Department of Neuroscience, Cell Biology, & Anatomy
2.104D Medical Research Building (MRB)
: 1069 | Tel:
(409) 772-1190 | email@example.com
Education and Training
PhD in Molecular and Developmental Biology, University of Toronto
Post-Doctoral in Synaptic Plasticity, California Institute of Technology
MS in Molecular Biology, University of Toronto
HIV-associated neurological disorders (NeuroAIDS): HIV-1
infection causes a spectrum of neurological/cognitive complications
(NeuroAIDS), but the pathogenic mechanisms are poorly understood and
effective therapies are not available. NeuroAIDS presents a huge
opportunity for both basic and translational research. We are interested
in the pathogenic processes that contribute to the development of
NeuroAIDS. A focal point of our NIH-funded current research is on the
HIV-associated pathological pain, a neurological complication suffered
by many millions of HIV-1/AIDS patients. In collaboration with other
investigators (including Dr. Ben Gelman and Sue Carlton at UTMB), we
are working to elucidate the molecular, synaptic and glial mechanisms
by which HIV-1 infection and the co-morbid factors (e.g. drugs of abuse
and antiretroviral treatments) cause the pathological pain. In
particular, we focus on the potential role of Wnt signaling in the
pathogenesis. With the new knowledge generated, we aim to develop
innovative therapeutics to treat the pain syndrome. We use
interdisciplinary methodologies, including molecular biology, neuron
imaging, gene knockout, electrophysiology and behavioral testing, in
our studies on animal models, postmortem patient specimens and primary
cultures of neurons and glia. Students/postdocs and other research
scientists who are interested in joining the exciting projects are
welcome to contact Dr. Tang.
Tang, S. J., Meulemans, D., Vazquez, L., Colaco, N.,
Schuman., E. A role for a rat homolog of staufen in the transport of
RNA to neuronal dendrites. Neuron. 32:463-75, 2001
Tang, S. J., Hoodless, P. A., Lu, Z., Breitman, M. L.,
McInnes, R. R., Wrana, J. L., Buchwald, M. The Tlx-2 homeobox gene is a
downstream target of BMP signaling and is required for mouse mesoderm
development. Development. 125:1877-87, 1998
Tang, S.J., Reis, G., Kang, H., Gingras, A. C.
Sonenberg, N. and Schuman, E. M. A Rapamycin-Sensitive Signaling
Pathway contributes to long-term synaptic plasticity in the
hippocampus. Proc. Natl. Acad. Sci. USA 99:467-472, 2002.
Park, C. S., Gong, R., Stuart, J. and Tang, S.J.
Molecular network and chromosomal clustering of genes involved in
synaptic plasticity in the hippocampus. J. Biol. Chem.
Gong, R., Park, C. S., Abbassi, N. R. and Tang, S.J.
Roles of glutamate receptors and the mTOR signaling pathway in
activity-dependent dendritic protein synthesis in hippocampal neurons.
J. Biol. Chem. 281:18802-18815, 2006.
Chen, J., Park, C. S. and Tang, S.J. Activity-dependent synaptic WNT release regulates hippocampal long-term potentiation. J. Biol. Chem. 281:11910-11916, 2006.
Li, B., Zhong, L., Yang, X., Andersson, T., Huang, M. and Tang, S.J. WNT5A signaling contributes to A-beta-induced neuroinflammation and neurotoxicity. PLoS One. 6:e22920, 2011.
Wan, X.Z., Li, B., Li, Y.C., Yang, X.L., Zhang, W., Zhong, L. and Tang, S.J.
Activation of NMDA receptors upregulates a disintegrin and
metalloproteinase 10 via a Wnt/MAPK signaling pathway. J Neurosci.
Shi, Y., Gelman, B.B., Lisinicchia, J.G. and Tang, S.J.
Chronic-pain-associated astrocytic reaction in the spinal cord dorsal
horn of human immunodeficiency virus-infected patients. J Neurosci.
Shi, Y., Shu, J., Gelman, B.B., Lisinicchia, J.G.and Tang, S.J. Wnt Signaling in the Pathogenesis of Human HIV-Associated Pain Syndromes. J Neuroimmune Pharmacol. 8:956-964, 2013.
Li, B., Shi, Y., Shu, J., Gao, J., Wu, P. and Tang, S.J.
Wingless-type mammary tumor virus integration site family, member 5A
(Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope
glycoprotein 120 (gp120)-induced expression of pro-inflammatory
cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII)
and c-Jun N-terminal kinase (JNK) signaling pathways. J Biol. Chem.
Yuan, S., Shi, Y., Chen, J., Zhou, X., Li, G., Gelman, B.B.,
Lisinicchia, J.G., Carlton, S.M., Ferguson, M.R., Tan, A., Sarna, S.K.
and Tang, S.J. Gp120 in the pathogenesis of human HIV-associated pain. Ann Neurology. 75:837-850, 2014.
Link to PubMed Publications