Global web ALERT button

Michael R. Holbrook, PhD (adjunct)

After completing his PhD in Molecular and Cellular Biology at the University of Massachusetts, Dr. Holbrook moved to Dr. Alan Barrett’s laboratory at UTMB. At UTMB, his work had several foci that included from virus sequencing, development of antiviral, structural virology and viral pathogenesis. Following post-doctoral training, he moved to a faculty position at the University of New Mexico but was recruited back to UTMB to become director of the new BSL-4 facilities. In addition to faculty responsibilities, Dr. Holbrook also took on the role of Director of Emerging and High Risk Pathogens Core in the Galveston National Laboratory which included the new BSL-4 facilities. Dr. Holbrook developed projects studying tick-borne flaviviruses, yellow fever virus, Rift Valley fever virus, Nipah virus and Ebola virus. These projects included structural studies, drug development and evaluating mechanisms of viral pathogenesis with a focus on innate immunity. Dr. Holbrook is the former director of the Shope BSL-4 laboratory and the emerging and high-risk pathogens core at the Galveston National Laboratory at UTMB and was an associate professor in the Department of Pathology. In 2009 he moved to a position at the National Institute of Allergy and Infectious Diseases (NIAID) Integrated Research Facility (IRF) in Frederick, MD.

Dr. Holbrook is a senior scientist at the IRF and also serves as the high-containment supervisor with responsibility for overseeing all research activities within the Biosafety Level (BSL)l-4 facility. Dr. Holbrook’s work has included the development of diagnostic agents as well as the testing of a number of different vaccines and chemotherapeutic agents against BSL-3 and BSL-4 viruses, in addition to extensive research experience in viral pathogenesis, viral immunology, viral protein expression and characterization, viral structure, and molecular virology. Dr. Holbrook has served as principal investigator, co-investigator, and consultant on a number of National Institutes of Health-supported grants and contracts.

Search PubMed for Dr. Holbrook's publications.