoring
Director, High-resolution Ultrasound Imaging Core
4.410C Research Building 21 | Route: 1156 | Tel: 409-772-8144 | riesenal@utmb.edu

Affiliations: Department of Anesthesiology, Center for Biomedical Engineering,
UTMB Cancer Center


Education and Training

PhD in Applied Biophysics, Institute of Spectroscopy, Russian Academy of Sciences
MS in Applied Biophysics, Moscow Institute of Physics and Technology
BS in Theoretical and Experimental Physics, Moscow Institute of Physics and Technology

Research Interests

Dr. Esenaliev's research is in the field of bioengineering and biophysics.  The main focus of his research is in novel applications of biophotonic technology for non-invasive and continuous monitoring of multiple important physiological parameters and for non-invasive, efficient cancer therapy.  Dr. Esenaliev is developing high-resolution optical techniques (such as optoacoustic technique, optical coherence tomography) for non-invasive, continuous, and absolute measurement of cerebral and central venous blood oxygenation, total hemoglobin concentration, and blood glucose concentration.  His research interests include novel cancer therapy based on interaction of nanoparticles with electromagnetic or ultrasound radiation. Successful development of these techniques will substantially improve treatment of acute life-threatening illnesses, diabetes, and cancer. 

Major Inventions and Research Interests: 1.) Novel diagnostic imaging modality: Optoacoustic/Photoacoustic Imaging and Tomography. 2.) Nanoparticle-based therapy of tumors and drig delivery in tumors using laser, radiofrequency, microwave, or ultrasound radiation. 3.) Real-time, noninvasive optoacoustic/photoacoustic monitoring of tissue properties. 4.) Noninvasive, continuous monitoring of blood oxygenation including oxygenation in cerebral and central veins. 5.) Noninvasive measurement and monitoring of total hemoglobin concentration. 6.) Noninvasive monitoring of blood glucose concentration with Optical Coherence Tomography.

Selected Publications

Chumakova O.V., Liopo A.V., Andreev V.G., Cicenaite I., Evers B.M., Chakrabarty S., Pappas T.C. and Esenaliev, R.O. Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo. Cancer Letters, 261(2), pp. 215-225, 2008.

Esenaliev, R.O. and Prough D.S. Noninvasive Monitoring of Glucose Concentration with Optical Coherence Tomography. In: “Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues”, ed. by Valery Tuchin, Taylor and Francis, 2009.

Petrova I.Y., Petrov, Y.Y., Esenaliev, R.O., Deyo, D.J., Cicenaite, I. and Prough, D.S. Noninvasive monitoring of cerebral blood oxygenation in ovine superior sagittal sinus with novel multi-wavelength optoacoustic system. Optics Express, v.17(9), pp. 7285-7294, 2009.

Esenaliev, R.O. Biomedical Optoacoustics. Journal of Innovative Optical Health Sciences, Special Issue in Honor of Steven L. Jacques for His 60th Birthday, published on-line in 2010; v.4(1) pp. 39-44, 2011.

Petrov I.Y., Petrov, Y.Y., Prough, D.S., Deyo, D.J., Cicenaite, I. and Esenaliev, R.O. Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood. Biomedical Optics Express, published on-line in 2011; v.3(1), pp. 125-136, 2012.

Petrov I.Y., Petrov, Y.Y., Prough, D.S., Cicenaite, I., Deyo, D.J. and Esenaliev, R.O. Optoacoustic monitoring of cerebral venous blood oxygenation through intact scalp in large animals. Optics Express, v.20(4), pp. 4159-4167, 2012.

Figueiredo M. and Esenaliev, R.O. PLGA nanoparticles for ultrasound-mediated gene delivery to solid tumors. Journal of Drug Delivery. Special Issue “Nanoparticles for targeted delivery of active agents against tumor cells”, v. 2012, 767839, pp. 1-20, 2012.

Prough D.S. and Esenaliev, R.O. Monitoring the brain to save the kidneys. Critical Care Medicine. v. 41(2), pp.671-672, 2013.

Petrov A., Wynne, K.E., Parsley, M.A., Petrov, I.Y., Ruppert, K.A., Prough D.S., DeWitt D.S. and Esenaliev, R.O. Optoacoustic detection of intra- and extracranial hematomas in rats after blast injury. Photoacoustics, v. 2, pp.75-80, 2014.

Melentiev P.N., Afanasiev, A.E., Kuzin, A.A., Gusev, V.M., Kompanets, O.N., Esenaliev, R.O., Balykin V.I. Split Hole Resonator: A nanoscale UV light source, Nano Letters, v.16, pp.1138-1142, 2016.

Link to PubMed Publications