Germ-free Mouse Facility


The UTMB germ-free mouse facility (GFF) provides service to entire UTMB community to breed mice in germ-free conditions and colonize them with selected commensal/probiotic/pathogenic bacteria (gnotobiotic animals) or reconstitute germ-free mouse with human fecal microbiota (humanized gnotobiotic animals). Housed on the ground floor of the Medical Research Building (MRB), the GFF is supported by the IHII, the Office for Research, the ARC, a University of Texas System STARs award, and the John Sealy Memorial Endowment. The equipment in the facility includes three double-tier flexible film isolator tables, which accommodate six bubbles/~90 standard mouse cages, a 50-cage breeder isolator unit, five sterilizing cylinders, three sterilizing table units and three atomizer units; an ISOcage bioexclusion system (30 cages); two Class II Biological Safety Cabinets; two dedicated autoclaves.