Neonatal acne, a response to maternal androgens, first appears at 2 to 4 weeks of age, lasting until age 4 to 6 months. The lesions are primarily on the face, chest, and back in a similar distribution as adolescent acne. The lesions seen are also similar to adolescent acne including open and closed comedones, papules, pustules, and occasionally nodules. All of the lesions are in similar stage. Persistence of neonatal acne beyond 12 months of age should arouse suspicion of endocrine abnormalities.