Xue-jie Yu, M.D., Ph.D.

Xue-jie Yu, M.D., Ph.D.

Professor, Department of Pathology;
Center for Biodefence and Emerging Infectious Diseases; Seally Center for Vaccine Development

University of Texas Medical Branch
1.136D Keiller Building
301 University Boulevard
Galveston, TX 77555-0609

Office: (409) 747-1786
Fax: (409) 747-2455

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Xue-jie Yu, M.D., Ph.D.

Professional Education

Degree Institution Field of Study Graduation Year
M.D. Shandong Medical University, China Medicine 1983
Masters Chinese Academy for Preventive Medicine, China Preventive Medicine 1988
Ph.D. Universite D’Aix-Marceille II, France Cellular Biology & Microbiology 1993

Professional Affiliations

  • American Society for Rickettsiology
  • American Society for Microbiology
  • American Association for the Advancement of Science

Research Interests

My research interest is to understand the pathogenesis of obligate intracellular bacteria Rickettsia and Ehrlichia and host-pathogen interactions. My research on Rickettsia is to identify the virulence determinants of Rickettsia and to develop a vaccine for Rocky Mountain spotted fever and epidemic typhus. My research in Ehrlichia is to decipher the mechanisms of host immune evasion utilized by Ehrlichia, especially how Ehrlichia survives inside phagocytes and cause persistent infection in animals.

Selected Publications

  1. Yu XJ, Walker DH, Liu Y, and Zhang LH. Amino acid biosynthesis deficiency in bacteria associated with human and animal hosts. Infect Genet Evol, 9:514-7, 2009.
  2. Driskell LO, Yu XJ, Zhang L, Liu Y, Popov VL, Walker DH, and Wood DO. Directed mutagenesis of the Rickettsia prowazekii pld gene encoding phospholipase D. Infect and Immun, 77:3244-8, 2009.
  3. Zhang L, Liu Y, Ni D, Li Q, Yu Y, Yu XJ,Wan K, Li D, Liang G, Jiang X, Jing H, Run J, Luan M, Fu X, Zhang J Yang W, Wang Y, Dumler JS, Feng Z, Ren J, and Xu J. Nosocomial transmission of human granulocytic anaplasmosis in China. JAMA 300:2263 – 2270, 2008.
  4. Zhu, Y., A. Medina-Sanchez, D. Bouyer, D. H. Walker, and Yu XJ. Genotyping Rickettsia prowazekii isolates. Emerg. Infect. Dis. 14:1300-1302, 2008.
  5. Zhang JZ, Popov SL, Gao S, Walker DH, and Yu XJ. The developmental cycle of Ehrlichia chaffeensis in vertebrate cells. Cellular Microbiology. 9:610-8, 2007.
  6. Yu XJ, McBride JW, and Walker DH. Restriction and expansion of Ehrlichia strain diversity. Veterinary Parasitology. 143:337- 46, 2007.
  7. Zhang JZ, Hao JF, Walker DH, Yu XJ. A mutation inactivating the methyltransferase gene in avirulent Madrid E strain of Rickettsia prowazekii reverted to wild type in the virulent revertant strain Evir. Vaccine. 24: 2317-23, 2006.
  8. Zhang JZ, Winslow GM, Yu XJ. Expression of members of the 28-kDa major outer membrane protein family of Ehrlichia chaffeensis during persistent infection. Infect. Immun. 72: 4336-4346, 2004.
  9. McLeod MP, Qin X, McNeill TZ, Gioia J, Highlander, SK, Fox GE, Karpahty SE, Jiang H, Chao H, Yu XJ, Walker, DH, Weinstock GM. The complete genome of Rickettsia typhi and compararison with R. prowazekii and R. conorii. J. Bacteriol. 186:5842-5855, 2004.
  10. Zhang JZ, Sinha M, LuxonBA, and Yu XJ. Survival strategy of obligately intracellular Ehrlichia: novel modulation of immune response andhost cell cycles. Infect. Immun. 72:498-507, 2004.
  11. Long SW, Zhang XF, Zhang JZ, Ruble RP, Teel P, and Yu XJ: Evaluation of transovarial transmission and transmissibility of Ehrlichia chaffeensis (Rickettsiales: Anaplasmataceae) in Amblyomma americanum (Acari: Ixodidae). J. Med. Entomol. 40: 1000-1004, 2003.
  12. Long S W, Zhang XF, Qi H, Standaert S, Walker DH, Yu XJ: Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kDa protein gene family. Infect. Immun. 70:1824-1831, 2002.
  13. Yu XJ, Zhang XF, McBride JW, Zhang YL, and Walker DH:Phylogenetic relationships of Anaplasma marginale and Ehrlichia platys to other Ehrlichia determined by GroEL amino acid sequences. Int. J. Syst. Evol. Bacteriol. 51:1143-1146, 2001.
  14. Yu XJ, McBride JW, Zhang, XF, Walker DH. 2000. Characterization of the complete transcriptionally active Ehrlichia chaffeensis 28 kDa outer membrane protein multigene family. Gene. 248:59-68, 2000.
  15. Yu XJ, McBride JW, Diaz CM, and Walker DH. Molecular cloning and characterization of the 120- kDa protein gene of Ehrlichia canis and application of the recombinant 120-kDa protein for serodiagnosis of canine ehrlichiosis. J. Clin. Mcrobiol. 38:369-374, 2000.
  16. Popov VL, Yu XJ, and Walker DH: The120 kDa outer membrane protein of Ehrlichia chaffeensis: preferential expression on dense-core cells and gene expression in Escherichia coli associated with attachment and entry. Microbial. Pathog. 28:71-80, 2000.
  17. Yu XJ, Crocquet-Valdes PA, Cullman LC, Popov VL, and Walker DH.Comparison of Ehrlichia chaffeensis recombinant proteins for diagnosis of human monocytotropic ehrlichiosis. J. Clin. Microbiol. 37: 2568–2575, 1999.
  18. Yu XJ, McBride JW, Walker DH: Genetic diversity of the 28-kilodalton outer membrane protein of human isolates of Ehrlichia chaffeensis. J. Clin. Microbiol. 37:1137-1143, 1999.
  19. Yu XJ, Crocquet-Valdes PA, Cullman LC, Walker DH: Cloning and sequencing of the gene for a 120-kDa immunodominant surface protein of Ehrlichia chaffeensis. Gene. 184:149-154, 1997.
  20. Yu XJ, Brouqui P, Dumler JS, Raoult D: Detection of Ehrlichia chaffeensis in human tissue by using a species-specific monoclonal antibody. J. Clin. Microbiol. 31:3284-3288, 1993.

NIH Biosketch