UTMB develops an oral vaccine against Salmonella

Jan 19, 2017, 17:32 PM by Donna Ramirez
Salmonella
UTMB researchers have developed a vaccine against salmonella poisoning designed to be taken by mouth. The findings are detailed in an article published in Frontiers in Cellular and Infection Microbiology.

In earlier studies, the UTMB researchers developed potential vaccines from three genetically mutated versions of the Salmonella typhimurium bacterium, that were shown to protect mice against a lethal dose of salmonella. In these studies, the vaccines were given as an injection.

However, oral vaccination is the simplest and least invasive way to protect people against salmonella infection.Taking this vaccine by mouth also has the advantage of using the same pathway that salmonella uses to wreak havoc on the digestive system.

“In the current study, we analyzed the immune responses of mice that received the vaccination by mouth as well as how they responded to a lethal dose of salmonella,” said Ashok Chopra, PhD, UTMB professor of microbiology and immunology. “We found that the orally administered vaccines produced strong immunity against salmonella, showing their potential for future use in people.”

There is no vaccine currently available for salmonella poisoning. Antibiotics are the first choice in treating salmonella infections, but the fact that some strains of salmonella are quickly developing antibiotic resistance is a serious concern. Another dangerous aspect of salmonella is that it can be used as a bioweapon—this happened in Oregon when a religious cult intentionally contaminated restaurant salad bars and sickened 1,000 people.

Salmonella is responsible for one of the most common food-borne illnesses in the world. In the U.S. alone, the Centers for Disease Control and Prevention estimates there are about 1.4 million cases with 15,000 hospitalizations and 400 deaths each year. It is thought that for every reported case, there are approximately 39 undiagnosed infections. Overall, the number of salmonella cases in the U.S. has not changed since1996.

Salmonella infection in people with compromised immune systems and children under the age of 3 are at increased risk of invasive non-typhoidal salmonellosis, which causes systemic infection. There are about one million cases globally per year, with a 25-percent fatality rate.

Other authors include UTMB’s Tatiana Erova; Michelle Kirtley; Eric Fitts; Duraisamy Ponnusamy, PhD; Jourdan Andersson; Yingzi Cong, PhD; Bethany Tiner, PhD; and Dr. Jian Sha as well as Wallace Baze, DVM, PhD, from the University of Texas MD Anderson Cancer Center. The study was supported by UTMB and the National Institutes of Health.