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Featured Recent Publications by UTMB Environmental Toxicology Trainees

Crofton EJ, Nenov MN, Zhang Y, Tapia CM, Donnelly J, Koshy S, Laezza F, Green TA. Topographic transcriptomics of the nucleus accumbens shell: Identification and validation of fatty acid binding protein 5 as target for cocaine addiction. Neuropharmacology. 2021 Feb 1;183:108398. doi: 10.1016/j.neuropharm.2020.108398. Epub 2020 Nov 9. PMID: 33181146; PMCID: PMC7755097.

Lozovyy V, Richardson L, Saade G, Menon R. Progesterone Receptor Membrane Components: Key Regulators of Fetal Membrane Integrity1. Biol Reprod. 2020 Oct 13:ioaa192. doi: 10.1093/biolre/ioaa192. Epub ahead of print. PMID: 33048113.

Tapia CM, Folorunso O, Singh AK, McDonough K, Laezza F. Effects of Deltamethrin Acute Exposure on Nav1.6 Channels and Medium Spiny Neurons of the Nucleus Accumbens. Toxicology. 2020 Jul;440:152488. doi: 10.1016/j.tox.2020.152488. Epub 2020 May 6. PMID: 32387285; PMCID: PMC8082574.

Omere C, Richardson L, Saade GR, Bonney EA, Kechichian T, Menon R. Interleukin (IL)-6: A Friend or Foe of Pregnancy and Parturition? Evidence From Functional Studies in Fetal Membrane Cells. Front Physiol. 2020 Jul 24;11:891. doi: 10.3389/fphys.2020.00891. PMID: 32848846; PMCID: PMC7397758.

Lauren Richardson, PhD; E. Radnaa; R. Urrabaz-Garza; N. Lavu; R. Menon. Stretch, Scratch, and Stress: Suppressors and Supporters of Senescence in Human Fetal Membranes. Placenta, 2020, PDMI: 32750642 

N. Lavu; Lauren Richardson; E. Bonney; R. Menon. Glycogen synthase kinase (GSK) 3 in pregnancy and parturition: a systematic review of literature. J Matern Fetal Neonatal Med, Jun 2020, PMID: 30278798  

Wadsworth PA, Singh AK, Nguyen N, Dvorak NM, Tapia CM, Russell WK, Stephan C, Laezza F. JAK2 regulates Nav1.6 channel function via FGF14Y158 phosphorylation. Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118786. doi: 10.1016/j.bbamcr.2020.118786. Epub 2020 Jun 26. PMID: 32599005.

Tapia CM, Folorunso O, Singh AK, McDonough K, Laezza F. Effects of Deltamethrin Acute Exposure on Nav1.6 Channels and Medium Spiny Neurons of the Nucleus Accumbens. Toxicology. 2020 Jul;440:152488. doi:10.1016/j.tox.2020.152488. Epub 2020 May 6. PMID: 32387285.

Singh AK, Wadsworth PA, Tapia CM, Aceto G, Ali SR, Chen H, D'Ascenzo M, Zhou J, Laezza F. Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability. Physiol Rep. 2020 Jul;8(14):e14505. doi: 10.14814/phy2.14505. PMID: 32671946; PMCID: PM 7363588.

Lauren Richardson, PhD; R. Taylor; R. Menon. Reversible EMT and MET mediate amnion remodeling during pregnancy and labor. Science Signaling, February 2020, PDMI: 32047115 

Lauren Richardson, PhD; P. Menon; R. Menon. The effects of extracellular matrix rigidity on 3-dimensional cultures of amnion membrane cells. Placenta, January, 2020, PDMI: 32056556    

Corsello T, Kudlicki AS, Garofalo RP, Casola A. Cigarette smoke condensate changes RNA content of extracellular-vesicles released from small airway epithelial cells. Cells. 3 2019 Dec 17;8(12). doi: 10.3390/cells8121652. PubMed PMID: 31861112; PubMed Central PMCID: PMC6953119.

