Current Studies

Last updated June 12, 2018

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Studies currently being conducted by the SIVS Clinical Trials Program (click on the ClinicalTrials.gov Identifier (NCT number) for more information
Recruiting

Current Studies - Recruiting

NCT03537508: Immunogenicity and Safety Study of an Investigational Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers

Sponsor: Sanofi Pasteur Principal Investigator: Richard Rupp, MD

NCT03486834: Double-Blind, Randomized, Placebo-Controlled Phase 2b, Multi-center Study to Evaluate the Safety, Tolerability, Efficacy and Immunogenicity of a 2-Dose and a 3- Dose Regimen of V160 (Cytomegalovirus [CMV] Vaccine) in Healthy Seronegative Women, 16 to 35 Years of Age

Sponsor: Merck Sharp & Dohme Corp Principal Investigator: Richard Rupp, MD
NCT03480763: A Phase 3, Multicenter, Randomized, Double-Blind, Active Comparator-Controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by Administration of PNEUMOVAX™23 One Year Later in Healthy Adults 50 Years of Age or Older (PNEU-PATH)

Sponsor: Merck Sharp & Dohme Corp Principal Investigator: Richard Rupp, MD

NCT03090191: A phase III, placebo-controlled, randomized, observer-blinded study to evaluate the efficacy,  and tolerability of a Clostridium difficile vaccine in adults 50 years of age and older

Sponsor: Pfizer Inc.    Principal Investigator: Richard Rupp, MD
Active, Not Recruiting

Current Studies - Active, Not Recruiting

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)    Principal Investigator: Richard Rupp, MD

NCT03207750: A phase IIIA, randomized, single-blind, multi-centric study to evaluate the immunogenicity, reactogenicity and safety of three doses of Pediarix®, Hiberix®and Prevenar 13®when co-administered with two doses of the PCV-free liquid formulation of GSK Biologicals' oral live attenuated HRV vaccine as compared to the currently licensed lyophilized formulation of the HRV vaccine in healthy infants 6-12 weeks of age

 Sponsor: GlaxoSmithKline      Principal Investigator: Richard Rupp, MD
NCT02987972: A Phase II, Double-Blind, Randomized, Multicenter Trial to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Compared to Prevnar 13™ in Healthy Infants

Sponsor: Merck Sharp & Dohme Corp    

Principal Investigator: Richard Rupp, MD, Pediatric Clinic, Galveston Island East
Principal Investigator: Mark Wolffarth, MD, Pediatric Clinic, League City (Bay Colony)

NCT02624947: A Phase 3, Randomized, Observer-Blind, Placebo-Controlled, Group-Sequential Study to Determine the Immunogenicity and Safety of a Respiratory Syncytial Virus (RSV) F Nanoparticle Vaccine With Aluminum in Healthy Third-trimester Pregnant Women; and Safety and Efficacy of Maternally Transferred Antibodies in Preventing RSV Disease in Their Infants 

Sponsor: Novavax     Principal Investigator: George Saade, D

NCT00000000: A Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Live-Attenuated Tetravalent Dengue Vaccine (V181) in Flavivirus-Naïve and Flavivirus-Experienced Healthy Adults

Sponsor: Merck Sharp & Dohme Corp  Principal Investigator: Richard Rupp, MD
NCT03512288: A Phase 2, Randomized, Double-blind Trial To Evaluate The Safety And Immunogenicity Of A Multivalent Pneumococcal Conjugate Vaccine In Healthy Infants

Sponsor: Pfizer Inc.       Principal Investigator: Richard Rupp, MD

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