« Back

Menon Laboratory

Welcome message
by Dr. Menon

GROUP Our Team
Rheanna Urrabaz-Garza, Luis Monsivais, Lavu Narmada, Lauren Richardson, Huaizhi Yin, Samantha Sheller-Miller, Ramkumar Menon, Sara Jacobs, Phyllis Orise, Talar Kechichian,
Chasey Omere, Dolores Quiroz

GROUP

At the recently concluded American Society for Reproductive Immunology, 39th Annual Meeting held n Grand Rapids MI (June 12 - 16, 2019). Dr. Menon was awarded the prestigious J. Christian Herr Award by the society for his last several decades' contributions and achievements in Reproductive Immunology.

GROUP
Graduation (Narmada Lavu) and Promotion (Lauren Richardson, Post-Doctoral fellow, Samantha Sheller-Miller, Post-Doctoral fellow I) Party

 

Fetal Membranes Biology Laboratory

The Menon laboratory is primarily interested in studying feto-maternal communications associated with maintenance of pregnancy and initiation of labor and delivery (parturition). The lab studies various aspects of fetal responses using fetal membrane (amniochorionic membrane/placental membrane ) as a model. Over 25 years, The Menon laboratory has studied changes in fetal membranes in response to various endogenous and exogenous factors and developed pathways and biomarkers associated with human parturition.

Dr Menon's laboratory receives NIH Grants

Dr Menon's laboratory has received two NIH grant awards in 2019.

  1. 1R21AI140249-01A1 
    This R21 award is for two years. This study will use engineer exosomes to contain HMGB1 and test their function in signaling parturition.
  2. R03HD098469
    This RO3 award is for two years. This study will examine the role of infection and inflammation in causing epithelial mesenchymal transitions in amnion epithelial cells.

Dr. Menon's lab receives a major contract from ILIAS Therapeutics, NY

Dr. Menon received a major contract from ILIAS Therapeutics in New York to study specific drug delivery using exosomes  to minimize the risk of preterm birth induced by infection. This 3 year contract is worth ~ $ 1.5 million.

Reproductive Biology - Exosome Laboratory

The Menon laboratory is studying the role of exosomes in pregnancy and parturition as a paracrine communication channels and its potential as a biomarker to predict adverse pregnancy outcome.

Exosomal communication and biomarker potential

Specific interests:

  1. Senescence of fetal membranes and regulation of senescence to reduce preterm birth
  2. Fetal membrane derived extracellular vesicles (exosomes) as feto-maternal paracrine signalers
  3. Microarchitecture of human fetal membranes, its function during pregnancy and mechanisms of membrane remodeling.
  4. Redefining the role of infectious agents and inflammatory mediators induced by infectious agents in fetal membranes during preterm birth.
  5. Contributions of environmental pollutants in preterm birth
  6. Image and exosome based biomarkers of preterm birth and preterm premature rupture of the membranes.

FANCY_GROUP