N. Lavu, MD; Lauren Richardson, PhD; E. Radnaa, PhD; T. Kechichian, MS; R. Urrabaz-Garza, BS; S. Sheller-Miller, PhD; E. Bonney, MD; R. Menon, PhD. Oxidative Stress Induced Downregulation of Glycogen Synthase kinase 3β (GSK3β) in Fetal Membranes Promotes Cellular Senescence, Biology of Reproduction, November, 2019, PMID: 31292604  

Lauren Richardson, Sehoon Jeong, Sungjin Kim, Arum Han, Ramkumar Menon. Amnion Membrane Organ-On-Chip: An innovative approach to study cellular interactions, FASEB, 2019, PMID: 31039044  

L. Martin, Lauren Richardson, S. Sheller-Miller, R. Menon. Dexamethasone induces amnion cell senescence through p38 MAPK independent but telomere - p21 dependent pathway, Biology of Reproduction, Jun 2019, PMID: 30927408  

Girer, N.G.; Carter, D.; Bhattarai, N.; Mustafa, M.; Denner, L.; Porter, C.; Elferink, C.J. Inducible Loss of the Aryl Hydrocarbon Receptor Activates Perigonadal White Fat Respiration and Brown Fat Thermogenesis via Fibroblast Growth Factor 21. Int. J. Mol. Sci. 2019, 20, 950. 

Lauren Richardson, J. Gnecco, T. Ding, K. Osteen, D. Aronoff, R. Menon. Fetal membrane organ on chip: An innovative approach to study feto-maternal cellular interactions. Reproductive Sciences, February, 2019, PMID: 30791822  

Tian B, Liu Z, Litvinov J, Maroto R, Jamaluddin M, Rytting E, Patrikeev I, Ochoa L, Vargas G, Motamedi M, Ameredes BT, Zhou J, Brasier AR. Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling.  Am J Respir Cell Mol Biol. 2019 Jan;60(1):68-83. doi: 10.1165/rcmb.2017-0445OC. PMID: 30153047 

R. Menon, Lauren Richardson, M. Lappas. Fetal Membrane Architecture, Aging and Inflammation in Pregnancy and Parturition. Placenta, Nov. 2018, PMID: 30454905  

Lauren Richardson; S. Sheller-Miller; L. Martin; J. Jin; R. Menon. Systematic review of p38 mitogen-activated kinase and its functional role in reproductive tissues. American Journal of Reproductive Immunology, August, 2018, PMID: 30178469  

Lauren Richardson; Christopher Dixon; Leopoldo Aguilera-Aguirre; R. Menon. Oxidative Stress-Induced TGF-beta/TAB1-mediated p38 MAPK Activation in Human Amnion Epithelial Cells. Biology of Reproduction, June, 2018, PMID:29893818  

Lauren Richardson and R. Menon. Proliferative, Migratory, and Transition Properties Reveals Metastate of Human Amnion Cells. American Journal of Pathology, June, 2018, 188(9):2004-2015, PMID: 29981743  

J. Jin; Lauren Richardson; S. Sheller-Miller; N. Zhong; R. Menon. Oxidative stress induces p38 MAPK-dependent senescence in the feto-maternal interface cells. Placenta, May, 2018, 67:15-23, PMID: 29941169  

J. Polettini; Lauren Richardson; R. Menon. Oxidative stress induces senescence and sterile inflammation in murine amniotic cavity. Placenta, January, 2018, 63:26-31, PMID: 29486853  

Ochoa LF, Kholodnykh A, Tian B, Pal R, Villarreal P, Freiberg A, Brasier AR, Motamedi M, Vargas G. Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy Aided by Tissue Optical Clearing. Scientific Reports, Sci Rep. 2018 Sep 6;8(1):13348. PMID: 30190498 

Shah M, Bourner L, Ali S, Al-Enazy S, Youssef MM, Fisler M, Rytting E. HPLC Method Development for Quantification of Doxorubicin in Cell Culture and Placental Perfusion Media Separations. 2018 Mar;5(1):9. doi: 10.3390/separations5010009. Epub 2018 Jan 24. PMID: 29984222; PMCID: PMC6035002.

Shah M, Bourner L, Ali S, Al-Enazy S, Rytting E. Cytotoxicity of Endocytosis and Efflux Inhibitors in the BeWo Cell Line. J Pharm Res Int. 2017;17(5):JPRI.34606. doi: 10.9734/JPRI/2017/34606. Epub 2017 Jul 1. PMID: 29214230; PMCID: PMC5714556.

James TF, Nenov MN, Tapia CM, Lecchi M, Koshy S, Green TA, Laezza F. Consequences of acute Nav1.1 exposure to deltamethrin. Neurotoxicology. 2017 May;60:150-160. doi: 10.1016/j.neuro.2016.12.005. Epub 2016 Dec 19. PMID: 28007400; PMCID: PMC5447465.

