Ricardo Rajsbaum is currently an Associate Professor in the Department of Medicine and the director of the Center for Virus-Host Innate Immunity (CVHII) at Rutgers New Jersey Medical School. Dr. Rajsbaum performed his PhD in the laboratory of Anne O’Garra
at the MRC-NIMR, London, UK, and completed his postdoctoral training at Mount Sinai School of Medicine, New York, with Dr. Adolfo Garcia-Sastre. Dr. Rajsbaum first established his independent research program in 2014 at UTMB, studying regulation of
cytokine expression in immune cells, Pattern Recognition Receptor (PRR) signaling, regulation and function of type-I IFNs, and virus–host interactions, with a specific focus on the role of the ubiquitin system during different virus infections.
The lab moved to Rutgers in 2022 to develop the CVHII and expand Virology at Rutgers. Dr Rajsbaum’s lab has developed novel systems to study the function of the TRIM E3-ubiquitin ligase family and the process of ubiquitination in vitro and in
vivo, in the context of different viruses. Current research includes elucidating the mechanisms by which highly pathogenic viruses antagonize the immune response and hijack the ubiquitin system for replication (Ebola and Nipah; Bharaj et al., PLoS
Path, 2016; Bharaj et al., J. Virol 2017; van Tol et al., PLoS Path, 2022), the role of the ubiquitin system in promoting flavivirus replication (Giraldo et al., Nature 2020), the role of unanchored polyubiquitin chains in regulation of innate immune
signaling (Rajsbaum et al., Immunity, 2014; Hage et al., Cell Reports, 2022), innate immune antagonism by SARS-CoV-2 (Xia et al., 2020. Cell Rep; Cao et al., 2021. Cell Mol Immunol; Lokugamage et al., 2020. J Virol), and the role of post-translational
modifications in the dysregulation of the immune response during Ebola virus infection (this P01 project).
Phone: (973) 972-3557
Links: Center for Virus-Host-Innate Immunity
Center for Immunity and Inflammation