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Scholars


photo of Donovan Lott, PhD, PT

Donovan Lott, PhD, PT

Research Assistant Professor

Department of Physical Therapy
University of Florida

Contact

Phone: (352) 273-6085
Email: djlottpt@phhp.ufl.edu

Lead Mentor

K. Vandenborne, PhD, PT

Research Areas

Investigating skeletal muscle damage, exercise training in neuromuscular disease, and muscle pathology and its relationship to functional mobility in patients with muscular dystrophy.

Education
  • 1996 Brigham Young University, Exercise Science, BS
  • 1998 Washington University, Physical Therapy, MS
  • 2007 Washington University, Movement Science, PhD

Research Funding

Current
Myotonic Dystrophy Foundation grant (Lott) 2016-1017 Development of Magnetic Resonance Imaging as an Endpoint in Myotonic Dystrophy Type 1 Goal: The goal of this study is to develop MRI as an endpoint to be used in future clinical trails for patients with Myotonic Dystrophy type 1. Role: PI

R21 AR064949- 01A1 (Lott) 2014-2017 (including NCE) Development of a Strength Training Protocol in Duchenne Muscular Dystrophy Goal: The goal of this study is to examine the safety and feasibility of a mild-moderate strengthening program in boys with Duchenne muscular dystrophy. Role: PI

ISIS598769-CS2 (Thornton) 2014-2016 A Phase 1/2a Blinded, Placebo-Controlled Study to Assess the Safety, Tolerability, and Dose-range Finding of Multiple Ascending Doses of ISIS 598769 Administered Subcutaneously to Adult Patients with Myotonic Dystrophy Type 1 The goal of this clinical trial is to assess the safety of administration of a new drug in patients with Myotonic Dystrophy Type 1. Role: Sub-Investigator & Clinical Evaluator

CAT-1004-201 Catabasis Pharmaceuticals (Vandenborne) 2015-2016 A Phase ½ study of CAT-1004 in Pediatric Patients with Duchenne Muscular Dystrophy Goal: The goal of this study is to assess the safety of administration of a new drug in patients with Duchenne muscular dystrophy. Role: Clinical Evaluator & Functional Evaluator Trainer

R01 AR056973 (Vandenborne) 2010-2020 Magnetic Resonance Imaging and Biomarkers in Muscular Dystrophy Goal: The goal of this study is to develop the use of magnetic resonance imaging and spectroscopy to be used as biomarkers in future clinical trials for patients with Duchenne muscular dystrophy. Role: Co-Investigator

U54AR052646 (Walter) 2010-2020 Failed Regeneration in the Muscular Dystrophies: Inflammation, Fibrosis, and Fat The goal of this study is to develop novel means of assessing skeletal and cardiac muscle via magnetic resonance imaging in people with muscular dystrophy. Role: Co-Investigator

Completed
USAMRMC Contract W81XH-11-1-0454 (Lott) 2012-2016 Muscle Injury Prevention & Rehabilitation in Military Personnel Goal: The goal of this study was to develop a clinical paradigm for assessing muscle injury and to explore the efficacy of a pre-rehabilitation program in reducing exercise induced muscle injury. Role: PI

Muscular Dystrophy Association grant (Thornton) 2013-2016 A Multicenter Observational Study to Assess the Variability of Molecular Biomarkers and Clinical Measures in Patients With Myotonic Dystrophy Type 1 Goal: The goal of this Myotonic Dystrophy Research Network study was to test the feasibility and determine the test-retest reliability of using RNA splice events as biomarkers of DM1 severity in multicenter studies. Role: Sub-Investigator & Clinical Evaluator

Publications (last 5 years)

Willcocks RJ, Rooney WD, Triplett WT, Forbes SC, Lott DJ, Senesac CR, Daniels MJ, Wang DJ, Harrington AT, Tennekoon GI, Russman BS, Finanger EL, Byrne BJ, Finkel RS, Walter GA, Sweeney HL, Vandenborne K. Multicenter Prospective Longitudinal Study of Magnetic Resonance Biomarkers in a Large Duchenne Muscular Dystrophy Cohort. Annals of Neurology, 2016 Apr;79(4):535-47. PMCID: PMC4955760

Vohra RS, Lott D, Mathur S, Senesac C, Deol J, Germain S, Bendixen R, Forbes SC, Sweeney HL, Walter GA, Vandenborne K. Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements. PLoS One. 2015 Jun 23;10(6):e0128915. PMCID: PMC4477876

Senesac CR, Lott DJ, Forbes SC, Mathur S, Arpan I, Senesac ES, Walter GA, Vandenborne K. Longitudinal Evaluation of Muscle Composition Using Magnetic Resonance in 4 Boys with Duchenne Muscular Dystrophy: Case Series. Phys Ther. 2015 Jan 15. [Epub ahead of print] PMCID: PMC4498145

