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Welcome to the SOCC

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The Synthetic Organic Chemistry Core (SOCC) at UTMB was established in 1998 to study and develop new methods and protocols for the synthesis of modified nucleosides representing known DNA damage, and for conversion of these nucleosides into phosphoramidites that can be conveniently and site-specifically incorporated into synthetic DNA sequences. The SOCC also develops methods for incorporating lesion sites into oligonucleotides via post-synthesis methods and protocols for purifying and analyzing these defined products. The synthetic organic services provided have also been adapted and expanded over the past 18 years to accommodate the growing need for synthesis and purification of other small molecules and bioconjugates that are of interest to biomedical and environmental health researchers at UTMB and elsewhere. This area of synthesis continues to grow rapidly with expansion of the Integrative Health Sciences Facility Core's Exposure Assessment and Biomarker Development Facility and its focus on assay development for monitoring exposure and disease.

The SOCC fulfills two main purposes:

To provide a cost-effective, on-campus chemical synthesis facility with expertise in the synthesis of defined chemical DNA lesions either unavailable elsewhere or prohibitively expensive commercially, as well as other unavailable organic molecules, bioconjugates and biomarkers for biological, medical and environmental health research.

To reduce costs for this service by sharing these resources and their maintenance campus-wide among several research groups who use the facility. Maintenance of the SOCC's equipment is taken care of daily by trained and qualified personnel at minimal costs to researchers through charge-back fees for services.

The SOCC program for achieving these goals utilizes known literature methods and develops new methods and protocols when necessary. The SOCC specifically has expertise in the synthesis of modified nucleosides representing known site-specific DNA damage and also development of methods and protocols for purifying and analyzing these defined products.

The SOCC is located in 1200 ft² laboratory space on the second floor (Rm. 2.130) of Maurice Ewing Hall on the Northside of the UTMB campus on Harborside Drive. The SOCC lab comprises four separate areas: an instrument room, chemistry lab, DNA synthesis lab and a glassware cleaning / storage area. The SOCC is a fully stocked functional organic synthesis laboratory with equipment necessary for most any type of synthesis project. Key equipment include:

  • Ace Glass 2L photochemical reactor
  • Aldrich Flash Chromatography columns 100g, 1Kg and 3Kg media capacities
  • Two Applied Biosystems Expedite Model 8909 DNA synthesizers
  • Shimadzu Prominence UFLC Model LC-20AB / CBM-20A with Model SPD-M20A PDA detector
  • Waters Breeze 2 Analytical HPLC Model 1525 pump with Model 2998 PDA detector
  • Beckman System 32 Karat Analytical HPLC Model 125 pump with Model 168 PDA detector
  • Beckman Preparative HPLC Model 126P pump with Model 166P variable detector
  • Two Buchi Model R-210 2L rotary evaporators with B-491 heating bath and V-850 controller
  • LabConco FreeZone 4.5L lyophilizer
  • LabConc Centrivap concentrator with cold trap
  • Perkin Elmer Lambda XLS UV spectrophotometer
  • Mettler Toledo C20 coulometric KF titrator
  • Kugelrhor bulb to bulb distillation apparatus
  • Optical Activity AA05 Polarimeter
  • Spectrolinker XL-1000 UV crosslinker
  • Analtech Cyclograph centrifugal TLC system
  • Parr 125mL 3000psi @ 350oC high pressure reactor

Core Director and Members

Richard P. Hodge, PhD
Director, Synthetic Organic Chemistry Service Core, Scientist, Sealy Center for Environmental Health & Medicine

Linda C. Hackfeld, MS
Member, Synthetic Organic Chemistry Service Core, Research Associate III, Sealy Center for Environmental Health & Medicine

Omar Guerra, BS
Member, Synthetic Organic Chemistry Service Core, Research Associate I, Sealy Center for Environmental Health & Medicine

SOCC Forms and Pricing

For UTMB Campus researchers please use the Internal Service Request form below:

For all other researchers please use the External Service Request form below:

For further questions contact:
Richard P. Hodge, PhD
Director, Synthetic Organic Chemistry Core 
Email: rphodge@utmb.edu
Tel: 409-747-6870
Fax: 409-772-5650
Mail Route 1110