Ricardo Rajsbaum, PhDAssociate Professor, Department of Microbiology & Immunology, University of Texas Medical Branch – Galveston, Texas, USA

Ricardo Rajsbaum is currently an Associate Professor in the Department of Microbiology & Immunology at The University of Texas Medical Branch (UTMB). Dr. Rajsbaum performed his PhD in the laboratory of Anne O’Garra at the MRC-NIMR, London, UK, and completed his postdoctoral training at Mount Sinai School of Medicine, New York, with Dr Adolfo Garcia-Sastre. Dr. Rajsbaum's lab at UTMB studies regulation of cytokine expression in immune cells, Pattern Recognition Receptor (PRR) signaling, regulation and function of type-I IFNs, and virus–host interactions, with a specific focus on the role of the ubiquitin system during different virus infections. The lab has developed novel systems to study the function of the TRIM E3-ubiquitin ligase family and the process of ubiquitination in vitro and in vivo, in the context of different viruses. Current research includes elucidating the mechanisms by which highly pathogenic viruses antagonize the immune response and hijack the ubiquitin system for replication (Ebola and Nipah; Bharaj et al., PLoS Path, 2016; Bharaj et al., J. Virol 2017), the role of the ubiquitin system in promoting flavivirus replication (Giraldo et al., Nature 2020), the role of unanchored polyubiquitin chains in regulation of innate immune signaling (Rajsbaum et al., Immunity, 2014), innate immune antagonism by SARS-CoV-2 (Xia et al., 2020. Cell Rep; Cao et al., 2021. Cell Mol Immunol; Lokugamage et al., 2020. J Virol), and the role of post-translational modifications in the dysregulation of the immune response during Ebola virus infection (this P01 project)..

Email: rirajsba@utmb.edu
Phone: (409) 772-4917
Link: https://microbiology.utmb.edu/faculty/ricardo-rajsbaum-phd