Discovery at the interface of computation, biology, and translation

Partner with SIDD to accelerate therapeutic discovery.

The Sealy Institute for Drug Discovery (SIDD) collaborates with academic labs, biotech startups, and pharmaceutical partners to rapidly translate scientific ideas into therapeutic programs. Our teams combine computation, experimental biology, and translational expertise to move discoveries from concept to candidate.

• Industry and biotech drug discovery collaborations
• AI-guided molecular design and computational pipelines
• Translational programs spanning biologics, peptides, and small molecules
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Partnership-Ready Discovery

Bring SIDD into the room early.

SIDD is built to help partners move from promising science to actionable discovery strategy quickly — before time, capital, and experiments are spent in the wrong direction.

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For Biotech & Pharma

Collaborate with SIDD investigators to de-risk early discovery programs, explore new therapeutic modalities, and prioritize candidates with rigorous computational and experimental insight.

For Academic Investigators

Partner with SIDD to convert disease biology, molecular mechanisms, and promising targets into structured discovery programs with translational momentum.

For Strategic Partners

Engage SIDD around platform-building opportunities, sponsored research, technology development, and long-term discovery alliances.

SIDD research team gathered outside the research building Laboratory researcher performing bench work Research presentation in a SIDD facility

Research Focus

Integrated discovery platforms for modern therapeutics

SIDD combines deep computational expertise with collaborative biomedical research to support discovery, optimization, and translation across diverse therapeutic modalities.

Computational Drug Discovery

Advanced molecular modeling, docking, simulation, and AI-guided design workflows accelerate therapeutic discovery from concept to candidate.

Peptide & Biomolecular Engineering

Design and evaluation of peptides, biomaterials, and targeted molecular systems for translational biomedical applications.

Translational Research

Bridging high-impact computation with experimental collaboration to move promising discoveries toward real-world outcomes.

Investigators

Meet the scientists shaping SIDD research programs

SIDD brings together investigators spanning translational biology, therapeutic antibodies, oligonucleotide medicines, neuroimmune biomaterials, neurodegeneration, medicinal chemistry, and AI-guided molecular discovery.

Sanja Sever, PhD

Institute Director

Sanja Sever, PhD

Director of the Sealy Institute for Drug Discovery · Vice President of Drug Discovery

Translational drug discovery focused on dynamin biology, cytoskeleton dynamics, endocytosis, kidney disease, and neurodegenerative disease.

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Xuping Xie, PhD

Principal Investigator

Xuping Xie, PhD

Associate Professor · Scientific Director at SIDD

Antiviral and flavivirus-focused drug discovery, including mechanistic studies and therapeutic development in microbiology and immunology.

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Hugues Fausther-Bovendo, PhD

Principal Investigator

Hugues Fausther-Bovendo, PhD

Assistant Professor

Therapeutic antibody discovery and bioengineering, including monoclonal antibodies against respiratory and emerging viral pathogens.

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Young-Hwan Jung, PhD

Principal Investigator

Young-Hwan Jung, PhD

Assistant Professor

Small-molecule drug design, targeted protein degradation, epigenetic modulation, and translational programs in pain, cancer, infectious, and neurodegenerative disease.

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Daniel O’Reilly, PhD

Principal Investigator

Daniel O’Reilly, PhD

Assistant Professor

Oligonucleotide therapeutics for rare and ultra-rare disease, including chemistry, delivery, efficacy, and tissue specificity in CNS and heart targets.

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Kyle Koss, PhD

Principal Investigator

Kyle Koss, PhD

Assistant Professor

Peptide and biomaterial engineering at the neuroimmune interface, with emphasis on microglia, glial scar biology, implantable devices, and biosensors.

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Claudia Marino, PhD

Principal Investigator

Claudia Marino, PhD

Assistant Professor

Biophysical and biomolecular approaches to neurodegeneration, Alzheimer’s disease resilience mechanisms, and disease-modifying therapeutic development.

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Lukasz Jaremko, PhD

Principal Investigator

Lukasz Jaremko, PhD

Associate Professor · MD3 Lab

AI-augmented structure and dynamics-guided drug discovery, cancer mechanisms, spectroscopy, metabolomics, and therapeutics for difficult targets.

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Why Partner With SIDD

Scientific depth, translational focus, and discovery infrastructure in one institute.

SIDD helps partners clarify targets, evaluate molecular strategies, and prioritize next steps using a coordinated mix of computational modeling, experimental insight, and therapeutic-domain expertise.

Discovery partnerships for academic, biotech, and pharmaceutical teams
Computational triage before costly experimental investment
Integrated therapeutic platforms across antibodies, oligonucleotides, peptides, and small molecules
Translational strategy from mechanism to candidate selection

About SIDD

Computation as a catalyst for biomedical innovation

The Sealy Institute for Drug Discovery provides an environment where interdisciplinary teams can combine chemistry, biology, computation, and translational insight to accelerate the path from molecular concept to therapeutic opportunity.

Opportunities

Research partnerships, training, and collaborative growth

Whether supporting students, collaborating with investigators, or engaging translational partners, SIDD is structured to amplify scientific momentum and enable ambitious discovery programs.

SIDD researcher presenting scientific imaging in a gallery hallway Visitors touring a SIDD research space

Get in Touch

Interested in collaborating with SIDD?

Reach out to discuss research collaborations, translational initiatives, student opportunities, or institutional partnerships.

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