Scholars


photo of Dr. Smith

Barbara Smith, PT, PhD

Research Assistant Professor

Departments of Physical Therapy and Pediatrics
University of Florida

Contact
Phone: (352) 294-4058
Email: bksmith@phhp.ufl.edu

Lead Mentor
B. Byrne, PhD

Research Areas

Respiratory strength and functional outcomes in patients with respiratory muscle weakness or mechanical ventilation. Use of exercise and regenerative rehabilitation to facilitate motor recovery of ventilation.

Education

  • 1992 Grove City College, Grove City, PA Molecular Biology BS
  • 1994 University of Pittsburgh, Pittsburgh, PA Physical Therapy MPT
  • 1998 University of Florida, Gainesville, FL Physical Therapy MHS
  • 2010 University of Florida, Gainesville, FL Rehabilitation Sciences PhD
  • 2011 University of Florida, Gainseville, FL Physiological Sciences Post-Doc

Current Research Funding

R01 AR072328 (Martin) 6/1/2017 – 5/31/2021 National Institute of Arthritis and Musculoskeletal and Skin Diseases Effect of Intermittent Hemidiaphragm Stimulation during Surgery on Mitochondrial Function, Single Fiber Contractile Force and Catabolic Pathways in Humans. This project will evaluate changes in diaphragm fiber force production, oxidative capacity and catabolism following intraoperative diaphragm stimulation.

R21HD090752 (Smith) 9/1/2016 – 1/31/2019 National Institute of Child Health and Human Development (NICHD) Diaphragm Pacing and Rehabilitation in Pompe Disease. This research study evaluates respiratory plasticity and recovery of independent breathing in patients with Pompe disease who have undergone clinical diaphragmatic pacing. 

NCT02704273 (Smith: Site PI) 8/1/2016 – 12/31/2019 Audentes Therapeutics INCEPTUS: A Clinical Assessment Study in X-Linked Myotubular Myopathy Subjects . This is a prospective, non-interventional clinical assessment study to evaluate XLMTM subjects aged 3 and younger.

NCT02453512 (Smith) 11/01/2015 – 7/31/2018 Audentes Therapeutics, Inc. Respiratory Strength and Function in Untreated X-linked Myotubular Myopathy. This study is a longitudinal study evaluating the severity and progression of respiratory muscle function in patients with X-Linked Myotubular Myopathy (XLMTM) aged 0-14 years.

NCT02354664 (Smith) 07/01/2015 – 6/30/2018 BioMarin Pharmaceutical Foundation Dynamic Respiratory Muscle Function in Late-Onset Pompe Disease (NCT02354664). This study compares traditional tests of respiratory strength and endurance to magnetic resonance imaging as markers of dynamic respiratory motor function, in adults with late-onset Pompe disease.

NIH 2U54AR052646 (Sweeney) 08/01/2015 – 07/31/2018 Failed Regeneration in the Muscular Dystrophies: Inflammation, Fibrosis, and Fat. This project is organized around the concept that limiting fibrosis in the muscular dystrophies will help extend the period of successful regeneration.

NIH/NHLBI U01HL121842 (Byrne) 10/01/2015 – 11/30/2018 Phase II Study of AAV9-GAA Gene Transfer in Pompe Disease. The study investigates advancement of clinical research of adeno-associated vector (AAV) expressing human acid alpha-glucosidase (GAA) approaches to treat respiratory failure caused by Pompe disease.

Recent Publications

Smith BK, Carter N, Arteaga A, Dinh AC, Martin AD.Acute and six-month outcomes in recipients of lung transplant following lower extremity strength training. Journal of Acute Care Physical Therapy. Manuscript In Press.

Smith BK and Falk DJ. Mechanical Ventilation for Duchenne Muscular Dystrophy: Sinner or Saint? Muscle & Nerve. 2018; 57(3): 353-5.

Corti M, Liberati C, Smith BK, Lawson LA, Tuna IS, Conlon TJ, Coleman KE, Islam S, Herzog RW, Fuller DD, Collins SW, Byrne BJ. Safety of Intradiaphragmatic Delivery of Adeno-Associated Virus-Mediated Alpha-Glucosidase (rAAV1-CMG-hGAA) Gene Therapy in Children Affected by Pompe Disease. Human Gene Therapy Clinical Development. 2017; 298(2): 216-24. PMCID: PMC5733674.

Smith BK, Martin AD, Lawson LA, Vernot V, Marcus J, Islam S, Shafi N, Corti M, Collins SW, Byrne BJ. Inspiratory muscle conditioning exercise and diaphragm gene therapy in Pompe disease: clinical evidence of respiratory plasticity. Experimental Neurology. 2017; 287 (Pt 2): 216-24. PMCID: 5178134.

Complete List of Published Work in MyBibliography

UF: University of Florida logo
USC: University of Southern California logo
UTMB: University of Texas Medical Branch logo
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