Research Studies

MCNG Programmatic Vision

Mitchell Center Publications for 2019-2020:

  1. McGrath EL, Schlagal CR, Cortez I, Dunn TJ, Gao J, Fox RG, Stutz SJ, Kuo YF, Hommel JD, Dineley KT, Cunningham KA, Kaphalia BS, Wu P. Chronic poly-drug administration damages adult mouse brain neural stem cells. Brain Res. 2019 Nov15;1723:146425. doi: 10.1016/j.brainres.2019.146425. Epub 2019 Aug 29. PubMed PMID: 31473223.
  2. Montalbano M, McAllen S, Sengupta U, Puangmalai N, Bhatt N, Ellsworth A, Kayed R. Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration. Aging Cell. 2019 Sep 18:e13035. doi: 10.1111/acel.13035. [Epub ahead of print] PubMed PMID: 31532069.
  3. Limon A, Delbruck E, Yassine A, Pandya D, Myers RM, Barchas JD, Lee F, Schatzberg, Watson SJ, Akil H, Bunney WE, Vawter MP, Sequeira A. Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABA(A) receptors. Transl Psychiatry. 2019 Sep 5;9(1):218. doi: 10.1038/s41398-019-0551-1. PubMed PMID: 31488811; PubMed Central PMCID: PMC6728327.
  4. Gorgun MF, Zhuo M, Dineley KT, Englander EW. Elevated Neuroglobin Lessens Neuroinflammation and Alleviates Neurobehavioral Deficits Induced by Acute Inhalation of Combustion Smoke in the Mouse. Neurochem Res. 2019 Sep;44(9):2170-2181. doi: 10.1007/s11064-019-02856-8. Epub 2019 Aug 16. PubMed PMID: 31420834.
  5. Limon A, Hagopian G, Reyes-Ruiz JM, Miledi R. Tonic Calcium-Activated Chloride Current Sustained by ATP Release and Highly Desensitizing Human P2X1 Receptors. Neuroscience. 2019 Jul 23. pii: S0306-4522(19)30509-3. doi: 10.1016/j.neuroscience.2019.07.025. [Epub ahead of print] PubMed PMID: 31349005.
  6. Dasari AKR, Kayed R, Wi S, Lim KH. Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations. Biochemistry. 2019 Jun 25;58(25):2814-2821. doi: 10.1021/acs.biochem.9b00215. Epub 2019 Jun 7. PubMed PMID: 31132261; PubMed Central PMCID: PMC6754703.
  7. Marino C, Krishnan B, Cappello F, Taglialatela G. Hsp60 Protects against Amyloid β Oligomer Synaptic Toxicity via Modification of Toxic Oligomer Conformation. ACS Chem Neurosci. 2019 Jun 19;10(6):2858-2867. doi: 10.1021/acschemneuro.9b00086. Epub 2019 May 24. PubMed PMID: 31091411.
  8. Micci MA, Krishnan B, Bishop E, Zhang WR, Guptarak J, Grant A, Zolochevska O, Tumurbaatar B, Franklin W, Marino C, Widen SG, Luthra A, Kernie SG, Taglialatela G. Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes. Mol Neurodegener. 2019 Jun 14;14(1):25. doi: 10.1186/s13024-019-0322-8. PubMed PMID: 31200742; PubMed Central PMCID: PMC6570890.
  9. Franklin W, Krishnan B, Taglialatela G. Chronic synaptic insulin resistance after traumatic brain injury abolishes insulin protection from amyloid beta and tau oligomer-induced synaptic dysfunction. Sci Rep. 2019 Jun 3;9(1):8228. doi: 10.1038/s41598-019-44635-z. PubMed PMID: 31160730; PubMed Central PMCID: PMC6546708.
  10. Sequeira A, Shen K, Gottlieb A, Limon A. Human brain transcriptome analysis finds region- and subject-specific expression signatures of GABA(A)R subunits. Commun Biol. 2019 May 1;2:153. doi: 10.1038/s42003-019-0413-7. eCollection 2019. PubMed PMID: 31069263; PubMed Central PMCID: PMC6494906.
  11. Comerota MM, Tumurbaatar B, Krishnan B, Kayed R, Taglialatela G. Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies. Mol Neurobiol. 2019 May;56(5):3341-3355. doi: 10.1007/s12035-018-1248-9. Epub 2018 Aug 17. PubMed PMID: 30120733; PubMed Central PMCID: PMC6476871.
