Biostatistics and Data Management Resource 3 Core (BDM-RC3) The Pepper Center at UTMB
The OAIC Biostatistics and Data Management Resource Core 3 (BDM-RC3) is a new component of the Center. Previous training and services in biostatistics were embedded in the RCDC. The growing interest of our scholars and investigators in clinical trials, biomarker discovery, and research with large datasets has increased our need for biostatistical and data management support. The goal of the BDM-RC3 is to develop an infrastructure that leverages institutional biostatistical and bioinformatics resources to provide a broad set of advanced and innovative tools for OAIC research. Core personnel are highly qualified researchers who provide support with expertise in study design, data management, and statistical analysis of data from a wide range of research applications. Core faculty also have a strong record of developing statistical methods to address questions resulting from studies of observational and clinical interventions.
The Specific Aims of the LAC are to:
- Train OAIC faculty and RCDC scholars in biostatistics and data management to help them plan, conduct, and draw conclusions from their investigations in aging.
- Support and add value to funded projects related to the theme of the OAIC by actively participating in the design, monitoring, data management, and statistical analysis of studies on pathways of and interventions to improve physical function and recovery in older adults.
- Develop novel methods and tools for aging research. We will build on our expertise in machine learning, nonparametric and resampling methods, and survival analysis as approaches to addressing issues of pragmatic trials, clinical interventions, and comparative effectiveness research in aging.
- Enhance the OAIC current information systems infrastructure to assist in procurement, management, and processing of data collected from extant databases as well as new clinical study outcomes.
From its inception, the UTMB OAIC has had strong involvement from biostatisticians, epidemiologists, and other data scientists from the Office of Biostatistics (OBIOS), the UTMB Sealy Center on Aging (SCOA), and the Institute for Translational Sciences (ITS). The relationship between members of the new BDM Core and the RCDC will formalize the involvement of individual biostatistical investigators in OAIC research, ensuring access to all researchers of the biostatistical and data management resources they need to effectively conduct their investigations.
Data Management System for Outcomes Research
The Data Management System for Medical Research (DMSMED) provides support for database management and data analyses for research at UTMB. The DMSMED office is in the Sealy Center on Aging. The DMSMED enables (new) investigators who are without access to sophisticated computing capabilities and/or personnel to devise an efficient, integrated data management system that allows them to participate in large database research. In addition, the data on the server can be accessed through the UTMB computer network, which maintains data security. It is convenient and flexible for investigators and staff members to work on their projects. It has worked with many OAIC investigators and trainees and currently supports Dr. Jaramillo as an RCDC scholar. Personnel: Since the inception of DMSMED, Dr. Dong Zhang [email] has overseen the data management procedures for individual projects and coordinated interaction between the staff and investigators. He has a PhD in biostatistics, but now devotes most of his efforts to the management of complex and large databases. He has considerable expertise in statistical computing and data management. He formally instructs statistical computing courses, and mentors junior faculty and trainees on statistical issues. His other responsibilities include providing security for data server access and planning for new equipment purchases and upgrades to computer systems.
Office of Biostatistics (OBIOS)
The Office of Biostatistics provides statistical support services to all UTMB faculty, staff and students. The areas of expertise include design support, database design, management and data analysis. Design support services include power calculations, sample size determinations, and identification of appropriate methods to minimize experimental error. Database design services focus on the development of project specific systems for data acquisition, scheduling and modification. Data management services include development of data collection techniques/ instruments, data entry screens, and data editing and error checking programs. Data analysis services focus on the application of appropriate methods to allow valid statistical inferences. In addition, through collaboration between UTMB researchers and members of the office, OBIOS can provide developmental procedures that will produce improved methods and procedures to collect, manage, analyze and interpret biomedical data.
OBIOS is the point of contact for the computer package SAS® campus-wide and provides expert and technical support for the SAS® system, a statistical application with extensive data management capabilities. OBIOS maintains Query Advisor 7.0 and nTerim nQuery Advisor® - a software calculates sample size and power for various statistics methods, ArcGIS – a mapping and spatial analysis software, and TreeAge – a software to build graphical decision tree and conduct analyses. OBIOS maintains the United Health Group insurance claims data base (Clinformatics DataMart), which contains the medical and pharmacy claims for approximately 50 million enrollees for academic training and research purposes. This database offers numerous opportunities for collaboration between faculty and students. OBIOS provides support to the Institute for Translational Science through the Biostatistics, Epidemiology and Research Design (BERD) Key Resource. Dr. Yong Fang Kuo [email], the Co-Leader of the Biostatistics and Data Management Resource Core, is Director of the Office of Biostatistics.