1. Cooper University Hospital (PDF)
2. Heart of England Sepsis Screening Tool (PDF)
3. Guysborough Antigonish Strait Health Authority
4. Iowa Health System, ED Adult Sepsis Screening Tool (PDF)
5. Novato Community Hospital (PDF)
6. Pamona Valley Hospital (PDF)
7. Presbyterian Intercommunity Hospital
8. Regional Health (PDF)
9. St. Joseph Mercy Health System, Sepsis Screening Tool (PDF)
10. Stony Brook Medical Center, Pediatric Sepsis Screening Tool (PDF)
11. University of Kansas Hospital
12. UTMB Sepsis Screening Tool (PDF)

1. Cookeville Regional Medical Center, Severe Sepsis Clinical Pathway (PDF)
2. Cooper University Hospital, Severe Sepsis Protocol Checklist (PDF)
3. Heart of England NHS Trust Critical Care Unit Treatment Pathways (PDF)
4. Novato Community Hospital - Severe Sepsis Critical Actions Checklist (PDF)
5. Novato Community Hospital - Severe Sepsis Therapy Orders Checklist (PDF)
6. NTUH Checklist for Severe Sepsis and Septic Shock (PDF)
7. Pomona Valley Hospital - Sever Sepsis Clinical Pathway (PDF)
8. Presbyterian Intercommunity Hospital, Severe Sepsis Checklist (PDF)
9. St. Joseph Mercy Health System, Clinical Pathway Form (PDF)
10. UCLH Emergency Department Sepsis Algorithm and Patient Record (PDF)

1. Cookeville Regional Medical Center (PDF)
2. Heart of England NHS Trust Critical Care Unit Flowchart
3. KGH ICU Multidisciplinary Checklist for the Management of Sepsis Treatmen (PDF)t
4. Loma Linda University Medical Center- The STOP Sepsis Bundle Toolkit (PDF)
5. Pomona Valley Hospital - Flowchart (PDF)
6. Presbyterian Intercommunity Hospital, Sepsis Flowchart (PDF)
7. Santa Barbara Cottage Hospital, Slay Sepsis Resuscitation Protocol (PDF)
8. St. Joseph Mercy Health System, Severe sepsis resuscitation alogrithm (PDF)

1. Sawyer, 2011, Computerised Sepsis Alert in Nonintensive Care Unit Patients (PDF)
2. McKinley, 2011, Computerized Decision Support - Methodist Hospital (PDF)
3. Vanderbilt Computer Assisted Decision Support (PDF)

Early Goal Directed Therapy of Severe Sepsis and Septic Shock. Emanual Rivers, 2001.

The ground breaking study showing a mortality advantage of a flow sheet algorithm for a 6-hr resuscitation bundle that uses target levels of mean arterial pressure (MAP), central venous pressure (CVP), urine output and central venous oxygen saturation (ScvO2). Implemented in the Emergency Department this study provided much of the rationale for the Surviving Sepsis Campaign guidelines.

Lactate Clearance vs. Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy A Randomized Clinical Trial. Jones 2010.

Elevated serum lactate is an important marker of the adequacy of tissue perfusion and is associated with increased mortality. Lactate > 4 mMol is representative of organ dysfunction and when coupled with SIRS and suspected source of infection a patient is defined as having severe sepsis. A goal of resuscitation is to reduce lactate to <2 mMol or decrease lactate ‘clearance’ more than 10% per hour. The use of 10% lactate clearance may be as effective as using ScvO2 > 70% as target for the resuscitation bundle.

Sepsis, Severe Sepsis and Septic Shock: Current Evidence For Emergency Department Management. Booker, 2011.

Comprehensive review of the evidence based for sepsis identification and treatment in the Emergency Department.

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Dellinger, 2008.

The complete and official evidence base and guidelines for the Society of Critical Care Medicine’s Surviving Sepsis Campaign. New guidelines are expected to be published summer 2012.