The Sealy Center on Aging (SCoA) currently supports 22 clinical trials and is proactively looking for industry trial opportunities. This has been the result of a deliberate effort to increase clinical trial capacity and improve the processes that facilitate clinical trial initiation, regulatory support, and coordination.
The Center increased the pool of study coordinators and restructured the Clinical Research Resource Core and Volunteer Registry to better support investigators in their regulatory needs and subject recruitment.
SCoA's participation in two large clinical trials funded by the NIH and PCORI include:
- the ASPREE trial of aspirin to improve functional and cognitive outcomes in older adults
- the STRIDE Study on fall prevention in older adults living in the community using a pragmatic approach.
- Watch a video about the STRIDE Study, presented by Elena Volpi, MD, PhD
The work on our electronic health record (EHR) system conducted as part of the UT System grant has positioned the Center at the forefront for use of our EHR for clinical trials, leading to our inclusion as a clinical site in the STRIDE Study.
|IRB Number||Project Title||Open Recruitment|
|#09-203||Skeletal Muscle Microvascular Perfusion and the Obesity Paradox in CHF||CHF Only|
|#12-153||The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue||Healthy Older Adults Only|
|#13-038||Feasibility Study of Post-hospitalization Interventions to Improve Physical Function in Older Adults||At UTMB Hospital|
|#13-0285||STEP AND GO: Study of Technology-based Exercise Promotion||Healthy Subject Only|
|#14-0113||ASPREE Cancer Endpoints Study||ASPREE patients Only|
|#14-0142||Fall risk reduction in the elderly through the Physical Therapy management of incontinence: a pilot study||At PT Clinics|
|#14-0527||Prevalence of Malnutrition and/or Sarcopenia on Hospital Admission||At UTMB Hospital|
|#14-0527||Self-monitoring activity: a randomized trial of game-oriented applications (SMARTGOAL)||Healthy Subjects Only|
|#15-0098||Feasibility of a Post-Hospitalization PT Intervention in Patients with Pneumonia||At PT Clinics|
|#15-0128||Economic and Humanistic Impact of Low Peak Inspiratory Flow Rate (PIFR) In COPD Patients: An Observational Analysis||At UTMB Hospitalized Patients Only|
|#15-0226||Nutrient Sensing and Signaling in Aging Muscle||Healthy Subjects Only|
|IRB#-||Brigham and Women’s Hospital- STRIDE- Strategies to Reduce Injuries and Develop confidence in Elders||At Primary Care Clinics|
|IRB Number||Project Title||Closed Recruitment|
|#08-085||Nutrition & Exercise to Improve Protein Metabolism & Prevent Sarcopenia in Aging||data analysis and manuscript writing|
|#09-150||A Non-Invasive Assessment of Skeletal Muscle Loss in Cancer Patients||data analysis and manuscript writing||#09-197||Effects of Amino Acids on Regional Lipid Metabolism||data analysis and manuscript writing||#09-200||Pilot Study to Discover Predictors of Muscle Loss with Aging||data analysis and manuscript writing||#09-213||Role of Skeletal Muscle Nitric Oxide Production in Age-Related Fatigue and Fatigability||data analysis and manuscript writing||#10-207||Nutrition and Anabolic Interventions in Cancer Cachexia - Head/Neck Cancer||data analysis and manuscript writing||#11-091||Pilot Study of Losartan and N-acetylcysteine as Inhibitors of Muscle Oxidative Stress in Elderly||data analysis and manuscript writing|
|#11-301||ASPREE: ASPirin in Reducing Events in the Elderly||study visits ongoing for several years|
|#13-071||IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial||data analysis and manuscript writing|
|#13-0390||Open Acute Study: Effects of Post-Exercise Whey Peptide on Muscle mTOR Signaling and Protein Synthesis in Healthy Young and Older Adults||data analysis and manuscript writing|
|#14-0333||Effect of Specific Amino Acids on Human Muscle Protein Synthesis||data analysis and manuscript writing|
The Volunteer Registry
Senior volunteers (age 55 and over) are invited to join the Volunteer Registry. The Registry is a list of volunteers interested in contributing to research studies on the health and well-being of older persons. Aging research participants also have a chance to learn more about their own health.
Pepper Center Studies
Senior volunteers (age 60 and over) are invited to participate in research on muscle function, fitness, and health and well-being of older persons. Muscle strength will be studied in terms of the effect of exercise, drugs, hormones and nutrition.