  12. Lallai V, Grimes N, Fowler JP, Sequeira PA, Cartagena P, Limon A, Coutts M, Monuki ES, Bunney W, Demuro A, Fowler CD. Nicotine Acts on Cholinergic Signaling Mechanisms to Directly Modulate Choroid Plexus Function. eNeuro. 2019 Apr 23;6(2). pii: ENEURO.0051-19.2019. doi: 10.1523/ENEURO.0051-19.2019. eCollection 2019 Mar-Apr. PubMed PMID: 31119189; PubMed Central PMCID: PMC6529591.
  13. Gao R, Chakraborty A, Geater C, Pradhan S, Gordon KL, Snowden J, Yuan S, Dickey AS, Choudhary S, Ashizawa T, Ellerby LM, La Spada AR, Thompson LM, Hazra TK, Sarkar PS. Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription. Elife. 2019 Apr 17;8. pii: e42988. doi: 10.7554/eLife.42988. PubMed PMID: 30994454; PubMed Central PMCID: PMC6529219.
  14. Cortez I, Denner L, Dineley KT. Divergent Mechanisms for PPARγ Agonism in Ameliorating Aging-Related Versus Cranial Irradiation-Induced Context Discrimination Deficits. Front Aging Neurosci. 2019 Mar 14;11:38. doi: 10.3389/fnagi.2019.00038. eCollection 2019. PubMed PMID: 30930764; PubMed Central PMCID: PMC6427093.
  15. Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L. Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway. Int J Mol Sci. 2019 Mar 6;20(5). pii: E1144. doi: 10.3390/ijms20051144. PubMed PMID: 30845718; PubMed Central PMCID: PMC6429086.
  16. Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Am J Physiol Endocrinol Metab. 2019 Jan 1;316(1):E106-E120. doi: 10.1152/ajpendo.00279.2018. Epub 2018 Nov 13. Erratum in: Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E345. PubMed PMID: 30422705; PubMed Central PMCID: PMC6417684.
  17. Peng H, Guo T, Chen Z, Zhang H, Cai S, Yang M, Chen P, Guan C, Fang X. Hypermethylation of mitochondrial transcription factor A induced by cigarette smoke is associated with chronic obstructive pulmonary disease. Exp Lung Res. 2019 Apr - May;45(3-4):101-111. doi: 10.1080/01902148.2018.1556748. Epub 2019 Jun 14. PubMed PMID: 31198067.
  18. Sengupta U, Kayed R. Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau. Neuropsychopharmacology. 2019 Jan;44(1):222-223. doi: 10.1038/s41386-018-0204-8. PubMed PMID: 30206420; PubMed Central PMCID: PMC6235868.
  19. Navani A, Manchikanti L, Albers SL, Latchaw RE, Sanapati J, Kaye AD, Atluri S, Jordan S, Gupta A, Cedeno D, Vallejo A, Fellows B, Knezevic NN, Pappolla M, Diwan S, Trescot AM, Soin A, Kaye AM, Aydin SM, Calodney AK, Candido KD, Bakshi S, Benyamin RM, Vallejo R, Watanabe A, Beall D, Stitik TP, Foye PM, Helander EM, Hirsch JA. Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician. 2019 Jan;22(1S):S1-S74. PubMed PMID: 30717500.
  20. Bourne KZ, Natarajan C, Perez CXM, Tumurbaatar B, Taglialatela G, Krishnan B. Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer's disease mouse model promotes synaptic resilience. Sci Rep. 2019 Dec 4;9(1):18342. doi: 10.1038/s41598-019-54974-6.
  21. Zolochevska O and Taglialatela G. Selected microRNAs Increase Synaptic Resilience to the Damaging Binding of the Alzheimer's Disease Amyloid Beta Oligomers. Mol Neurobiol 2020. PMID 31997075
  22. Bittar  A, Bhatt N, Kayed R. Advances and Considerations in AD Tau-Targeted Immunotherapy. Neurobiol Dis 2020, 134, 104707.PMID: 31841678  PMCID: PMC6980703  DOI: 10.1016/j.nbd.2019.104707
  23. Derry  PJ, Hegde ML, Jackson GR, Kayed R, Tour JM, Tsai A, Kent TA. Revisiting the Intersection of Amyloid, Pathologically Modified Tau and Iron in Alzheimer's Disease From a Ferroptosis Perspective. Prog Neurobiol, 2020, 184, 101716 . PMID: 31604111  DOI: 10.1016/j.pneurobio.2019.101716.