Grant L. Hughes, Ph.D.

Grant L. Hughes, Ph.D.

Assistant Professor, Department of Pathology

University of Texas Medical Branch

Office 2.138C Keiller
301 University Boulevard
Galveston, TX 77555-0609

Office (409) 772-9713

Labs (409) 747 2154
or (409) 747 0120
glhughes@utmb.edu

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Grant L. Hughes, Ph.D.

Professional Education

Degree Institution Field of Study Graduation Year
BSc

The University of Queensland

Science 1999
BSc Honours The University of Queensland Molecular Plant Science 2002
Ph.D. The University of Queensland Entomology 2008
Postdoctoral Fellow Johns Hopkins University Medical Entomology 2011
Research Associate Penn State University Medical Entomology 2014

Honors

2015 Rising Science and Technology Acquisition and Retention (STARs) Program award
2013 PSU Shared Technology Facilities Pilot Project Grant
2013 Keystone Symposia Scholarship
2013 Penn State University Travel Award
2012 Johns Hopkins Malaria Research Institute Postdoctoral Fellowship
2010 Jane Welsh Russell Fund Postdoctoral Scholarship

Research Interests

  1. Dissecting the tripartite interaction between mosquitoes, their microbes and the pathogens they transmit.
  2. Identifying and characterizing the molecular mechanisms facilitating bacterial symbiont – mosquito interactions.
  3. Understanding how adaptation to the mosquito host shapes symbiont genomes.
  4. Developing new genetic tools to manipulate insect vectors.
  5. Investigating novel microbial control approaches to reduce arthropod-borne disease.

Selected Publications

  1. Hughes GL, Dodson BL, Johnson RM, Murdock CC, Tsujimoto H, Suzuki Y, Patt AA, Cui L, Nossa CW, Barry RM, Sakamoto JM, Hornett EA, Rasgon JL. (2014) Native microbiome impedes vertical transmission of Wolbachia in Anopheles mosquitoes. Proceedings of the National Academy of Sciences USA. 111 (34): 12498-12503.
  2. Hughes GL, Rivero A, Rasgon JL (2014) Wolbachia can enhance Plasmodium infection in mosquitoes: Implications for malaria control? PLoS Pathogens. 10(9): e1004182.
  3. Ren X*, Hughes GL*, Niu G, Suzuki Y, Rasgon JL. (2014) Anopheles gambiae densovirus (AgDNV) has negligible affects on adult survival and transcriptome of its mosquito host. PeerJ. 2:e584. * Equal contribution.
  4. Dodson BL, Hughes GL, Paul O, Matacchiero AC, Kramer LD, Rasgon RL. (2014) Wolbachia enhances West Nile virus (WNV) infections in the mosquito Culex tarsalis. PLoS Neglected Tropical Diseases. 8(7):e2965.
  5. Suzuki Y, Nui G, Hughes GL, Rasgon JL. (2014) Densoviral vector-based gene over-expression system for the malaria mosquito, Anopheles gambiae. Scientific Reports. 4: 5127.
  6. Hughes GL, Samuels SK, Shaikh K, Rasgon JL, Vardo-Zalik AM (2014). Discrimination of the Plasmodium mexicanum vectors Lutzomyia stewarti and Lutzomyia vexator using a PCR-RFLP assay and Wolbachia infection. Journal of Vector Ecology. 39 (1): 224-227..
  7. Murdock CC, Blanford S, Hughes GL, Rasgon JL, Thomas MB (2014) Temperature alters malaria transmission blocking by Wolbachia.Scientific Reports. 4: 3932.
  8. Bourtzis K, Dobson SL, Xi Z, Rasgon JL, Calvitti M, Moreira LA, Bossin H, Moretti R, Baton LA, Hughes GL, Mavingui P, Gilles J. (2014) Harnessing mosquito-Wolbachia symbiosis for vector and disease control.Acta Tropica. 132:S150-160

  9. Hughes GL, Xue P, Vega-Rodriguez J, Rasgon, JL. (2012) Wolbachia strain wAlbB enhances infection by the rodent malaria parasite Plasmodium berghei in Anopheles gambiae mosquitoes. Applied and Environmental Microbiology. 78 (5): 1491-1495.

  10. Hughes GL*, Pike AD*, Xue P, Rasgon JL. (2012) Use of an ex vivo organ culture system to investigate the invasion of Wolbachia into Anopheles and other insect germlines. PLoS ONE. 7(4): e36277. * Equal contribution.

  11. Hughes GL, Koga R, Xue P, Fukatsu T, Rasgon JL. (2011) Wolbachia infections are virulent and inhibit the human malaria parasite Plasmodium falciparum in Anopheles gambiae. PLoS Pathogens. 7 (2) e1002043. (May 2011 issue Cover Article).
  12. Hughes GL, Ren X, Ramirez J, Sakamoto JM, Bailey JA, Jedlicka J.A, Rasgon JL. (2011) Wolbachia infections in Anopheles gambiae cells: transcriptomic characterization of a novel host-symbiont interaction. PLoS Pathogens. 7 (2) e1001296.
  13. Hughes GL, Allsopp PG, Brumbley SM, Woolfit M, McGraw EA, O’Neill SL (2011) Variable infection frequency and high diversity of multiple strains of Wolbachia pipientis in Perkinsiella planthoppers. Applied and Environmental Microbiology. 77 (6): 2165–2168.

  14. Hughes GL, Allsopp PG, Webb RI, Yamada, R, Iturbe-Ormaetxe I, Brumbley SM, O’Neill SL (2011) Identification of yeast associated with the planthopper, Perkinsiella saccharicida: potential applications for Fiji Leaf Gall control. Current Microbiology. 63 (4): 392-401.

  15. McMeniman CJ, Hughes GL, O’Neill SL (2011). A Wolbachia symbiont in Aedes aegypti disrupts mosquito egg development to a greater extent when mosquitoes feed on nonhuman versus human blood. Journal of Medical Entomology. 48: 76-84.
  16. Hughes GL, Allsopp PG, Brumbley SM, Johnson KN, O’Neill SL (2008) In vitro rearing of Perkinsiella saccharicida and the use of leaf segments to assay Fiji disease virus transmission. Phytopathology. 98: 810-814.
  17. Jones CM, Nagel L, Hughes GL, Cribb TH, Grutter AS (2007) Host specificity of two species of Gnathia (Isopoda) determined by DNA sequencing blood meals. International Journal for Parasitology. 37: 927-935.
  18. Book Chapter: Hughes GL, Rasgon JL (2012). Wolbachia infections in arthropod hosts. In Insect Pathology and Microbial Pest Control. 2nd Edition. (eds) Kaya HK, Vega FE. New York, Elsevier.

NIH Biosketch