Forbes SC, Willcocks RJ, Triplett WT, Rooney WD, Lott DJ, Wang DJ, Pollaro J, Senesac CR, Daniels MJ, Finkel RS, Russman BS, Byrne BJ, Finanger EL, Tennekoon GI, Walter GA, Sweeney HL, Vandenborne K. Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study. PLoS One. 2014 Sep 9;9(9):e106435. PMCID: PMC4159278

Lott DJ, Forbes SC, Mathur S, Germain SA, Senesac CR, Sweeney HL, Walter GA, Vandenborne KA. Assessment of Intramuscular Lipid and Metabolites of the Lower Leg using Magnetic Resonance Spectroscopy in Boys with Duchenne Muscular Dystrophy. Neuromuscular Disorders. 2014 Jul;24(7):574- 82. PMCID: PMC4142654

Arpan I, Willcocks RJ, Forbes SC, Finkel RS, Lott DJ, Rooney WD, Triplett WT, Senesac CR, Daniels MJ, Byrne BJ, Finanger EL, Russman BS, Wang DJ, Tennekoon GI, Walter GA, Sweeney HL, Vandenborne K. Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS. Neurology. 2014 Sep 9;83(11):974-80. PMCID: PMC4162304

Bendixen RM, Lott DJ, Senesac C, Mathur S, Vandenborne K. Participation in daily life activities and its relationship to strength and functional measures in boys with Duchenne muscular dystrophy. Disabil Rehabil. 2014;36(22):1918-23. PMCID: PMC3358238

Willcocks RJ, Arpan IA, Forbes SC, Lott DJ, Senesac CR, Senesac E, Deol J, Triplett WT, Baligand C, Daniels MJ, Sweeney HL, Walter GA, Vandenborne K. Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression. Neuromuscul Disord. 2014 May;24(5):393-401. PMCID: PMC4277599

Manini TM, Buford TW, Lott DJ, Vandenborne K, Daniels MJ, Knaggs JD, Patel H, Pahor M, Perri MG, Anton SD. Effect of dietary restriction and exercise on lower extremity tissue compartments in obese, older women: a pilot study. J Gerontol A Biol Sci Med Sci. 2014 Jan;69(1):101-8. PMCID: PMC4158399

Forbes SC, Walter GA, Rooney WD, Wang DJ, DeVos S, Pollaro J, Triplett W, Lott DJ, Willcocks RJ, Senesac C, Daniels MJ, Byrne BJ, Russman B, Finkel RS, Meyer JS, Sweeney HL, Vandenborne K. Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy. Radiology. 2013 Oct;269(1):198-207. PMCID: PMC3781359

Triplett WT, Baligand C, Forbes SC, Willcocks RJ, Lott DJ, Devos S, Pollaro J, Rooney WD, Sweeney HL, Bönnemann CG, Wang DJ, Vandenborne K, Walter GA. Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle. Magn Reson Med. 2013 Sep 4. PMCID: PMC4307808

Arpan I, Forbes SC, Lott DJ, Senesac CR, Daniels MJ, Triplett WT, Deol JK, Sweeney HL, Walter GA, Vandenborne K. T2 mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year- old boys with Duchenne muscular dystrophy. NMR Biomed. 2013 Mar;26(3):320-8. PMCID: PMC3573223.

Forbes SC, Lott DJ, Finkel RS, Senesac C, Byrne BJ, Sweeney HL, Walter GA, Vandenborne K. MRI/MRS evaluation of a female carrier of Duchenne muscular dystrophy: a case study. 2012, Neuromuscular Disorders. 22 Suppl 2:S111-21. PMCID: PMC3458312

Bendixen RM, Senesac C, Lott DJ, Vandenborne K. Participation and Quality of Life in children with Duchenne muscular dystrophy using the International Classification of Functioning, Disability, and Health. 2012, Health and Quality of Life Outcomes. 10:43. PMCID: PMC3358238

Marzetti E, Lees HA, Manini TM, Buford TW, Aranda JM, Calvani R, Capuani G, Marsiske M, Lott DJ, Vandenborne K, Bernabei R, Pahor M, Leeuwenburgh C, Wohlgemuth SE. Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study. 2012, PLoS ONE. 7(2):e32829. PMCID: PMC3289676

Buford TW, Lott DJ, Marzetti E, Wohlgemuth SE, Vandenborne K, Pahor M, Leeuwenburgh C, Manini TM. Agerelated differences in lower extremity tissue compartments and associations with physical function in older adults. 2012, Exp Gerentol. 47(1):38-44. PMCID: PMC3245356

Bishop MD, Horn ME, Lott DJ, Arpan I, George SZ. Relationship between muscle damage and pain intensity in exercise induced low back pain. 2011, Spine J. 11(12):135-42. PMCID: PMC3437659

Complete List of Published Work in MyBibliography

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USC: University of Southern California logo
UTMB: University of Texas Medical Branch logo