Research Project 1 (RP1): Role of Epigenetic and Transcriptional Mechanisms in the Pathogenesis of Ebola Virus Disease

Project Lead: Alexander Bukreyev, PhD (University of Texas Medical Branch)
Co-Investigator: Stuart C. Sealfon, MD (Icahn School of Medicine at Mt. Sinai)

RP1

This project will result in the characterization of epigenetic and transcriptional responses to EBOV; to date no epigenetic response to any BSL-4 level virus has been characterized. The study will also result in the development of approaches to treat EBOV disease by targeting host transcriptional and epigenetic functions.

Alexander Bukreyev

The Program Proposal is aimed at identification of epigenetic and post-transcriptional mechanisms leading to dysregulated immune response to Ebola virus.

Bukreyev Lab

Website: Bukreyev Lab website
Lab Phone: (409) 772-2831

Stuart Sealfon

Dr. Sealfon’s research involves data intensive, high-throughput experimentation to generate high dimensional datasets of molecular responses and relationships and single cell studies in conjunction with top-down computational analysis and algorithm development and bottom-up stochastic and deterministic mathematical modeling to interpret these datasets. Dr. Sealfon will support the bioinformatics analysis needed for Research Project 1.

Sealfon Lab