The Research Histopathology Core (RHC)

Core LogoThe Research Histopathology Core (RHC) with laboratories in both Galveston National Laboratory and Basic Science Building provides analytical morphology related services to the research teams and educational programs at UTMB. The facility is equipped with the latest available instrumentation and operated by highly skilled personnel, who can assist with tissue preparation, immunohistochemistry, immunofluorescence, Insitu hybridization, including assay optimization, image analysis, digital photomicrography, and anatomical consultation. RHC provides an expanded service including coordinated histopathology support services or developing special protocols to fit your research needs for investigators engaging in research in emerging diseases. RHC looks forward to providing these services to fit your research needs and yielding high quality results.


HIstopathology Staff

L to R: Dr. Gustavo Valbuena (Director), Kerry Graves (Research Associate), Natalie Dobias (Histotechnologist) and Kenneth R. Escobar (Laboratory Manager)

Kenneth R. Escobar (Laboratory Manager) is an ASCP certified Histotechnologist with long term experience in clinical/diagnostic and research histopathology.

Natalie Dobias (Histotechnologist) has 9 years’ experience in clinical/ diagnostic and research histopathology.

Kerry Graves (Research Associate) has extensive expertise in Immunohistochemistry, having worked diagnostic and research laboratories at UTMB since 1978.

Dr. Gustavo Valbuena (Director) is a physician-scientist with training in Anatomical, Clinical, and Experimental Pathology. After obtaining his medical degree in 1996, he pursued a combined program at UTMB consisting of residency in Pathology and PhD in Experimental Pathology. Dr. Valbuena completed this combined program in 2003, and he has been a member of Research Pathology faculty since 2006.

Services Available

Services included:

  • Tissue processing and embedding
  • Special microtomy and cryotomy
  • Routine and special staining
  • Immunohistochemistry, manually and automated
  • Immunohistochemistry assay development
  • Insitu Hybridization
  • TUNEL staining (manual)
  • Two color immunohistochemistry
  • Immunofluorescence staining

Equipment available for users includes:

  • Laser capture microdissection system
  • Tissue arrayer
  • Image analysis software
  • Microtome and cryostat
  • Photomicroscope
  • Light and epifluorescent microscope
  • Dissecting microscope with photo image software
  • Cytocentrifuge for preparation of cell smears


Research Histopathology Core Laboratory: (409) 747-0735
GNL Histopathology Core Laboratory: 409-266-6684
Fax: (409) 747-0725

Kenneth Escobar:
Natalie Dobias:


The admixture of neoplastic spindle cells with extravasated red blood cells creates resemblance to Kaposi’s sarcoma. Used with permission from