Mark Bowden, PhD
Department of Physical Therapy
Medical University of South Carolina
Phone: (843) 792-5036
A. Behrman, PhD, PT
Therapeutic applications to improve walking function after neurological injury and the mechanisms of how improved walking is attained
- 1991 Duke University Psychology BS
- 1995 Duke University Physical Therapy MS
- 2009 University of Florida Rehabilitation Science PhD
Grant #: N/A (Bowden) 11/1/16-10/31/17 HealthSouth Corporation S.C.O.P.E. Systematic Collection of Objective, Progressive Exercise Goal: The purpose of this study is to determine the efficacy of an intensity-based, standardized approach to inpatient physical therapy rehabilitation as compared to usual care. We will investigate the effects of the intensity-based program on functional outcomes at discharge from inpatient rehabilitation and on participation, quality of life, falls efficacy, falls frequency, stroke-related secondary health conditions, and re-admissions at 90 days after stroke. Role: PI
Grant# NIH 1P20GM109040-01(Bowden) 6/2/2014-3/31/2019 National Institute of Health Excitatory and Inhibitory rTMS as Mechanistic Contributors to Walking Recovery Goal: The purpose of this proposal is to address systematically the gaps in the understanding of rTMS for the lower extremity. This project involves multidisciplinary research linking rTMS with state-of-the-art neurophysiological assessment, neuromuscular/motor control assessment, and assessment of the neuromechanical contributors to impaired walking. Role: PI of sub-project in NIH P20 GM109040, "South Carolina Research Center for Recovery from Stroke" SA Kautz (Principal Investigator)
Grant#: N0787-W (Bowden) 04/01/2013-03/31/2018 Department of Veterans Affairs Rehabilitation Research & Development Augmentation of Locomotor Adaptation Post-Stroke (Bowden) Goal: The purpose of this project is to establish the optimal configuration of electrodes to excite neural circuits involved in post-stroke locomotion, identify effective strategies for training a specific locomotor adaptation, and improve adaptations via adjunctive non-invasive brain stimulation. Role: PI
Completed (past 3 years)
Grant#: SCIRF 10-003 (Bowden) 12/1/2010-11/30/2013 South Carolina Spinal Cord Injury Research Fund Propulsive Training in Incomplete Spinal Cord Injury Goal: The overall purposes of this proposal are to 1) assist in the development of an infrastructure necessary to adequately assess walking performance and underlying impairments of those with iSCI; and 2) provide a platform by which laboratory findings may be translated to clinical research interventions. Role: PI
Grant # 12 IRG 9430057 (Kautz) 01/01/2012-12/31/2013 American Heart Association Do spinal and cortical tDCS suggest distinct and synergistic neuromechanical mechanisms for post-stroke walking recovery? Goal: The purpose of this project is to examine whether single sessions of a task-specific physical intervention strategy combined with tDCS can improve rehabilitation outcomes by facilitating increased and more appropriate motor output of the paretic leg motoneuron pools when stimulating the cortex and/or the lumbrosacral spinal cord. Role: Co-I
Publications (past 5 years)
Aaron SE, Hong I, Bowden MG, Gregory CM, Embry AE, and Velozo CA. Use of the Rasch Measurement Model to Investigate Measurement Properties for the Dynamic Gait Index in Chronic Stroke. Edorium Journal of Disability and Rehabilitation. In Press.
Hunnicutt J, Aaron S, Embry AE, Cence B, Morgan P, Bowden MG, and Gregory CM. The Effects of POWER Training in Young and Older Adults Poststroke. Stroke Research and Treatment. Volume 2016, Article ID 7316250, http://dx.doi.org/10.1155/2016/7316250 PMCID: PMC4967472
Vistamehr A, Kautz SA, Bowden MG, Neptune RR. Correlations between Measures of Dynamic Balance in Individuals with Post-stroke Hemiparesis. J Biomech. 2016 Feb 8;49(3):396-400. doi: 10.1016/j.jbiomech.2015.12.047. Epub 2016 Jan 8.
