Investigating skeletal muscle damage, exercise in patients with muscular dystrophy, and the relationship between muscle pathology and functional mobility in people with neuromuscular disease.
- 1996 Brigham Young University, Exercise Science, BS
- 1998 Washington University, Physical Therapy, MS
- 2007 Washington University, Movement Science, PhD
Current Research Funding
R21 AR064949 (Lott) 09/19/2014- 06/30/2018 NIAMS. The goal of this project is to assess the safety and feasibility of a home based mild to moderate-intensity strengthening exercise program in boys with Duchenne muscular dystrophy.
(Lott) 09/01/2016- 08/31/2018 Myotonic Dystrophy Foundation/Wyck Foundation. The aim of this study is to investigate the development of magnetic resonance imaging as en endpoint in patients with myotonic dystrophy type 1 (DM1) and its relationship to functional measures used in clinical trials.
R01 AR056973 (Vandenborne) 04/01/2009-08/31/2020 NIAMS. The overall objective of this study is to validate the potential of noninvasive magnetic resonance imaging (MRI) and spectroscopy (MRS) to monitor disease progression and to serve as a surrogate outcome measure for clinical trials in Duchenne muscular dystrophy (DMD).
U54 AR052646 (Walter) 08/01/2015- 07/31/2020 NIAMS. This Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (MDCRC)’s primary objectives are to facilitate the attainment of clinically useful pharmacological means of inhibiting fibrosis and to identify the best existing pharmacological inhibitors of fibrosis, as well as drive the development of new classes of inhibitors.
CAT-1004-201 (Vandenborne) 06/01/2015 – 06/30/2018. Catabasis Pharmaceuticals. This study is a Phase ½ study of CAT-1004 in Pediatric Patients with Duchenne Muscular Dystrophy (DMD).
Willcocks RJ, Triplett WT, Lott DJ, Forbes SC, Batra A, Sweeney HL, Mendell JR, Vandenborne K, Walter GA. Leg Muscle MRI in identical twin boys with Duchenne muscular dystrophy. Muscle Nerve. 2018; In Press.
Barnard AM, Willcocks RJ, Finanger EL, Daniels MJ, Triplett WT, Rooney WD, Lott DJ, Forbes SC, Wang DJ, Senesac CR, Harrington AT, Finkel RS, Russman BS, Byrne BJ, Tennekoon GI, Walter GA, Sweeney HL, Vandenborne K. Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy. PloS one. 2018;13(3):e0194283.
Chen YW, Gregory C, Ye F, Harafuji N, Lott D, Lai SH, Mathur S, Scarborough M, Gibbs P, Bagiland C, Vandenborne K. Molecular signatures of differential responses to exercise trainings during rehabilitation. Biomed Genet Genom. 2017;2(1).
Nichols C, Jain MS, Meilleur KG, Wu T, Collins J, Waite MR, Dastgir J, Salman A, Donkervoort S, Duong T, Keller K, Leach ME, Lott DJ, Mcguire MN, Nelson L, Rutkowski A, Vuillerot C, Bönnemann CG, Lehky TJ. Electrical impedance myography in individuals with collagen 6 and laminin α2 congenital muscular dystrophy: a cross sectional and 2 year analysis. Muscle Nerve. 2017 Feb 22. [Epub ahead of print]
Willcocks RJ, Triplett WT, Forbes SC, Arora H, Senesac CR, Lott DJ, Nicholson TR, Rooney WD, Walter GA, Vandenborne K. Magnetic resonance imaging of the proximal upper extremity musculature in boys with Duchenne muscular dystrophy. J Neurol. 2017 264(1), 64-71.
Willcocks RJ, Rooney WD, Triplett WT, Forbes SC, Lott DJ, Senesac CR, Daniels MJ, Wang DJ, Harrington AT, Tennekoon GI, Russman BS, Finanger EL, Byrne BJ, Finkel RS, Walter GA, Sweeney HL, Vandenborne K. Multicenter Prospective Longitudinal Study of Magnetic Resonance Biomarkers in a Large Duchenne Muscular Dystrophy Cohort. Annals of Neurology. 2016 Apr;79(4):535-47.
Vohra RS, Lott D, Mathur S, Senesac C, Deol J, Germain S, Bendixen R, Forbes SC, Sweeney HL, Walter GA, Vandenborne K. Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements. PLoS One. 2015 Jun 23;10(6):e0128915. eCollection 2015.
Senesac CR, Lott DJ, Forbes SC, Mathur S, Arpan I, Senesac ES, Walter GA, Vandenborne K. Longitudinal Evaluation of Muscle Composition Using Magnetic Resonance in 4 Boys with Duchenne Muscular Dystrophy: Case Series. Phys Ther. 2015 Jan 15. PMID: 25592189
Forbes SC, Willcocks RJ, Triplett WT, Rooney WD, Lott DJ, Wang DJ, Pollaro J, Senesac CR, Daniels MJ, Finkel RS, Russman BS, Byrne BJ, Finanger EL, Tennekoon GI, Walter GA, Sweeney HL, Vandenborne K. Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study. PLoS One. 2014 Sep 9;9(9):e106435. eCollection 2014.
Lott DJ, Forbes SC, Mathur S, Germain SA, Senesac CR, Sweeney HL, Walter GA, Vandenborne KA. Assessment of Intramuscular Lipid and Metabolites of the Lower Leg using Magnetic Resonance Spectroscopy in Boys with Duchenne Muscular Dystrophy. Neuromuscular Disorders. 2014 Jul;24(7):574-82.
Complete List of Published Work in MyBibliography