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OPRU Protocols

The following is a list of research protocols (clinical, basic/translational, and pilot studies) conducted by the former OPRU Network between 2004 and 2014.
  • Pravastatin for the Prevention of Preeclampsia in High-Risk Women: A Phase I Pilot Study
  • Glyburide and Metformin for Gestational Diabetes Mellitus: A Phase I-II Randomized Trial
  • Determining the Pharmacodynamic Impact of Vaginal and 1M Progestins on the Cervix
  • Pharmacokinetics of Understudied Drugs Used During Pregnancy (Opportunistic)
  • Pharmacokinetics and Pharmacodynamics of Glyburide in Gestational Diabetics and Type 2 Diabetics (Glyburide)
  • A Study of the Pharmacology of 17-Hydrozyprogesterone Caproate in Pregnancy (Caproate)
  • Levothyroxine Pharmacokinetics Based on State-of-the-Art Analytic Methods (Levothyroxine)
  • A Double-Blind Multicenter Randomized Placebo Controlled Trial of the Efficacy of Diclectin® for Nausea and Vomiting of Pregnancy
  • Clonidine Hemodynamic Effects during Pregnancy
  • Effects of Pregnancy on Metformin Pharmacokinetics
  • Human Placental Transfer of Metformin and Rosiglitazone
  • Human Placental Transfer of Glyburide
  • Placental Biotransformation of Glyburide during Pregnancy: Implications for Identification of the Enzymes and Metabolites
  • Placental Transfer and Biotransformation of 17-Hydroxyprogestrone Caproate
  • Bcrp1/ABCG2 and Fetal Distribution of Glyburide
  • Effects of Pregnancy on Clonidine Pharmacokinetics
  • Dacarbazine and the Effects of Pregnancy on CYP1A2
  • Cyclosporine and Placental P-glycoprotein Activity
  • 17-OHPC Basic Science Studies
  • Gestational-Age-Dependent Changes in Placental P-glycoprotein Activity in the non-human primate, Macaca nemestrina
  • Pharmacokinetics of Oseltamivir among Pregnant and Nonpregnant Women
  • Impact of Glucocorticoid Polymorphisms on Markers of Neonatal Respiratory Disease after Antenatal Betamethasone Administration
  • Duration of Cisplatin Excretion in Breast Milk
  • Tacrolimus Concentrations during Pregnancy and Postpartum
  • Transplacental Transfer of Vancomycin and Televancin