Faculty bio page2
Vanessa V. Sarathy, PhD

Vanessa V. Sarathy, PhDAssistant Professor

Department of Pathology
Director, Pathology Microscope Imaging Laboratory
Member, Institute for Human Infections and Immunity
Member, Sealy Institute for Vaccine Sciences
Lab: (409) 772-2547
Phone: (409) 772-2403
Email: vvsarath@utmb.edu

Vanessa V. Sarathy, PhD

The flaviviruses include mosquito-borne viruses of major public health importance, such as dengue and Zika viruses. Our research involves in silico, in vitro, and in vivo approaches to investigate the following

  • Pathogenesis of dengue hemorrhagic fever and dengue shock syndrome.
  • Mouse models of dengue disease to test candidate therapeutics and vaccines.
  • Antibody response to the flavivirus envelope glycoprotein.
  • Next generation sequencing characterization of flavivirus genomes.

 Dengue Virus Studies Poster (PDF)

AS Oklahoma State University, Oklahoma City, OK Industrial Lab Technology 2001
BS Univ of Central Oklahoma, Edmond, OK Biology 2003
PhD Univ of Texas Health Science Center Graduate School of Biomedical Sciences, Houston, TX Microbiology and Biochemistry 2010
Certificate University of Houston, Clear Lake, TX Advanced Business Management 2012
Postdoctoral Univ. of Texas Medical Branch, Galveston, TX Virology 2015
2013 Edward Jenner Poster Prize.  7th Vaccine and International Society for Vaccines Congress, Sitges, Barcelona, Spain.
2018-2021 American Society for Virology Program Committee/span>
2019 Convener of the Flaviviruses II Workshop,
38th Annual Meeting of American Society for Virology.
July 21, 2019.
2006 Gordon Research Conferences Carl Storm Underrepresented Minority Fellowship
2002-03 Psi Mu Chapter of Beta Beta Beta, National Biological Honor Society
2001-02 National Dean’s List Honoring America’s Outstanding College Students


2014/15 James W. McLaughlin Poster Travel Award. Institute for Human Infections & Immunity/McLaughlin Colloquium.  UTMB.
2013 Sealy Center for Vaccine Development Travel Award.  UTMB.
2013/14/15 Robert L. Harrison Award, Department of Pathology Annual Research Day. UTMB.
2012-14 T32 Postdoctoral Research Training in Emerging and Reemerging Infectious Diseases. UTMB.
2010 Postdoctoral Certificate Scholarship. UTMB.
2010 Molecular Basis of Infectious Disease Retreat.  Poster award. University of  Texas at Houston-Health Sciences Center.
2005/06/10 Graduate School of Biomedical Sciences Travel Award. UT Houston-HSC.

Dean’s/President’s Honor Roll, University of Central Oklahoma, Edmond, OK (UCO).

2002  College of Math and Science Scholarship. UCO.

President’s List of Distinguished Students. Oklahoma State University-Oklahoma City.

1999-01 Division of Arts and Sciences Scholarship. OSU-OKC.
1998-99 Student Ambassador Association Scholarship. OSU-OKC.
2019-present Director, Pathology Microscope Imaging Core Laboratory
2018-present Member, Sealy Institute for Vaccine Sciences, UTMB.
2016-present Member, Institute for Human Infectious and Immunity, UTMB.
2015-present Assistant Professor, Department of Pathology, School of Medicine, UTMB.
2010-2015 Postdoctoral Fellow, Dept. of Pathology, School of Medicine, UTMB.
2010-2012 Clinical Lab Sciences Teaching Assistant, School of Health Professions, UTMB.
2003-2010 Graduate Research Assistant – Univ of Texas Health Science Center, Houston, TX
1999-2003 Microbiology and Analytical Chemistry Technician.  OKLABS, Inc.  Oklahoma City, OK.
Scientific Societies
2014-Present American Society of Tropical Medicine and Hygiene
2012-Present American Society of Virology
2004-Present American Society for Microbiology
2002-2003 Beta Beta Beta National Biological Honor Society
Professional Development
2012 Advanced Business Management Certificate.  University of Houston, Clear Lake, TX. 
2011 Climbing to Success Faculty Development Conference.  Hispanic Center for Excellence. Moody Gardens Hotel, Galveston, TX.

Intramural NIAID Research Opportunities, National Institutes of Health, Bethesda, MD.

