Shriners Hospitals for Children Training Grant

Shriners ExteriorOur training program goal is to provide an educational environment to young physicians and/or scientists interested in academic research in the areas of burns and trauma. This program is an integrated two-year research experience which offers the individual trainee highly-structured research training in fundamental aspects of molecular biology, physiology, biochemistry, metabolism, immunology and cell biology as they pertain to the pathophysiologic state post burn.

The program includes basic or bench research, animal research and human or clinical studies in which the concepts of interpreting basic information from the laboratory and applying it to clinical problems and clinical research are taught. Clinical and basic science investigators are focusing their efforts to address problems pertinent to improving survival and the quality of life of burned children. Research trainees at our institutions, supported by NIH training grants over the last 19 years have made a significant difference in the understanding of burn care. During the past decade, pediatric mortality has decreased from 32% to 17% for burns over 60% total body surface area. This decrease in mortality is due to advancements in resuscitation, control of the metabolic response to trauma, control of infection and early total coverage of burn wounds, which are partly due to our NIH post doctoral fellows' research efforts. From their research efforts, we have been able to decrease the length of hospital stay by half. As mentors, we continue to direct our trainees' interest in the areas of cardiopulmonary pathophysiology, responses to thermal injury at the molecular level, metabolism, immunology, infection, wound healing and the integrated and long term outcomes of burned children. We firmly believe that research training at UTMB/SHCG in basic and clinical areas have advanced burn care.