research in my laboratory focuses on cell-mediated immunity to viruses.
We utilize a genital herpes simplex virus infection of mice as a model
of epithelial and neuronal viral infection. Using vaccination with
attenuated strains of HSV-2 as a paradigm for an effective herpes virus
vaccine, we are investigating the activation and expression of B and T
cell effector function in the genital tract and peripheral nervous
system against HSV-2 infection. Additionally, we are examining the
differentiation and maintenance of antigen-specific memory CD4+ and CD8+ T
cells within the genital mucosa and sensory ganglia. We are also
interested in interactions between viral pathogens and the innate immune
system and how these interactions shape the adaptive immune response.
For these studies we utilize single-cycle flavivirus particles to
examine the role of specific pathogen pattern receptors and innate
immune signal pathways in the development of innate and adaptive immune
responses to West Nile Virus.
Search PubMed for Dr. Milligan's publications.