2002 Research Experience for Undergraduate Students, University of Houston, Houston, TX.
2000-01 Oklahoma Applied Research Support R&D Faculty and Student Intern Partnership Program. Oklahoma Center for the Advancement of Science and Technology.
  1. Li, G., Luo, H, Shan, C., Fontes-Garfias, C., Sarathy, V.V., Teleki, C., Winkelmann, E.R., Liang, Y., Sun, J., Bourne, N., Barrett, A.D., Shi, PY., Wang, T. An attenuated Zika virus nonstructural 4B protein mutant is a potent inducer of antiviral innate and adaptive immune responses in mice.  2019.  npj Vaccines.  Nov 28;4:48. PMID: 31815005.
  2. Li, L., Collins, N.D., Widen, S.G., Davis, E.H., Kaiser, J.A., White, M.M., Greenberg, M.B., Barrett, A.D.T., Bourne, N., Sarathy, V.V.  Attenuation of Zika virus by passage in Human HeLa cells.  2019.  Vaccines.  Aug 20;7(3). PMID: 31434319.
  3. Collins, N.D., Widen, S.G., Li, L., Swetnam D., Shi, PY., Tesh, R.B., Sarathy, V.V.  Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity.  2019.  Emerging Microbes and Infections. 8(1):1126-1138.  PMID:  31355708.
  4. Milligan, G.N. White, M., Zavala, D., Pyles, R.B., Sarathy, V.V., Barrett, A.D.T., and Bourne, N.  Spectrum of activity testing for therapeutics against all four dengue virus serotypes in AG129 mouse models:  Proof of concept studies with the adenosine nucleoside inhibitor NITD-008.  2018.  Antiviral Res.  Apr 14;154:104-109.  PMID:  29665374.
  5. Reece, L.M., Beasley, D.W., Milligan, G.N., Sarathy, V.V., Barrett, A.D.  2018.  Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development. Curr Opin Virol. Apr 8;29:72-78.  PMID:  29642053.
  6. Sarathy, V.V.,White, M., Li, L., Kaiser, J.A., Campbell, G.A., Milligan, G.N., Bourne, N. and Barrett, A.D.T.  2018.   Characterization of a murine model of non-lethal, symptomatic dengue virus infection.  Sci Rep. March 20;8(1):4900.  PMID:  29559699.
  7. Milligan, G.N., Sarathy, V.V., White, M., Greenberg, M.B., Campbell, Pyles, R.B., Barrett, A.D., Bourne, N. 2017. A lethal model of disseminated dengue virus type 1 infection in AG129 mice.  J. Gen Virol. Sep 27.  PMID:  28949904.
  8. Sarathy,V.V.,  Pitcher T.J., Gromowski,G.D., Roehrig, J.T., Barrett, A.D.T.  2017.  A DENV-2-type-specific monoclonal antibody binds to the DENV-complex-reactive antigenic site on envelope protein domain 3.  J. Gen Virol. 98(6):1299-1304.  PMID: 28631593. PMCID: PMC4298678.
  9. Sarathy, V.V., Milligan, G.N., Bourne, N., Barrett, A.D.  2015.  Mouse models of dengue virus infection for vaccine testing.  Vaccine, Oct 15.  PMID:  26478201.
  10. Pinto, A.K., Brien, J.D., Lam, C-Y.K., Johnson, S., Chiang, C., Hiscott, J., Sarathy, V.V., Barrett, A.D., Shresta, S., Diamond, M.S.  2015.  Defining new therapeutics using a more immunocompetent mouse model of antibody-enhanced Dengue virus infection. mBio, 6 (5), e01316-15.  PMID: 26374123. PMCID: PMC4600115.
  11. Sarathy, V.V., Infante, E., Li, L., Campbell, G.A., Wang, T., Paessler, S., Beatty, P.R., Harris, E., Milligan, G.N., Bourne, N. Barrett, A.D.  2015.  Characterization of lethal DENV-4 TVP-376 infection in mice lacking both IFN-alpha/beta and IFN-gamma receptors and comparison with the DENV-2 AG129 model.  J. Gen Virol, Jul 14.  PMID: 26296350. PMCID: PMC4635480.
  12. Milligan, G.N., Sarathy, V.V., Infante, E., Li, L., Campbell, G.A., Beatty, P.R., Harris, E., Barrett, A.D., Bourne, N.  2015.  A Dengue Virus Type 4 model of Disseminated Lethal Infection in AG129 mice.  PLoS One.  10 (5), e0125476.  PMID: 25938762. PMCID: PMC4418603.
  13. Sarathy, V.V., White, M., Li, L., Gorder, S.R., Pyles, R.B., Campbell, G.A., Milligan, G.N., Bourne, N., Barrett, A.D.  2015.  A lethal murine infection model for dengue virus 3 in AG129 mice deficient in type I and II interferon receptors leads to systemic disease.  J. Virol. 89 (2), 1254-66.  PMID: 25392217. PMCID: PMC4300670.
  14. Pitcher, T.J., Sarathy, V.V., Matsui, K., Gromowski, G.D., Huang, C-Y, Barrett, A.D.  2015.  Functional analysis of dengue virus (DENV) type 2 envelope protein domain 3 type-specific and DENV complex-reactive critical epitope residues. J. Gen Virol. 96, 288-93.  PMID: 25351518. PMCID: PMC4298678.
  15. Vazquez, V., Liang, X., Horndahl, J.K., Ganesh, V.K., Smeds, E., Foster, T.J., Hook, M.  2011.  Fibrinogen is a ligand for the Staphylococcus aureus microbial surface components recognizing adhesive matrix molecules (MSCRAMM) Bone sialoprotein-binding protein (Bbp).  J. Biol Chem, 286 (34), 29797-805.  PMID: 21642438.  PMCID: PMC3191021.

A complete list of my published work can be found at the following: