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Metabolism and Biology Resource Core (MB-RC2) The Pepper Center at UTMB

The Metabolism and Biology Resource Core (MB-RC2) of the UTMB OAIC supports and promotes integrative and translational research on the metabolic and biological mechanisms underlying functional loss and recovery in older adults. The MB-RC2 also supports biological sample storage, tracking and handling for larger clinical trials. 

Leadership

Core Leader: Blake Rasmussen, PhD [web bio]
Co-Leader: Chris Fry, PhD [web bio]
Co-Leader: John Papaconstantinou, PhD [web bio]
Lab Manager: Ming-Qian Zhang [email]

The Specific Aims of the MB-RC2 are to:
  1. Provide the infrastructure for sample storage, analytical support and add value to funded translational research on sarcopenia, physical dysfunction and recovery requiring molecular, morphological, or tracer methodologies
  2. Leverage other institutional analytical core resources and simplify access for OAIC investigators
  3. Develop new translational methods to study the biological and metabolic mechanisms of sarcopenia, physical function and recovery in older adults

The MB-RC2 will promote integration of molecular, cellular and tracer methodologies within individual experiments in humans to discover the mechanisms that underlie specific pathophysiological responses in older adults. It will provide biorepository and shipping services for clinical trials. It will also stimulate reverse translation from clinical findings to the bench, which will allow us to refine our basic knowledge and perform pre-clinical testing of novel interventions for functional loss with aging.

Investigator Support
  • Biorepository
  • Stable isotope analyses to measure metabolism
  • Metabolic modeling
  • Cell signaling
  • Real time PCR
  • Cell morphology
  • High throughput hormone assays
  • High throughput cytokine assays
  • Proteomics
  • Gene microarrays
  • Train new investigators
  • Develop new methods
  • Cell culture
Pepper Center Laboratories
Supported Projects

Title

Principal Investigator

Agency

Grant
Number

Period

MBRC Support

Effects of amino acids on regional lipid metabolism

Elizabet Børsheim, MD, PhD
(UAMS)

NIA

R01 AG033761

2010-2015

Stable isotope, Modeling, Rep.

Nutrient regulation of amino acid transporters in aging human skeletal muscle

Micah Drummond, PhD

NIA

K01AG038556

2011-2015

Stable isotope, Rep. Modeling

Non-invasive assessment of skeletal muscle loss in cancer patients

William J. Durham, PhD (site)

NIAMS

R44AR054993

2007-2015

Stable isotope, Rep.

Preserving muscle mass and function in bedridden older adults

Douglas Paddon-Jones, PhD

NINR

R01 NR012973

2012-2016

Stable isotope, Rep, Signaling, Morph.

Whey, protein, aging and physical inactivity

Douglas Paddon-Jones, PhD

DRI

1146a

2013-2016

Stable isotope, Rep. Signaling,

Distributed protein intake, whey protein and aging

Douglas Paddon-Jones, PhD

DRI

1146b

2013-2016

Stable isotope, Rep. Signaling

Nutritional and contractile regulation of muscle growth

Blake B. Rasmussen, PhD

NIAMS

R01 AR049877

2008-2014

Stable isotope, Rep. PCR, Signaling

A randomized, controlled double blind acute study: effects of protein blends on muscle protein synthesis and breakdown in aging

Blake B. Rasmussen, PhD

DuPont Nutrition & Health

2012-2014

Stable isotope, Rep. PCR, Signaling, Respirometry

Nutrition and anabolic interventions in cancer cachexia

Melinda Sheffield-Moore, PhD

NCI

R01 CA127971

2008-2014

Stable isotope, PCR, Signaling

Viagra administration and muscle growth and fatigue in older humans

Melinda Sheffield-Moore, PhD

Moody Fdn

2012-2015

Stable isotope, PCR, Signaling

Effect of brown adipose tissue activation on insulin sensitivity in humans

Labros Sidossis, PhD

ADA

1-14-TS-35

2014-2016

Stable isotope, Rep. Respirometry

Testosterone and leucine supplementation as gender specific countermeasures against musculoskeletal loss

Randall J. Urban, MD

NASA

NNX10AP86G

2010-2014

Stable isotope

Continuous versus cycling long-term testosterone

Randall J. Urban, MD

Moody Fdn

2012-2015

Stable isotope, PCR, Signaling

Effects of post-exercise whey peptide on muscle mTOR Signaling & protein synthesis in young & older adults

Elena Volpi, MD, PhD

MegMilk

2013-2015

Stable isotope, PCR, Signaling

ASPirin in reducing the effects on the elderly

Elena Volpi, MD, PhD (site)

NIA

U01 AG029824

2011-2017

Repository

Whey protein & exercise to accelerate recovery after acute hospitalization in previously independent older adults

Elena Volpi, MD, PhD

DRI

1229

2014-2016

Repository

Nutrition & exercise to improve protein metabolism & prevent sarcopenia in aging

Elena Volpi, MD, PhD

NIA

R01 AG030070

2008-2015

Stable isotope, PCR, Rep, Morph, Signal.


Site managed by UTMB Sealy Center on Aging • Last updated July 2017

301 University Blvd. Galveston, TX 77555-0177 | p 409.747.0008 | f 409.772.8931
The Claude D. Pepper Older Americans Independence Center Award #P30-AG024832 is funded by
the National Institute on Aging (NIA), part of the United States Department of Health and Human Services.