Dr. Peterson's research activities have been in the areas of toxin-mediated
bacterial diseases, including cholera, anthrax, and salmonellosis. The majority
of the lab's current research is focused on the evaluation of drugs, monoclonal
antibodies, and vaccines that block the pathogenesis of anthrax. Screening of
potential therapeutics is performed in tissue culture assays with the B.
anthracis toxins before they are selected for further evaluation in small animal
models of inhalation anthrax. Through collaboration, Dr. Peterson is
investigating the molecular mechanism(s) by which the anthrax lethal factor
kills macrophage cells designing and synthesizing more effective inhibitors of
anthrax lethal factor and edema factor, as well as enterotoxins that stimulate
intestinal adenylate cyclase. Ultimately, this research will advance the
treatment or prophylaxis against inhalation anthrax and selected diarrheal
diseases. Dr. Peterson also serves as the Director of the Aerobiology Division of the GNL. Search PubMed for Dr. Peterson's publications.