Balasubramanian CK, Chih-Ying L, Bowden MG, Duncan PW, Kautz SA, Velozo CA. Dimensionality and item-difficulty hierarchy of the lower-extremity Fugl-Meyer assessment in individuals with sub-acute and chronic stroke. Arch Phys Med Rehabil. 2016 Apr;97(4): 582-9.
Charalambous CC, Bowden MG, Adkins DL. Motor Cortex and Motor Cortical Interhemispheric Communication in Walking After Stroke: The Roles of Transcranial Magnetic Stimulation and Animal Models in Our Current and Future Understanding. Neurorehabilitation and Neural Repair. 2016 Jan:30(1): 94-102.
DiPiro ND, Holthaus KD, Morgan PJ, Embry AE, Perry LA, Bowden MG, Gregory CM. Lower extremity strength is correlated with walking function after incomplete SCI. Topics in SCI Rehabilitation. 2015;21(2):133–139. PMCID: PMC4568094
Gregory CM, Embry A, Perry LA, Bowden MG. Quantifying human movement across the continuum of care: from lab to clinic to community. J Neuroscience Methods. 2014;231:18-21.
Dobkin B, Nadeau S, Behrman AL, Wu S, Rose D, Bowden MG, Studenski S, Lu X, Duncan PW. Baseline prediction of responders for interventions of the Locomotor Experience Applied Post Stroke trial. JRRD. 2014;51(1):39-50.
Charalambous CC, Bonilha HS, Kautz SA, Gregory CM, and Bowden MG. Rehabilitating Walking Speed Post- Stroke with Treadmill-based Interventions: A Systematic Review of Randomized Controlled Trials. Neurorehabilitation and Neural Repair. 2013;27(8):709-721. PMCID: PMC4478607
Behrman AL, Bowden MG, Rose DK. Clinical trials in Neurorehabilitation. Handbook Clin Neurol. 2013;110: 61-6.
Routson RL, Clark DJ, Bowden MG, Kautz SA, Neptune RR. Module quality and walking performance pre and post locomotor rehabilitation in adults post-stroke. Gait & Posture. 2013;38:511–517. PMCID: PMC3687005
Bowden MG, Behrman AL, Neptune RR, Gregory CM, Kautz SA. Locomotor rehabilitation of individuals with chronic stroke: difference between responders and non-responders. Arch Phys Med Rehabil. 2013;94:856-62.
Bowden MG, Woodbury ML, Duncan PW. Promoting neuroplasticity and recovery after stroke: future directions for rehabilitation clinical trials. Current Opinion in Neurology. 2013;26(1):37-42.
Feng W, Bowden MG, Kautz SA. Transcranial direct current stimulation: a potential tool to enhance post-stroke recovery. Topics in Stroke Rehabilitation. 2013;20(1):68-77.
Hall AL, Bowden MG, Kautz SA, Neptune RR. Biomechanical variables related to walking performance 6- months following post-stroke rehabilitation. Clinical Biomechanics. 2012:27(10):1017-22. PMCID: PMC3501552
Bowden MG, Embry AE, Perry LC, Duncan PW. Rehabilitation of walking after stroke. Current Treatment Options in Neurology. 2012;14(6):521-30.
Bowden MG, Behrman AL, Woodbury ML, Gregory CM, Velozo CA, Kautz SA. Advancing measurement of locomotor rehabilitation outcomes to optimize interventions and differentiate between recovery versus compensation. J Neurol Phys Ther. 2012 Mar;36(1):38-44.
Bowden MG, Embry AE, Gregory CM. Physical therapy adjuvants to promote optimization of walking recovery post stroke. Stroke Research and Treatment. Volume 2011 (2011), Epub 2011 Oct 12. PMCID: PMC3195278
Kautz SA, Bowden MG, Clark DJ, Neptune RR. Comparison of motor control deficits during treadmill and overground walking post-stroke. Neurorehabilitation and Neural Repair. 2011;25(8):756-764. PMCID: PMC4434587
Complete List of Published Work in MyBibliography