Patel JP, Sowers ML, Herring JL, Theruvathu JA, Emmett MR, Hawkins BE, Zhang K, DeWitt DS, Prough DS, Sowers LC. Measurement of Postreplicative DNA Metabolism and Damage in the Rodent Brain. Chem Res Toxicol. 2015 Dec 21;28(12):2352-63. doi: 10.1021/acs.chemrestox.5b00359. Epub 2015 Nov 24. PMID: 26447562.

LY Koong and CS Watson. Xenoestrogen-induced signaling leading to cell viability changes on early- vs. late-stage prostate cancer cells, Endocrine Disruptors, 3:1 2015  e995003, DOI:10.4161/23273747.2014.99500

Reno AL, Brooks EB, Ameredes BT. Mechanisms of heightened airway sensitivity and responses to SO2 in asthmatics. Environmental Health Insights. Suppl. 1:13-25, 2015. doi: 10.4137/EHI.S15671 PMCID-PMC4384764. Pubmed link:

Daniel P. Jackson, Hui Li, Kristen A. Mitchell, Aditya D. Joshi, and Cornelis J. Elferink. Ah Receptor Mediated Suppression of Liver Regeneration through NC-XRE-Driven p21Cip1 Expression. Mol Pharmacol mol.113.089730; published ahead of print January 15, 2014, doi:10.1124/mol.113.089730;  available as Fast Forward Article at:

LY Koong, CS Watson. Direct estradiol and diethylstilbestrol actions on early- versus late-stage prostate cancer cells. The Prostate. 2014. doi: 10.1002/pros.22875. PubMed PMID: 25213831.

Viñas R, Watson CS. Mixtures of xenoestrogens disrupt estradiol-induced non-genomic signaling and downstream functions in pituitary cells. Environ Health. 2013 Mar 26;12(1):26. [Epub ahead of print] PMID: 23530988

Viñas R, Watson CS. Bisphenol S disrupts estradiol-induced nongenomic signaling in a rat pituitary cell line: effects on cell functions. Environ Health Perspect. 2013 Mar;121(3):352-8. doi: 10.1289/ehp.1205826. Epub 2012 Dec 13. PMID: 23458715

Harper TA Jr, Joshi AD, Elferink CJ. Identification of stanniocalcin 2 as a novel aryl hydrocarbon receptor target gene. J Pharmacol Exp Ther. 2013 Mar;344(3):579-88. doi: 10.1124/jpet.112.201111. Epub 2012 Dec 26.

Ruiz J, Ameredes BT. The cellular effects of carbon monoxide in the airway. Curr Mol Med. 2013 Jan;13(1):94-108. Review. PMID: 22834843

Bjorklund NL, Reese LC, Sadagoparamanujam VM, Ghirardi V, Woltjer RL, Taglialatela G. Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer's disease neuropathology. Mol Neurodegener. 2012 May 28;7:23. doi: 10.1186/1750-1326-7-23. PMID:22640423

Hochman DJ, Collaco CR, Brooks EG. Acrolein induction of oxidative stress and degranulation in mast cells. Environ Toxicol. 2012 Oct 10. doi: 10.1002/tox.21818. [Epub ahead of print] PMID:23047665

Bjorklund NL, Sadagoparamanujam VM, Taglialatela G. Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients. J Neurosci Methods. 2012 Jan 15;203(1):146-51. doi: 10.1016/j.jneumeth.2011.09.008. Epub 2011 Sep 16. PMID:21945000

Reese LC, Taglialatela G. A role for calcineurin in Alzheimer's disease. Curr Neuropharmacol. 2011 Dec;9(4):685-92. doi: 10.2174/157015911798376316. PMID:22654726

Rondelli CM, El-Zein RA, Wickliffe JK, Etzel CJ, Abdel-Rahman SZ. A comprehensive haplotype analysis of the XPC genomic sequence reveals a cluster of genetic variants associated with sensitivity to tobacco-smoke mutagens. Toxicol Sci. 2010 May;115(1):41-50. doi: 10.1093/toxsci/kfq027. Epub 2010 Jan 27. PMID:20106949

Herring JL, Rogstad DK, Sowers LC. Enzymatic methylation of DNA in cultured human cells studied by stable isotope incorporation and mass spectrometry. Chem Res Toxicol. 2009 Jun;22(6):1060-8. doi: 10.1021/tx900027w. PMID: 19449810